ID   YIDC_PSEPU              Reviewed;         560 AA.
AC   P0A141; P25754;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810};
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TN2100;
RX   PubMed=1552862; DOI=10.1111/j.1365-2958.1992.tb01510.x;
RA   Ogasawara N., Yoshikawa H.;
RT   "Genes and their organization in the replication origin region of the
RT   bacterial chromosome.";
RL   Mol. Microbiol. 6:629-634(1992).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01810};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; X62540; CAA44417.1; -; Genomic_DNA.
DR   PIR; JQ1221; JQ1221.
DR   RefSeq; WP_010951425.1; NZ_SPUU01000003.1.
DR   AlphaFoldDB; P0A141; -.
DR   SMR; P0A141; -.
DR   STRING; 1240350.AMZE01000066_gene3191; -.
DR   eggNOG; COG0706; Bacteria.
DR   OMA; INPVAGC; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..560
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124743"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        468..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        515..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   REGION          42..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   560 AA;  61920 MW;  C49F917086F8E3CF CRC64;
     MDIKRTILIA ALAVVSYVMV LKWNDDYGQA ALPTQNTAAS TVAPGLPDGV PAGNNGASAD
     VPSANAESSP AELAPVALSK DLIRVKTDVL ELAIDPVGGD IVQLNLPKYP RRQDHPNIPF
     QLFDNGGERV YLAQSGLTGT DGPDARASGR PLYAAEQKSY QLADGQEQLV VDLKFSDNGV
     NYIKRFSFKR GEYDLNVSYL IDNQSGQAWN GNMFAQLKRD ASGDPSSSTA TGTATYLGAA
     LWTASEPYKK VSMKDIDKGS LKENVSGGWV AWLQHYFVTA WIPAKSDNNV VQTRKDSQGN
     YIIGYTGPVI SVPAGGKVET SALLYAGPKI QSKLKELSPG LELTVDYGFL WFIAQPIFWL
     LQHIHSLLGN WGWSIIVLTM LIKGLFFPLS AASYRSMARM RAVAPKLAAL KERFGDDRQK
     MSQAMMELYK KEKINPLGGC LPILVQMPVF LALYWVLLES VEMRQAPWIL WITDLSIKDP
     FFILPIIMGA TMFIQQRLNP TPPDPMQAKV MKMMPIIFTF FFLWFPAGLV LYWVVNNCLS
     ISQQWYITRR IEAATKKAAA