YIF1A_HUMAN
ID YIF1A_HUMAN Reviewed; 293 AA.
AC O95070; A6NM00; Q96G83; Q9BVD0;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Protein YIF1A;
DE AltName: Full=54TMp;
DE AltName: Full=YIP1-interacting factor homolog A;
GN Name=YIF1A; Synonyms=54TM, HYIF1P, YIF1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=T-cell;
RA Wilson L.A., Field D., Cruz L., Friesen J., Siminovitch K.A.;
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=15308636; DOI=10.1074/jbc.m406644200;
RA Breuza L., Halbeisen R., Jenoe P., Otte S., Barlowe C., Hong W.,
RA Hauri H.-P.;
RT "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC)
RT membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new
RT cycling protein that interacts with human Erv46.";
RL J. Biol. Chem. 279:47242-47253(2004).
RN [7]
RP FUNCTION, INTERACTION WITH YIPF5, AND SUBCELLULAR LOCATION.
RX PubMed=15990086; DOI=10.1016/j.bbrc.2005.06.051;
RA Jin C., Zhang Y., Zhu H., Ahmed K., Fu C., Yao X.;
RT "Human Yip1A specifies the localization of Yif1 to the Golgi apparatus.";
RL Biochem. Biophys. Res. Commun. 334:16-22(2005).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE
RP ANALYSIS] AT SER-12, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE
RP ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP SUBCELLULAR LOCATION.
RX PubMed=26077767; DOI=10.1111/tra.12306;
RA Alterio J., Masson J., Diaz J., Chachlaki K., Salman H., Areias J.,
RA Al Awabdh S., Emerit M.B., Darmon M.;
RT "Yif1B Is Involved in the Anterograde Traffic Pathway and the Golgi
RT Architecture.";
RL Traffic 16:978-993(2015).
CC -!- FUNCTION: Possible role in transport between endoplasmic reticulum and
CC Golgi. {ECO:0000269|PubMed:15990086}.
CC -!- SUBUNIT: Interacts with YIPF5. {ECO:0000269|PubMed:15990086}.
CC -!- INTERACTION:
CC O95070; Q6Q788: APOA5; NbExp=3; IntAct=EBI-2799703, EBI-3936819;
CC O95070; Q13520: AQP6; NbExp=3; IntAct=EBI-2799703, EBI-13059134;
CC O95070; Q9NQ11: ATP13A2; NbExp=2; IntAct=EBI-2799703, EBI-6308763;
CC O95070; Q12982: BNIP2; NbExp=3; IntAct=EBI-2799703, EBI-752094;
CC O95070; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-2799703, EBI-12003442;
CC O95070; P55212: CASP6; NbExp=3; IntAct=EBI-2799703, EBI-718729;
CC O95070; P11912: CD79A; NbExp=3; IntAct=EBI-2799703, EBI-7797864;
CC O95070; Q96G23: CERS2; NbExp=3; IntAct=EBI-2799703, EBI-1057080;
CC O95070; Q96F85: CNRIP1; NbExp=3; IntAct=EBI-2799703, EBI-958255;
CC O95070; Q15828: CST6; NbExp=3; IntAct=EBI-2799703, EBI-7163527;
CC O95070; Q15125: EBP; NbExp=3; IntAct=EBI-2799703, EBI-3915253;
CC O95070; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-2799703, EBI-18535450;
CC O95070; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-2799703, EBI-781551;
CC O95070; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-2799703, EBI-18938272;
CC O95070; O95363: FARS2; NbExp=3; IntAct=EBI-2799703, EBI-2513774;
CC O95070; O15552: FFAR2; NbExp=3; IntAct=EBI-2799703, EBI-2833872;
CC O95070; O60861-1: GAS7; NbExp=3; IntAct=EBI-2799703, EBI-11745923;
CC O95070; P48165: GJA8; NbExp=3; IntAct=EBI-2799703, EBI-17458373;
CC O95070; O15354: GPR37; NbExp=2; IntAct=EBI-2799703, EBI-15639515;
CC O95070; O15529: GPR42; NbExp=3; IntAct=EBI-2799703, EBI-18076404;
CC O95070; Q8TED1: GPX8; NbExp=3; IntAct=EBI-2799703, EBI-11721746;
