ID   YIDC_XYLF2              Reviewed;         565 AA.
AC   B2IAR7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   OrderedLocusNames=XfasM23_2224;
OS   Xylella fastidiosa (strain M23).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xylella.
OX   NCBI_TaxID=405441;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M23;
RX   PubMed=20601474; DOI=10.1128/jb.00651-10;
RA   Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.;
RT   "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23)
RT   causing almond leaf scorch disease in California.";
RL   J. Bacteriol. 192:4534-4534(2010).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; CP001011; ACB93617.1; -; Genomic_DNA.
DR   RefSeq; WP_004087831.1; NC_010577.1.
DR   AlphaFoldDB; B2IAR7; -.
DR   SMR; B2IAR7; -.
DR   EnsemblBacteria; ACB93617; ACB93617; XfasM23_2224.
DR   GeneID; 58017635; -.
DR   KEGG; xfn:XfasM23_2224; -.
DR   HOGENOM; CLU_016535_3_0_6; -.
DR   OMA; INPVAGC; -.
DR   Proteomes; UP000001698; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..565
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_1000187717"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        479..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        516..536
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   565 AA;  64379 MW;  638D9221AC3AC8E9 CRC64;
     MNQTRVLLIF SWLTVATLLW MDWSKNKNET LEISASHNLG VDSNLELEHA VPQIHAGAVP
     LQKDSQLIAA APKVPVINVT TDVLQLKLDG FSILAADLLR FPQSKDRGAK PIKLLTDDPN
     YPYSATTGWV SQSNSPVPNL STFLPEQPDV SYKLANDQNR LVVPFIWTAA NGVSIRRTFT
     FERGRYAILI RDEIRNSGET PWNAYVFRKL SRVPIPNILN RAMTNPDSFS FNGAVWYSEK
     GGYERRAFKD YMNDGGLNRE IGGGWIALLQ HHFFTAWIPQ KDQASLYLLA QNGSRDIAEL
     RGPAFTVAPG QTTTTEARLW VGPKLVEQIT KEHVKGLDRV VDYSRFQLMA LIGQGLFWIL
     SHLNSLLHNW GWAIVGLVVL LRIAMYPLSA SQYKSAAKMR KFQPRLQQLK ERYGEDRQKF
     QQAMMELYKK EKINPMGGCF PILIQMPIFF ALYWVLVESV ELRQAPWLGW IQDLTTRDPY
     FILPLLNIVI MWATQKLTPT PAGMDPIAGK MMQVMPLIFG VMMAFVPSGL ALYWVINGGL
     NLLIQWWMIR QHADFSRKRS RENIK