ID   YIDC_PROMA              Reviewed;         382 AA.
AC   Q7VB00;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=Pro_1302;
OS   Prochlorococcus marinus (strain SARG / CCMP1375 / SS120).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167539;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SARG / CCMP1375 / SS120;
RX   PubMed=12917486; DOI=10.1073/pnas.1733211100;
RA   Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M.,
RA   Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S.,
RA   Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J.,
RA   Tandeau de Marsac N., Weissenbach J., Wincker P., Wolf Y.I., Hess W.R.;
RT   "Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a
RT   nearly minimal oxyphototrophic genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Probably also aids protein insertion, folding and/or assembly
CC       of membrane complexes destined for the thylakoid. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE017126; AAQ00346.1; -; Genomic_DNA.
DR   RefSeq; NP_875693.1; NC_005042.1.
DR   RefSeq; WP_011125453.1; NC_005042.1.
DR   AlphaFoldDB; Q7VB00; -.
DR   STRING; 167539.Pro_1302; -.
DR   EnsemblBacteria; AAQ00346; AAQ00346; Pro_1302.
DR   GeneID; 54200637; -.
DR   KEGG; pma:Pro_1302; -.
DR   PATRIC; fig|167539.5.peg.1367; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_038573_0_0_3; -.
DR   OMA; KITPVMI; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000001420; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..382
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124737"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          356..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   382 AA;  41426 MW;  12101B3452EB9345 CRC64;
     MIGFLSDNLL IPILDFFYGL FHSYGIAIVA LTIVIRIALF PLSAGSIRSA RRMKIAQPVM
     QKRQAEIKSR YANDPKKQQD ELGKLMGEFG SPLAGCLPLL VQMPILFALF ATLRGSPFAD
     VPYLVNLKIL PPEQIAAVEP KPFKSPRHSI FISDKDHFPV IASLPGGTKI AAGDSVNIKL
     ETLSGEKYSN VLGKFENGSK FSPTWKLTKG ADLASVSADG TVTAKYPGDA TVEGKIPGLA
     AKSGFLFIKA LGQVGFYVDG AINWDIAILV AGFGLTLVIS QVLSGQGMPP NPQQATAQKI
     TPIMITGMFL FFPLPAGVLL YMVIANMFQA FQTFLLNKEA LPENLQKILD DQIKNQGKKE
     LATSPAIDSE RLPFEPKSNK QN