CC O95070; P28799: GRN; NbExp=3; IntAct=EBI-2799703, EBI-747754;
CC O95070; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-2799703, EBI-1052304;
CC O95070; P42858: HTT; NbExp=12; IntAct=EBI-2799703, EBI-466029;
CC O95070; Q8TAC2: JOSD2; NbExp=3; IntAct=EBI-2799703, EBI-12205593;
CC O95070; P13473-2: LAMP2; NbExp=3; IntAct=EBI-2799703, EBI-21591415;
CC O95070; Q9C0E8-2: LNPK; NbExp=3; IntAct=EBI-2799703, EBI-11024283;
CC O95070; P48449: LSS; NbExp=3; IntAct=EBI-2799703, EBI-3930711;
CC O95070; Q9NX47: MARCHF5; NbExp=3; IntAct=EBI-2799703, EBI-2341610;
CC O95070; O14880: MGST3; NbExp=3; IntAct=EBI-2799703, EBI-724754;
CC O95070; Q96C03-3: MIEF2; NbExp=3; IntAct=EBI-2799703, EBI-11988931;
CC O95070; Q03111: MLLT1; NbExp=3; IntAct=EBI-2799703, EBI-1384215;
CC O95070; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-2799703, EBI-6163737;
CC O95070; Q15800: MSMO1; NbExp=3; IntAct=EBI-2799703, EBI-949102;
CC O95070; Q96E29: MTERF3; NbExp=3; IntAct=EBI-2799703, EBI-7825321;
CC O95070; Q9HB07: MYG1; NbExp=3; IntAct=EBI-2799703, EBI-709754;
CC O95070; Q9ULP0-2: NDRG4; NbExp=3; IntAct=EBI-2799703, EBI-11978907;
CC O95070; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-2799703, EBI-742388;
CC O95070; P30405: PPIF; NbExp=3; IntAct=EBI-2799703, EBI-5544229;
CC O95070; O14684: PTGES; NbExp=3; IntAct=EBI-2799703, EBI-11161398;
CC O95070; P43378: PTPN9; NbExp=3; IntAct=EBI-2799703, EBI-742898;
CC O95070; P62826: RAN; NbExp=3; IntAct=EBI-2799703, EBI-286642;
CC O95070; Q8N0V3: RBFA; NbExp=3; IntAct=EBI-2799703, EBI-3232108;
CC O95070; Q9BRK0: REEP2; NbExp=3; IntAct=EBI-2799703, EBI-11337973;
CC O95070; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-2799703, EBI-7545592;
CC O95070; Q7Z5B4-5: RIC3; NbExp=3; IntAct=EBI-2799703, EBI-12375429;
CC O95070; P50876: RNF144A; NbExp=3; IntAct=EBI-2799703, EBI-2340657;
CC O95070; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-2799703, EBI-17247926;
CC O95070; Q8IWT1: SCN4B; NbExp=3; IntAct=EBI-2799703, EBI-23705473;
CC O95070; O00560: SDCBP; NbExp=3; IntAct=EBI-2799703, EBI-727004;
CC O95070; Q9Y6Y8: SEC23IP; NbExp=3; IntAct=EBI-2799703, EBI-1767971;
CC O95070; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-2799703, EBI-2623095;
CC O95070; Q14973: SLC10A1; NbExp=3; IntAct=EBI-2799703, EBI-3923031;
CC O95070; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-2799703, EBI-17295964;
CC O95070; Q9Y5X0: SNX10; NbExp=3; IntAct=EBI-2799703, EBI-10329478;
CC O95070; Q9Y5W9: SNX11; NbExp=3; IntAct=EBI-2799703, EBI-10329449;
CC O95070; O60749: SNX2; NbExp=3; IntAct=EBI-2799703, EBI-1046690;
CC O95070; Q9HCH5-13: SYTL2; NbExp=3; IntAct=EBI-2799703, EBI-14291493;
CC O95070; Q8TDW5-2: SYTL5; NbExp=3; IntAct=EBI-2799703, EBI-12243980;
CC O95070; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-2799703, EBI-6268651;
CC O95070; Q8IV31: TMEM139; NbExp=3; IntAct=EBI-2799703, EBI-7238458;
CC O95070; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-2799703, EBI-8638294;
CC O95070; Q86X19: TMEM17; NbExp=4; IntAct=EBI-2799703, EBI-11343485;
CC O95070; P0DP42: TMEM225B; NbExp=3; IntAct=EBI-2799703, EBI-18398510;
CC O95070; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-2799703, EBI-10314986;
CC O95070; Q9Y320: TMX2; NbExp=3; IntAct=EBI-2799703, EBI-6447886;
