ID   YIDC_PROMP              Reviewed;         379 AA.
AC   Q7V0R8;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=PMM1186;
OS   Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 /
OS   MED4).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP1986 / NIES-2087 / MED4;
RX   PubMed=12917642; DOI=10.1038/nature01947;
RA   Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A.,
RA   Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L.,
RA   Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C.,
RA   Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R.,
RA   Chisholm S.W.;
RT   "Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche
RT   differentiation.";
RL   Nature 424:1042-1047(2003).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Probably also aids protein insertion, folding and/or assembly
CC       of membrane complexes destined for the thylakoid. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BX548174; CAE19645.1; -; Genomic_DNA.
DR   RefSeq; WP_011132820.1; NC_005072.1.
DR   AlphaFoldDB; Q7V0R8; -.
DR   STRING; 59919.PMM1186; -.
DR   EnsemblBacteria; CAE19645; CAE19645; PMM1186.
DR   KEGG; pmm:PMM1186; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_038573_0_0_3; -.
DR   OMA; KITPVMI; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000001026; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..379
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124740"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   379 AA;  41262 MW;  F5E9029078B36AF1 CRC64;
     MIGFISEKLL IPILDFFYGL VPSYGLAIVA LTVVIRIALF PLSAGSIRSA RRMKIAQPVM
     QKRQAEIKSK FSSDPKKQQE ELGKLMNEFG SPLAGCLPLI VQMPVLFALF ATLRGSPFAD
     VPYNINLKVL PQDQIAAIDP KPYKSPRHSI FVTEKSHFPV IATLPNGTKL GSEESVKINL
     QTTNGNNYSE VLSNYDNGSR FLPTWTVSKG SENIKVSQDG LVTAIKPGDA TIEAKIPGLA
     AKSGFLFIKA LGQVGFYVDG SINWDIATLV GAFGLTLLLS QVLSSQGMPS NAQQSTANKI
     TPVMITGMFL FFPLPAGVLL YMVVANIFQA FQTFLLNKEA LPANLQKILD DQLTGKNKVI
     PSTANISDKR LPFEPNNKK