ID   YIDC_PROMI              Reviewed;         237 AA.
AC   P22833;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
DE   Flags: Fragment;
GN   Name=yidC;
OS   Proteus mirabilis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=584;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LM1509;
RX   PubMed=2172087; DOI=10.1016/0378-1119(90)90131-a;
RA   Skovgaard O.;
RT   "Nucleotide sequence of a Proteus mirabilis DNA fragment homologous to the
RT   60K-rnpA-rpmH-dnaA-dnaN-recF-gyrB region of Escherichia coli.";
RL   Gene 93:27-34(1990).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; M58352; AAA83954.1; -; Genomic_DNA.
DR   PIR; JQ0729; JQ0729.
DR   AlphaFoldDB; P22833; -.
DR   SMR; P22833; -.
DR   STRING; 584.AOUC001_19010; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..>237
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124738"
FT   TRANSMEM        7..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          34..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         237
SQ   SEQUENCE   237 AA;  26664 MW;  07FCC405B9DB3F36 CRC64;
     MDSQRNLLFI ALLFVSFLIW QQWEGDKVSQ NTTTTTQVSQ QADMPSSDSL AVTGNSNEQA
     KLITVKTDVL DLRINTQGGT IDEADLLAYP AELNSKTPFR LLETTPQFLY QAQSGLIGPD
     GPDQKSRPVY SATQQEFILG ENQDELRVPM TFVNEEGVKF VKTFILKKGQ YDIGIEYKVE
     NPTDKTLTMN FYGQLKQSVK LPEHRDTGSS NFALHTYRGA AYSSDETNYK KYSFGDI