ID   YIDC_TROW8              Reviewed;         310 AA.
AC   Q83N53;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=TW815;
OS   Tropheryma whipplei (strain TW08/27) (Whipple's bacillus).
OC   Bacteria; Actinobacteria; Micrococcales; Tropherymataceae; Tropheryma.
OX   NCBI_TaxID=218496;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW08/27;
RX   PubMed=12606174; DOI=10.1016/s0140-6736(03)12597-4;
RA   Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G.,
RA   Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A.,
RA   Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J.,
RA   Relman D.A.;
RT   "Sequencing and analysis of the genome of the Whipple's disease bacterium
RT   Tropheryma whipplei.";
RL   Lancet 361:637-644(2003).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BX251412; CAD67474.1; -; Genomic_DNA.
DR   RefSeq; WP_011096752.1; NC_004551.1.
DR   AlphaFoldDB; Q83N53; -.
DR   GeneID; 67388595; -.
DR   KEGG; tws:TW815; -.
DR   HOGENOM; CLU_036138_3_1_11; -.
DR   OMA; ERYKNDR; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..310
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124762"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          290..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   310 AA;  35033 MW;  051CB56F6B00AD62 CRC64;
     MFDGLFDFLQ NILLPIKWVI EQILVFFHTL LGFLGFGDKS GLSWALSIVG LVIVIRATLI
     PVFLKQIRAQ RKMLEIAPEV RRIQEKYKGK RDVLSRQSMN QEMMEIYRVR GANPLSSCLP
     IVLQMPVFFG LYQVIESAQN AGTGVGPLNG PLGMDFRDSR IFGVVPLHDS FSHDFYALQA
     GQAFNLITMI VAGVLTAIMI AVQLFTQLKV IPKNIPENAK NTSVYKNQKV MLYLLPIMFL
     GMGFSFPVGI LIYWTASNVW SGVQQAVAIY RNPSPGSLAF ELRRKRLGVQ NKKTKGQRQQ
     PVNKRRAKRR