YIDC_PSEAE
ID YIDC_PSEAE Reviewed; 578 AA.
AC Q9HT06;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=PA5568;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR EMBL; AE004091; AAG08953.1; -; Genomic_DNA.
DR PIR; G82950; G82950.
DR RefSeq; NP_254255.1; NC_002516.2.
DR RefSeq; WP_003114648.1; NZ_QZGE01000012.1.
DR AlphaFoldDB; Q9HT06; -.
DR SMR; Q9HT06; -.
DR STRING; 287.DR97_2947; -.
DR PaxDb; Q9HT06; -.
DR PRIDE; Q9HT06; -.
DR EnsemblBacteria; AAG08953; AAG08953; PA5568.
DR GeneID; 878127; -.
DR KEGG; pae:PA5568; -.
DR PATRIC; fig|208964.12.peg.5834; -.
DR PseudoCAP; PA5568; -.
DR HOGENOM; CLU_016535_3_0_6; -.
DR InParanoid; Q9HT06; -.
DR OMA; INPVAGC; -.
DR PhylomeDB; Q9HT06; -.
DR BioCyc; PAER208964:G1FZ6-5695-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 2.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03593; yidC_nterm; 2.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..578
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124741"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 500..520
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 535..555
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT REGION 34..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 578 AA; 64075 MW; 0325CC1FFE9B6A68 CRC64;
MDIQRSILIV ALAVVSYLLV LQWNKDYGQP ELPAASASMN TTQGLPDTPS ASGTSSDVPT
AQSSAAGSEA ADKPVAVSDK LIQVKTDVLD LAIDPRGGDI VQLGLLQYPR RLDRPDVPFP
LFDNGRERTY LAQSGLTGAD GPDASSAGRP LFRSAQSSYQ LADGQNELVV DLSFSHDGVN
YIKRFTFHRG LKADCSDKEK AQKKIECINE NAYQVGVSYL IDNQSGKTWS GNLFAQLKRD
GSADPSSTTA TGVSTYLGAA VWTPDSPYKK ISTKDMDKEQ FKESVQGGWV AWLQHYFVTA
WVPTKGEQHQ VMTRKDGQGN YIVGFTGPTL SVPAGSKVET DLTLYAGPKL QKHLKELSPG
LELTVDYGFL WFIAQPIFWL LQHIHSLIGN WGWSIIALTV LIKLAFFPLS AASYRSMARM
RAVSPKMQAI KEQHGDDRQK MSQAMMELYK KEKINPLGGC LPILVQMPVF LSLYWVLLES
VEMRQAPWLG WITDLSVKDP FFILPIVMGG TMLIQQMLNP TPPDPMQAKV MKLMPIIFTF
FFLWFPAGLV LYWVVNNCLS IAQQWYITRK IEAAAKTA
