ID   YIDC_THEVB              Reviewed;         401 AA.
AC   Q8DL96;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=tll0600;
OS   Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1).
OC   Bacteria; Cyanobacteria; Pseudanabaenales; Thermosynechococcaceae;
OC   Thermosynechococcus.
OX   NCBI_TaxID=197221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-2133 / IAM M-273 / BP-1;
RX   PubMed=12240834; DOI=10.1093/dnares/9.4.123;
RA   Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S.,
RA   Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C.,
RA   Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of the thermophilic cyanobacterium
RT   Thermosynechococcus elongatus BP-1.";
RL   DNA Res. 9:123-130(2002).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Probably also aids protein insertion, folding and/or assembly
CC       of membrane complexes destined for the thylakoid. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BA000039; BAC08152.1; -; Genomic_DNA.
DR   RefSeq; NP_681390.1; NC_004113.1.
DR   RefSeq; WP_011056448.1; NC_004113.1.
DR   AlphaFoldDB; Q8DL96; -.
DR   STRING; 197221.22294322; -.
DR   PRIDE; Q8DL96; -.
DR   EnsemblBacteria; BAC08152; BAC08152; BAC08152.
DR   KEGG; tel:tll0600; -.
DR   PATRIC; fig|197221.4.peg.634; -.
DR   eggNOG; COG0706; Bacteria.
DR   OMA; KITPVMI; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000000440; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..401
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124757"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          375..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   401 AA;  44356 MW;  029E023AD6E766DF CRC64;
     MDFGIGFLSN NVMLPILDFF YGIVPSYGLA IVALTLVVRF AVYPLSAGSI RNMRRMKVVQ
     PIMQKRMQEI QQKYKDNPAE QQKAMAEVYR EFGNPLAGCF PLLLQLPILF ALFATLRGSP
     FADVNYQINL QIVPPDQPVL AQPFATKPQN IYVDEGVHFP IQAVVPSGTR IPVGQMVDLQ
     FQTKEGKPFS ELVAAYPNSH LQPKWQIIRG QERATIDREG HLQALQPGEV TVQGTIPGIA
     ADKGFLFISA LGHVGVIDQG ELFITLPDGA RQFNWGAIHW DILVMILGFG VSLYVNQLLS
     GQGSSNNPQQ QTVNQLTPII FSGMFLFFPL PAGVLLYMLI ANIFQTVQTF ILQREPLPEN
     LQKLVEEQER AEAIKNRAPL PFEGKGAKGA KATKAKGNPS S