ID   YIDC_STACT              Reviewed;         289 AA.
AC   Q9RGS4; B9DMG7;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01811};
DE   Flags: Precursor;
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01811}; OrderedLocusNames=Sca_1592;
OS   Staphylococcus carnosus (strain TM300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=396513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TM300;
RX   PubMed=19060169; DOI=10.1128/aem.01982-08;
RA   Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C.,
RA   Goetz F.;
RT   "Genome analysis of the meat starter culture bacterium Staphylococcus
RT   carnosus TM300.";
RL   Appl. Environ. Microbiol. 75:811-822(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-225.
RA   Krismer B., Goetz F.;
RT   "Identification of an operon involved in thiamin biosynthesis in
RT   Staphylococcus carnosus TM300.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. {ECO:0000255|HAMAP-Rule:MF_01811}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01811};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01811}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01811}.
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DR   EMBL; AM295250; CAL28497.1; -; Genomic_DNA.
DR   EMBL; AF109218; AAF25545.1; -; Genomic_DNA.
DR   RefSeq; WP_015900837.1; NC_012121.1.
DR   AlphaFoldDB; Q9RGS4; -.
DR   SMR; Q9RGS4; -.
DR   STRING; 396513.SCA_1592; -.
DR   GeneID; 60544696; -.
DR   KEGG; sca:SCA_1592; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_036138_5_2_9; -.
DR   OMA; GWAIIII; -.
DR   OrthoDB; 524437at2; -.
DR   BioCyc; SCAR396513:SCA_RS08085-MON; -.
DR   Proteomes; UP000000444; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01811; YidC_type2; 1.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW   Protein transport; Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   CHAIN           20..289
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000020397"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   REGION          268..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           20
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   LIPID           20
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   CONFLICT        223
FT                   /note="S -> T (in Ref. 2; AAF25545)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   289 AA;  32825 MW;  1FE8CF036304D661 CRC64;
     MKKKALLPLL LGIMVFLAGC DYSKPENRTG FFYNTFVKNM DNIIHWLGAS FNNDYGLAII
     VLVLAIRIIV LPFMLSNYKN SHMMREKMII AKPDMDAVKE KVQRARTQED KMAANQEMME
     VYKKYDMNPM QSMLGCLPML IQMPIIMGLF FVLKYPSPGG ITEHSHFLWF NLAKPDIWIT
     VIAGVLYFLQ AYVSTFSMPP EQKQMSYMMM IISPIMIIWV SLSSAAALGL YWSVSAAFLI
     VQTYIANAYY SKKAKEEVAP MIAAYEKEHG GSGNSKGAKV VSKKNKKKK