YIDC_PSEF5
ID YIDC_PSEF5 Reviewed; 566 AA.
AC Q4K395;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=PFL_6230;
OS Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=220664;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-477 / NRRL B-23932 / Pf-5;
RX PubMed=15980861; DOI=10.1038/nbt1110;
RA Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A.,
RA Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J.,
RA Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A., Rosovitz M.J.,
RA Gwinn M.L., Zhou L., Schneider D.J., Cartinhour S.W., Nelson W.C.,
RA Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A., Pierson L.S. III,
RA Thomashow L.S., Loper J.E.;
RT "Complete genome sequence of the plant commensal Pseudomonas fluorescens
RT Pf-5.";
RL Nat. Biotechnol. 23:873-878(2005).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR EMBL; CP000076; AAY95418.1; -; Genomic_DNA.
DR RefSeq; WP_011064394.1; NC_004129.6.
DR AlphaFoldDB; Q4K395; -.
DR SMR; Q4K395; -.
DR STRING; 220664.PFL_6230; -.
DR EnsemblBacteria; AAY95418; AAY95418; PFL_6230.
DR GeneID; 57479191; -.
DR KEGG; pfl:PFL_6230; -.
DR PATRIC; fig|220664.5.peg.6361; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_016535_3_0_6; -.
DR OMA; INPVAGC; -.
DR OrthoDB; 524437at2; -.
DR Proteomes; UP000008540; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..566
FT /note="Membrane protein insertase YidC"
FT /id="PRO_1000070140"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 521..541
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT REGION 38..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 62650 MW; F7D42565B7A2BF6B CRC64;
MDIKRTILIV ALAIVSYVMV LKWNQDYGQA ALPTQNVASS TTAPGLPDAP TGTSAANDDI
PRAASDTTAP AEAPVAASKD LIQIKTDVLD LAVDPQGGDI AQLRLPLYPR RQDHPEIPFQ
LFDNGNERTY LAQSGLIGSN GPDASPAGRP IYSAEKKSYQ LADGQDQLVV DLKFSKDGVN
YIKRFTLKRG LYDITVSYLI DNESAQPWTG AMFAQLKRDA SSDPSSSTAT GTATYLGAAL
WTSSEPYKKV SMKDMDKVNE DKSKAPITEN VQGGWVAWLQ HYFVTAWIPP KGENNQVLAR
KDSKGNYIIG YTGPSMTVAP GAKAETSAIL YAGPKSQAVL KELSPGLELT VDYGFLWFIA
QPIFWLLQHI HSLVGNWGWS IIFLTMLIKG IFFPLSAASY KSMARMRAVA PKLAALKEKF
GDDRQKMSQA MMELYKKEKI NPLGGCLPIL VQMPVFLSLY WVLLESVEMR QAPFMLWITD
LSIKDPFFIL PIIMGATMFI QQQLNPTPPD PMQAKVMKMM PIIFTFFFLW FPAGLVLYWV
VNNCLSIAQQ WYITRKIEAA TKKAAA
