YIDC_ZYMMO
ID YIDC_ZYMMO Reviewed; 579 AA.
AC Q9RNL5; Q5NM10;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=ZMO1626;
OS Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC Zymomonadaceae; Zymomonas.
OX NCBI_TaxID=264203;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 31821 / ZM4 / CP4;
RA Lee H.J., Kang H.S.;
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31821 / ZM4 / CP4;
RX PubMed=15592456; DOI=10.1038/nbt1045;
RA Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H.,
RA Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J.,
RA Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y., Kang H.L., Lee S.Y., Lee K.J.,
RA Kang H.S.;
RT "The genome sequence of the ethanologenic bacterium Zymomonas mobilis
RT ZM4.";
RL Nat. Biotechnol. 23:63-68(2005).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR EMBL; AF180145; AAD56912.1; -; Genomic_DNA.
DR EMBL; AE008692; AAV90250.1; -; Genomic_DNA.
DR RefSeq; WP_011241376.1; NZ_CP035711.1.
DR AlphaFoldDB; Q9RNL5; -.
DR SMR; Q9RNL5; -.
DR STRING; 264203.ZMO1626; -.
DR EnsemblBacteria; AAV90250; AAV90250; ZMO1626.
DR GeneID; 58027341; -.
DR KEGG; zmo:ZMO1626; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_016535_1_0_5; -.
DR OMA; INPVAGC; -.
DR OrthoDB; 524437at2; -.
DR Proteomes; UP000001173; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..579
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124776"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 523..543
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT REGION 35..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 167
FT /note="F -> L (in Ref. 1; AAD56912)"
FT /evidence="ECO:0000305"
FT CONFLICT 172
FT /note="S -> C (in Ref. 1; AAD56912)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 579 AA; 65988 MW; D7187B589EF6CFAD CRC64;
MDDKHQQRNL VIVTILSALI LFGWSFVTKH WLSTPPAPTQ QGKNQPKAEL TAEESGDKPL
KPVDQVLQET PRLPILTESV EGSVNLKGLR LDDLTLIRHR ETLAKNSPAV RLFSPAGTEN
AWFTSFGWTG ENVALPNADS LWKADSDKLT ADHPVNFYWN NQQGQIFRIT LSVDHDYMFN
ATESVINRGN SPVIVQPYVL TNHQGVFKTA SSWTLHTGPI GVFNGSVNYH VDFADIDKAT
NNSIRNNTQG GWIGFSDKYW LTALAPHNQK IAIDTDFRSS SNHHYQADFT VAPVVVAAGK
TASTSVDVFA GAKEVRVLDR YRDQLHLPHF DKAIDWGWFA IIEKVFFYYL DWLFLHVGNY
GLAIILMVFT IRALIFPIAN KQYASMASMR RLQPKMQAVR ERYKNDEARM RQELVTLYQK
EKVNPFAGCL PMFIQFPIFI ALYKTLLVTI ESRHQPFILW IKDLSAPDPL TPFNLFGLLH
FTPPHFLMIG VLPIILGITM WLQFRASPQQ LEPAQQQIMS FLPLISVIFM APLAAGLQVY
YIFNNLISLA QMMWLQHRHS TPEERQDRAE RKRPSKKKA
