YIDC_PORGI
ID YIDC_PORGI Reviewed; 627 AA.
AC P60036;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=PG_0526;
OS Porphyromonas gingivalis (strain ATCC BAA-308 / W83).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas.
OX NCBI_TaxID=242619;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-308 / W83;
RX PubMed=12949112; DOI=10.1128/jb.185.18.5591-5601.2003;
RA Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E.,
RA Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L.,
RA Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J.,
RA Granger D., Tettelin H., Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E.,
RA Fraser C.M.;
RT "Complete genome sequence of the oral pathogenic bacterium Porphyromonas
RT gingivalis strain W83.";
RL J. Bacteriol. 185:5591-5601(2003).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR EMBL; AE015924; AAQ65720.1; -; Genomic_DNA.
DR RefSeq; WP_005875081.1; NC_002950.2.
DR AlphaFoldDB; P60036; -.
DR SMR; P60036; -.
DR STRING; 242619.PG_0526; -.
DR EnsemblBacteria; AAQ65720; AAQ65720; PG_0526.
DR KEGG; pgi:PG_0526; -.
DR PATRIC; fig|242619.8.peg.481; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_016535_2_0_10; -.
DR OMA; WGIFGWI; -.
DR OrthoDB; 524437at2; -.
DR BioCyc; PGIN242619:G1G02-485-MON; -.
DR Proteomes; UP000000588; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..627
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124736"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 502..522
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 534..554
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 558..578
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ SEQUENCE 627 AA; 72008 MW; 5004AD4D7CF035F7 CRC64;
MDKNTVIGLV LIGLVIFGFS WLNRPDPQEI EAQRKAAIEA ARQDSIAKAE AELLAARTQG
ATPDSIKQAA GYNQYGLLAA ATAGAEEQVE LANGKIALKL STKGGAIREV LLRDYKTHDG
KPLYLFREGE SDFNLPLRTV DNRLVDTRDL YFSPISRTDS SVVMRLAVDS ASYLDLAYVL
LPDDYRLRMT VSGQNLQSLF PANMTMQDLE WSQRIRRQEK SWKFENQYTS IYYKYSGDEV
DRLSDSKQED KKTLEEPLHW VSFKDKYFAS VLVCDSYFEN NKLAQKTAAA GSDYLKNCTM
SATFPLDVRS GTKARFTFFF GPLKYNMLRA YDKGMKAEDN LDLDHLVYLG ASIFRWINRY
MIIPASTFLQ QYFSNWGLII LLLTLGIKLL ISPLAYKGYL SSAKMRLLRP QVQEINAKYP
GKDQESMMKR QSATMNLYRA AGAGPMSGCL PMLLQFPFLI AMYMYFPTTI DIRQQSFLWA
EDLSSYDAVF SWTADIPLLS QFYGNHVSLF CLLMSISNIL YIRYTMNQSD TGQEGMAMLK
WMPYITTVMF LFFFNQNASG LCYYYFLSSI ITVIQYMSSR FIINEEKLMA KLEANKTKPR
KKSKWMARLE EAQRQQEAMR RQQQKRK
