ID   CBID_METC4              Reviewed;         361 AA.
AC   Q9X7G7; B7L3N5;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Cobalt-precorrin-5B C(1)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_00787};
DE            EC=2.1.1.195 {ECO:0000255|HAMAP-Rule:MF_00787};
DE   AltName: Full=Cobalt-precorrin-6A synthase {ECO:0000255|HAMAP-Rule:MF_00787};
GN   Name=cbiD {ECO:0000255|HAMAP-Rule:MF_00787}; OrderedLocusNames=Mchl_5729;
OS   Methylorubrum extorquens (strain CM4 / NCIMB 13688) (Methylobacterium
OS   extorquens).
OG   Plasmid pMCHL01.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=440085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10200311; DOI=10.1073/pnas.96.8.4615;
RA   Vannelli T., Messmer M., Studer A., Vuilleumier S., Leisinger T.;
RT   "A corrinoid-dependent catabolic pathway for growth of a Methylobacterium
RT   strain with chloromethane.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:4615-4620(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM4 / NCIMB 13688;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Marx C., Richardson P.;
RT   "Complete sequence of plasmid1 of Methylobacterium chloromethanicum CM4.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to
CC       form cobalt-precorrin-6A. {ECO:0000255|HAMAP-Rule:MF_00787}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A +
CC         S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:26285, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:60063, ChEBI:CHEBI:60064;
CC         EC=2.1.1.195; Evidence={ECO:0000255|HAMAP-Rule:MF_00787};
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 6/10. {ECO:0000255|HAMAP-Rule:MF_00787}.
CC   -!- SIMILARITY: Belongs to the CbiD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00787}.
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DR   EMBL; AJ011317; CAB40740.1; -; Genomic_DNA.
DR   EMBL; CP001299; ACK86443.1; -; Genomic_DNA.
DR   RefSeq; WP_012606333.1; NC_011758.1.
DR   AlphaFoldDB; Q9X7G7; -.
DR   SMR; Q9X7G7; -.
DR   EnsemblBacteria; ACK86443; ACK86443; Mchl_5729.
DR   KEGG; mch:Mchl_5729; -.
DR   HOGENOM; CLU_041273_0_0_5; -.
DR   OMA; YHGKLIK; -.
DR   BioCyc; MEXT440085:MCHL_RS27865-MON; -.
DR   UniPathway; UPA00148; UER00227.
DR   Proteomes; UP000002385; Plasmid pCMU01.
DR   GO; GO:0043780; F:cobalt-precorrin-5B C1-methyltransferase activity; IEA:RHEA.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0046140; P:corrin biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2110.10; -; 1.
DR   HAMAP; MF_00787; CbiD; 1.
DR   InterPro; IPR002748; CbiD.
DR   InterPro; IPR036074; CbiD_sf.
DR   PANTHER; PTHR35863; PTHR35863; 1.
DR   Pfam; PF01888; CbiD; 1.
DR   PIRSF; PIRSF026782; CbiD; 1.
DR   SUPFAM; SSF111342; SSF111342; 1.
DR   TIGRFAMs; TIGR00312; cbiD; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis; Methyltransferase; Plasmid;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..361
FT                   /note="Cobalt-precorrin-5B C(1)-methyltransferase"
FT                   /id="PRO_0000141673"
SQ   SEQUENCE   361 AA;  37534 MW;  4913FE8B70B3B3F2 CRC64;
     MNSETGALRR GWTTGTCASA AARAAFEALL GIEPEDPVPV TLPSGARPTF ALARLDRGSG
     FVRAGIVKDA GDDPDVTHGA LVLATLRFGA PATGIVFRAG PGVGIVTKPG LPLPPGEPAI
     NAMPRRMIRT ALTEVAEANG VTCDLVVEVG IEDGERIAER TMNRRLGIIG GLSILGTTGV
     VVPYSCAAWI ASIHRGIDVA RAEGLTHLAG ATGATSEAAI RNLYGLPEQA LIDMGDFVGG
     MLKYIRGHPV ARVTIAGGFA KMTKLAQGRL DLHSKREAID FRWLAELYCS IGGKAESGMS
     VRTANTALEV LQMAQAEHVP IAPAIARSAC RVAAGALARA DIALDVAIFD RDGCLIASER
     C