YIDC_RHOBA
ID YIDC_RHOBA Reviewed; 827 AA.
AC Q7UFZ2;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Membrane protein insertase YidC;
DE AltName: Full=Foldase YidC;
DE AltName: Full=Membrane integrase YidC;
DE AltName: Full=Membrane protein YidC;
GN Name=yidC; OrderedLocusNames=RB8240;
OS Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1).
OC Bacteria; Planctomycetes; Planctomycetia; Pirellulales; Pirellulaceae;
OC Rhodopirellula.
OX NCBI_TaxID=243090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10527 / NCIMB 13988 / SH1;
RX PubMed=12835416; DOI=10.1073/pnas.1431443100;
RA Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W.,
RA Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R.,
RA Reinhardt R.;
RT "Complete genome sequence of the marine planctomycete Pirellula sp. strain
RT 1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000305}.
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DR EMBL; BX294147; CAD78537.1; -; Genomic_DNA.
DR RefSeq; NP_868259.1; NC_005027.1.
DR AlphaFoldDB; Q7UFZ2; -.
DR SMR; Q7UFZ2; -.
DR STRING; 243090.RB8240; -.
DR PRIDE; Q7UFZ2; -.
DR EnsemblBacteria; CAD78537; CAD78537; RB8240.
DR KEGG; rba:RB8240; -.
DR PATRIC; fig|243090.15.peg.3972; -.
DR eggNOG; COG0265; Bacteria.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_342520_0_0_0; -.
DR InParanoid; Q7UFZ2; -.
DR OMA; LEGWWYS; -.
DR OrthoDB; 524437at2; -.
DR Proteomes; UP000001025; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..827
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124748"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 598..618
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 666..686
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 710..730
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..217
FT /note="PDZ"
FT REGION 58..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..827
FT /note="YidC"
FT REGION 758..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..76
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 90590 MW; 35C4DDA7B6ABAD6D CRC64;
MADSSVERRL FSFILSSMAF FLIYMSLRTM FAPPLPPEED AIAEVDGETV EPAEDLVADT
DASEPGEGEG EEANEDTDAV ERPSSPTWST LGSMDPTSGY VMLVTLNSRG GGIERIELTE
RKENGRLKYR RVDVRSGYLG YLAADPTATD LGIRVNVVGP GTPADLATAS GVQGGLKPGD
IITGFNQNNV NNLSMLREAM LETKPGESAT VTVLRNEKSI DFTTTLTEHP LDLIRLAEHG
GDDEVEGNLS RLSCLLTVGR VGRREIQSGE KTIEGMVDTG DLIWDASQDG DNVSYQLQLS
DSEMKPASGK SVGLQRTYSL KPDSYSLDMD VQIDNRAEEA QELAYRIEGA NGITLEGWWY
SNKISPNWGG SAARDIVYKT TAEGHELVSG YALLKRAKNE SEADDQTLFA PDSAPPARNL
SYIGVDAQYF TVAMLPPEGQ ESLKTFRRAA ANIIADPSAV PDNKERAVNA SFYLDSAIAD
VPPGSSLKQS LRLFAGPKQP DVMEAYGLGD CIYYGWFSFV AKPLGGLLHL FSNVGNYALA
IVLLTLCVRG LMFPLSRKAA INAQRMQELA PELKKIAEKH KDDMEARVRA QRELQQRVGF
NPMAGCAPMF LQLPIFIGLY RTLSVDIELR QAAFASWTTW ASNLAAPDMM YYWGDWMWDY
LGGRGTGWLG PYFNILPMIV VSLFLAQQKM FMPPATDEQT AMTQKMMNYM TLVMGLFFFR
VPAGLCIYFI TSSLWGIGER ILVKKTLPSK PHFDPATLQG AAAGGGTVDG KVNNSAGANG
KKSSDGKPKT MADRLRERLG TPEEEAAPLP KDRKRPPSKK PGNKKRR
