YIDC_TREPA
ID YIDC_TREPA Reviewed; 622 AA.
AC O66103; O83915;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=TP_0949;
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX NCBI_TaxID=243276;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 456-622.
RA Shevchenko D.V., Akins D.R., Radolf J.D.;
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC65906.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE000520; AAC65906.1; ALT_INIT; Genomic_DNA.
DR EMBL; U97573; AAC08053.1; -; Genomic_DNA.
DR PIR; C71261; C71261.
DR RefSeq; WP_014342847.1; NC_021490.2.
DR AlphaFoldDB; O66103; -.
DR SMR; O66103; -.
DR STRING; 243276.TPANIC_0949; -.
DR EnsemblBacteria; AAC65906; AAC65906; TP_0949.
DR KEGG; tpa:TP_0949; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_016535_2_0_12; -.
DR OMA; MPIMFFF; -.
DR OrthoDB; 524437at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..622
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124761"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 483..503
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 513..533
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 579..599
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT REGION 37..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 70121 MW; 04C70CA8E8646E8C CRC64;
MKKNMFIAVV LSVLVLVGAS FLQELLYPSA SSSHSAAEHT LSAVPEETRT QSAHGGAADT
QETTQPAAHP SGQVLVFPES ETEERVERTY VVRTPLVQVT FTNRGGDILS YQLREHYAAQ
RREYVEMVEQ ARPDHRAFSL ALGDEYAPNV NALFQVKQEI GARGVHSIGF YRSVATQHAD
GTRTPFVLAK RYVFYPDNYM FELHVSLSAD VLEEREDSRQ GAKVRAVAET NAGPATTVLA
RANGFDFGTA SYTLRTPPEI GPERNAADKY EFRTFMVGAG GKAKTYALKG DGREQVDTPV
SWASVSGKYF ALIVLPNDAD SLKRLVLSAP QAETAVQHHI AFVRRAVAQP AVADVYRVYI
GPCAEQYLSA YNVASRNPYG LERTYIDAVA VSGGILYPLE VLLKWLLRLF YTLIPNWGVA
IILVTIAIKV LFFPLTKRSF IAMQKMQELQ PHMQRIQERY KGNTQKIHEE MAKLYREAQY
NPLSGCLPTL VQMPIIFAMY RLFNNYFEFR GAMFIPYWIP DLSLADSVWT LPFALPVTQW
TQMRMLPVLY VVSQIMFSKL TQVPHTEQQK TSMTIMTYVM PLFFFFFFYD APSGLLVYWT
AMNGVTLVQQ LVMKRTANKN KT
