CBID_PHOLL
ID CBID_PHOLL Reviewed; 378 AA.
AC Q7N2S8;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Cobalt-precorrin-5B C(1)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_00787};
DE EC=2.1.1.195 {ECO:0000255|HAMAP-Rule:MF_00787};
DE AltName: Full=Cobalt-precorrin-6A synthase {ECO:0000255|HAMAP-Rule:MF_00787};
GN Name=cbiD {ECO:0000255|HAMAP-Rule:MF_00787}; OrderedLocusNames=plu2996;
OS Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS TT01).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=243265;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15139 / CIP 105565 / TT01;
RX PubMed=14528314; DOI=10.1038/nbt886;
RA Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA Glaser P., Boemare N., Danchin A., Kunst F.;
RT "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT luminescens.";
RL Nat. Biotechnol. 21:1307-1313(2003).
CC -!- FUNCTION: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to
CC form cobalt-precorrin-6A. {ECO:0000255|HAMAP-Rule:MF_00787}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A +
CC S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:26285, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:60063, ChEBI:CHEBI:60064;
CC EC=2.1.1.195; Evidence={ECO:0000255|HAMAP-Rule:MF_00787};
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC step 6/10. {ECO:0000255|HAMAP-Rule:MF_00787}.
CC -!- SIMILARITY: Belongs to the CbiD family. {ECO:0000255|HAMAP-
CC Rule:MF_00787}.
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DR EMBL; BX571869; CAE15370.1; -; Genomic_DNA.
DR RefSeq; WP_011147215.1; NC_005126.1.
DR AlphaFoldDB; Q7N2S8; -.
DR SMR; Q7N2S8; -.
DR STRING; 243265.plu2996; -.
DR EnsemblBacteria; CAE15370; CAE15370; plu2996.
DR GeneID; 24170188; -.
DR KEGG; plu:plu2996; -.
DR eggNOG; COG1903; Bacteria.
DR HOGENOM; CLU_041273_1_0_6; -.
DR OMA; YHGKLIK; -.
DR OrthoDB; 1282567at2; -.
DR BioCyc; PLUM243265:PLU_RS14900-MON; -.
DR UniPathway; UPA00148; UER00227.
DR Proteomes; UP000002514; Chromosome.
DR GO; GO:0043780; F:cobalt-precorrin-5B C1-methyltransferase activity; IEA:RHEA.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0046140; P:corrin biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2110.10; -; 1.
DR HAMAP; MF_00787; CbiD; 1.
DR InterPro; IPR002748; CbiD.
DR InterPro; IPR036074; CbiD_sf.
DR PANTHER; PTHR35863; PTHR35863; 1.
DR Pfam; PF01888; CbiD; 1.
DR PIRSF; PIRSF026782; CbiD; 1.
DR SUPFAM; SSF111342; SSF111342; 1.
DR TIGRFAMs; TIGR00312; cbiD; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis; Methyltransferase; Reference proteome;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..378
FT /note="Cobalt-precorrin-5B C(1)-methyltransferase"
FT /id="PRO_0000141674"
SQ SEQUENCE 378 AA; 41071 MW; B155F708834C56B0 CRC64;
MSDTMQLDSI WHNGKQYRKG YTTGSCATAA AKVAALMVLR QQVIDHVSIV TPSGVTLRLN
VEQPLIEGQQ ATAAIRKDGG DDVDATHGML IFARVTLCDH GEIHLRGGEG VGTVTRKGVG
LPVGSSAINR TPRQTIEAAV REAIGPLRGA EVEIFAPEGE ERAKKTYNGR LGILGGISII
GTTGIVTPMS EESWKRSLAI ELEMKRSAGA EKVILVPGNH GERFVREQLG LDGQLVVTMS
NFVGYMLQEA VRLGFRHIML VGHPGKLVKV AAGIFHTHSH IADGRMETLI AYLALMGASQ
ELLLEVSHCD TTEAAMELIA EHGLQAVYDR IAERICERMS EMLRFAVNPP RCDAIMFSFD
NQILGTSRPL NDILEAMR
