ID   YIDC_PROMM              Reviewed;         378 AA.
AC   Q7V610;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=PMT_1371;
OS   Prochlorococcus marinus (strain MIT 9313).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=74547;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9313;
RX   PubMed=12917642; DOI=10.1038/nature01947;
RA   Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A.,
RA   Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L.,
RA   Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C.,
RA   Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R.,
RA   Chisholm S.W.;
RT   "Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche
RT   differentiation.";
RL   Nature 424:1042-1047(2003).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Probably also aids protein insertion, folding and/or assembly
CC       of membrane complexes destined for the thylakoid. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BX548175; CAE21546.1; -; Genomic_DNA.
DR   RefSeq; WP_011130739.1; NC_005071.1.
DR   AlphaFoldDB; Q7V610; -.
DR   STRING; 74547.PMT_1371; -.
DR   EnsemblBacteria; CAE21546; CAE21546; PMT_1371.
DR   KEGG; pmt:PMT_1371; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_038573_0_0_3; -.
DR   OMA; KITPVMI; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000001423; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..378
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124739"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   378 AA;  40735 MW;  64D90841A755EBD1 CRC64;
     MIGYISDNIL LPILDFFYGL VPSYGLAIVA LTVVIRLALF PLSAGSIRSA RRMRIAQPAM
     KKRQDEIKSR YAKDPQKQQE ELGKVMKEFG NPLSGCLPLL VQMPILFALF ATLRGSPFAD
     VPYLVNLKVL PSDQIAAIEP KPFTSSKHSI FISETKHFPV IASLPSGTKL GVGDKAQIKL
     QTLTGESFTS RLSGVEGGTK FTPTWSVTKG DDLVKVSADG TVQALAEGDA TVQGKIPGLA
     AQSGFLFIKA LGQVGFYVDG EINWDIAILV GGFGLTLLVS QILSGRGLPA NPQQSTANKI
     TPVMITGMFL FFPLPAGVLL YMVIANIFQA GQTFLLSREA LPENLQKILN DQLSKPALAT
     EAIGGSDRLP FEPKKRSK