YIDC_THEMA
ID YIDC_THEMA Reviewed; 445 AA.
AC Q9X1H2;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=TM_1461;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR EMBL; AE000512; AAD36529.1; -; Genomic_DNA.
DR PIR; F72251; F72251.
DR RefSeq; NP_229260.1; NC_000853.1.
DR RefSeq; WP_010865347.1; NZ_CP011107.1.
DR PDB; 5Y82; X-ray; 2.52 A; A/B/C/D=24-222.
DR PDB; 5Y83; X-ray; 3.84 A; A=1-445.
DR PDB; 6Y86; X-ray; 3.40 A; A=1-425.
DR PDBsum; 5Y82; -.
DR PDBsum; 5Y83; -.
DR PDBsum; 6Y86; -.
DR AlphaFoldDB; Q9X1H2; -.
DR SMR; Q9X1H2; -.
DR STRING; 243274.THEMA_07010; -.
DR DNASU; 898017; -.
DR EnsemblBacteria; AAD36529; AAD36529; TM_1461.
DR KEGG; tma:TM1461; -.
DR eggNOG; COG0706; Bacteria.
DR InParanoid; Q9X1H2; -.
DR OMA; NFGWAII; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell inner membrane; Cell membrane; Chaperone; Membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..445
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124760"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT HELIX 2..7
FT /evidence="ECO:0007829|PDB:6Y86"
FT TURN 8..11
FT /evidence="ECO:0007829|PDB:6Y86"
FT HELIX 14..18
FT /evidence="ECO:0007829|PDB:6Y86"
FT STRAND 25..28
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 33..36
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 38..44
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 46..48
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 51..56
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 62..66
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 74..78
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 88..90
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 96..98
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 100..108
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 110..119
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 122..139
FT /evidence="ECO:0007829|PDB:5Y82"
FT HELIX 147..149
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 150..153
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 156..161
FT /evidence="ECO:0007829|PDB:5Y82"
FT TURN 162..165
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 166..171
FT /evidence="ECO:0007829|PDB:5Y82"
FT STRAND 180..196
FT /evidence="ECO:0007829|PDB:5Y82"
FT HELIX 199..205
FT /evidence="ECO:0007829|PDB:5Y82"
FT TURN 207..209
FT /evidence="ECO:0007829|PDB:5Y82"
FT HELIX 210..217
FT /evidence="ECO:0007829|PDB:5Y82"
FT TURN 221..223
FT /evidence="ECO:0007829|PDB:6Y86"
FT HELIX 228..245
FT /evidence="ECO:0007829|PDB:6Y86"
FT HELIX 248..262
FT /evidence="ECO:0007829|PDB:6Y86"
FT HELIX 266..279
FT /evidence="ECO:0007829|PDB:6Y86"
FT HELIX 282..285
FT /evidence="ECO:0007829|PDB:6Y86"
FT STRAND 294..296
FT /evidence="ECO:0007829|PDB:6Y86"
FT HELIX 301..305
FT /evidence="ECO:0007829|PDB:6Y86"
FT HELIX 314..333
FT /evidence="ECO:0007829|PDB:6Y86"
FT HELIX 337..342
FT /evidence="ECO:0007829|PDB:6Y86"
FT STRAND 346..348
FT /evidence="ECO:0007829|PDB:6Y86"
FT HELIX 357..377
FT /evidence="ECO:0007829|PDB:6Y86"
FT HELIX 383..392
FT /evidence="ECO:0007829|PDB:6Y86"
FT HELIX 395..398
FT /evidence="ECO:0007829|PDB:6Y86"
FT TURN 399..401
FT /evidence="ECO:0007829|PDB:6Y86"
FT HELIX 404..421
FT /evidence="ECO:0007829|PDB:6Y86"
SQ SEQUENCE 445 AA; 51421 MW; 465A3CCAF62579F2 CRC64;
MVLRKVVAIL LAILPIFLFA VEPIKVVRSE KEIVVLTRFE EYHFDLEKGI LKDFYTLVDG
RKHVFTYGND GFDVLDEGTP LTVIEEPIVT GVGKVSEGFS DEVSIVYNYG YVKKIFTIKN
NENYTFFVDI ESSKPVDVTV PRVSVDTSTD RYLENYFASF NPKTRTLVLL KHDEGLLFEG
TLKVNGQKRF IVFMGPNKRT LIKKAFPEDY DVLIKALVNI PGFNKWYDSV FYGLVWFFWW
LKDLTKNFGW AIMLFTLIVR LILYPLYHAQ TKSLINMRKL QPQIEAIKKK YKDPTKQQEA
LLKLYREAGV NPASGCLMLL IQLPIFMLLW SVIRYYVEEF AYSGSFLIWK DLSAGGFSNN
WLFLVITIVA SYYTTLLTSQ DARTAWQGII MSVIFPFLFV GLPSGLFLYY ATNTLIQLAV
TYYTYKRYKI KGLTTRELLG LPKKA
