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YIDC_STRCO
ID   YIDC_STRCO              Reviewed;         431 AA.
AC   O54569;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=SCO3883; ORFNames=STH24.05;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=1577691; DOI=10.1128/jb.174.10.3220-3226.1992;
RA   Calcutt M.J., Schmidt F.J.;
RT   "Conserved gene arrangement in the origin region of the Streptomyces
RT   coelicolor chromosome.";
RL   J. Bacteriol. 174:3220-3226(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=9795152; DOI=10.1016/s0378-1119(98)00357-6;
RA   Gal-Mor O., Borovok I., Av-Gay Y., Cohen G., Aharonowitz Y.;
RT   "Gene organization in the trxA/B-oriC region of the Streptomyces coelicolor
RT   chromosome and comparison with other eubacteria.";
RL   Gene 217:83-90(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF187159; AAF16008.1; -; Genomic_DNA.
DR   EMBL; AF031590; AAC03487.1; -; Genomic_DNA.
DR   EMBL; AL939118; CAB42700.1; -; Genomic_DNA.
DR   PIR; T36570; T36570.
DR   RefSeq; NP_628069.1; NC_003888.3.
DR   RefSeq; WP_011029289.1; NZ_VNID01000003.1.
DR   AlphaFoldDB; O54569; -.
DR   SMR; O54569; -.
DR   STRING; 100226.SCO3883; -.
DR   GeneID; 1099319; -.
DR   KEGG; sco:SCO3883; -.
DR   PATRIC; fig|100226.15.peg.3956; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_036138_3_1_11; -.
DR   InParanoid; O54569; -.
DR   OMA; ERYKNDR; -.
DR   PhylomeDB; O54569; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR   GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..431
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124756"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          337..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..373
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..388
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        409..423
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   431 AA;  47373 MW;  6E6D2E04D3EC4D65 CRC64;
     MDTIASLFSF ITWPVSWVIV QFHTVYGAIF GPDTGWAWGL SIVSLVILIR ICLIPLFVKQ
     IKATRGMQTL QPEMKKIQER YKNDKQRQSE EMMKLYKETG TNPLSSCLPI LAQSPFFFAL
     YHVLNGIASG DTIGKINQPL LESAQKAHIF GAPLAAKFTD GASKVESLGA SLTDVRVITA
     VMIVLMSASQ FFTQRQLMTK NVDTSVKTPF MQQQKMLMYV FPVMFAVFGI NFPVGVLVYW
     LTTNVWTMGQ QMYVIRNNPT PGSKAQASYL ERLHKSVTEH GRTRRRGEKA IVKAIVAKGR
     DRNEAERKFI NGLNKAGLAA QADGNVVKND AAVAVQSEDG STVTTTAQPK RQQPKRQSKS
     QRQAKPAGET EPKTSLTKSD EPQDAEPAGK QDAKPAAGAK KPAQKSGGGG RSKAQSGQRK
     GPQRPKSPSK K
 
 
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