CC O95070; Q9P0L0: VAPA; NbExp=3; IntAct=EBI-2799703, EBI-1059156;
CC O95070; O95292: VAPB; NbExp=9; IntAct=EBI-2799703, EBI-1188298;
CC O95070; Q3ZAQ7: VMA21; NbExp=3; IntAct=EBI-2799703, EBI-1055364;
CC O95070; Q96P53: WDFY2; NbExp=3; IntAct=EBI-2799703, EBI-9478589;
CC O95070; O76024: WFS1; NbExp=3; IntAct=EBI-2799703, EBI-720609;
CC O95070; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-2799703, EBI-751253;
CC O95070; Q969M3: YIPF5; NbExp=8; IntAct=EBI-2799703, EBI-2124787;
CC O95070; Q969W1: ZDHHC16; NbExp=3; IntAct=EBI-2799703, EBI-11572692;
CC O95070; Q9BQ24: ZFYVE21; NbExp=3; IntAct=EBI-2799703, EBI-2849569;
CC O95070; Q5T4F4: ZFYVE27; NbExp=3; IntAct=EBI-2799703, EBI-3892947;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:15308636}; Multi-pass membrane protein
CC {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:15308636,
CC ECO:0000269|PubMed:15990086, ECO:0000269|PubMed:26077767}; Multi-pass
CC membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000269|PubMed:26077767}; Multi-
CC pass membrane protein {ECO:0000255}. Note=Cycles between the
CC endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate
CC compartment. {ECO:0000269|PubMed:15308636}.
CC -!- SIMILARITY: Belongs to the YIF1 family. {ECO:0000305}.
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DR EMBL; AF004876; AAD01206.1; -; mRNA.
DR EMBL; CR456710; CAG32991.1; -; mRNA.
DR EMBL; AP001107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471076; EAW74509.1; -; Genomic_DNA.
DR EMBL; BC001299; AAH01299.1; -; mRNA.
DR EMBL; BC009892; AAH09892.2; -; mRNA.
DR CCDS; CCDS8132.1; -.
DR RefSeq; NP_065203.2; NM_020470.2.
DR AlphaFoldDB; O95070; -.
DR BioGRID; 116103; 126.
DR IntAct; O95070; 97.
DR MINT; O95070; -.
DR STRING; 9606.ENSP00000366098; -.
DR GlyGen; O95070; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; O95070; -.
DR PhosphoSitePlus; O95070; -.
DR BioMuta; YIF1A; -.
DR EPD; O95070; -.
DR jPOST; O95070; -.
DR MassIVE; O95070; -.
DR MaxQB; O95070; -.
DR PaxDb; O95070; -.
DR PeptideAtlas; O95070; -.
DR PRIDE; O95070; -.
DR ProteomicsDB; 50640; -.
DR TopDownProteomics; O95070; -.
DR Antibodypedia; 3107; 41 antibodies from 14 providers.
DR DNASU; 10897; -.
DR Ensembl; ENST00000376901.9; ENSP00000366098.4; ENSG00000174851.16.
DR GeneID; 10897; -.
DR KEGG; hsa:10897; -.
DR MANE-Select; ENST00000376901.9; ENSP00000366098.4; NM_020470.3; NP_065203.2.
DR UCSC; uc001ohk.5; human.
DR CTD; 10897; -.
DR DisGeNET; 10897; -.
DR GeneCards; YIF1A; -.
DR HGNC; HGNC:16688; YIF1A.
DR HPA; ENSG00000174851; Low tissue specificity.
DR MIM; 611484; gene.
DR neXtProt; NX_O95070; -.
DR OpenTargets; ENSG00000174851; -.
DR PharmGKB; PA134985105; -.
DR VEuPathDB; HostDB:ENSG00000174851; -.
DR eggNOG; KOG3094; Eukaryota.
DR GeneTree; ENSGT00390000009423; -.
DR InParanoid; O95070; -.
DR OMA; SHYFQVS; -.
DR OrthoDB; 1256839at2759; -.
DR PhylomeDB; O95070; -.
DR TreeFam; TF314528; -.
DR PathwayCommons; O95070; -.
DR Reactome; R-HSA-381038; XBP1(S) activates chaperone genes.
DR SignaLink; O95070; -.
DR BioGRID-ORCS; 10897; 21 hits in 1089 CRISPR screens.
DR GeneWiki; YIF1A; -.
DR GenomeRNAi; 10897; -.
DR Pharos; O95070; Tdark.
DR PRO; PR:O95070; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; O95070; protein.
DR Bgee; ENSG00000174851; Expressed in stromal cell of endometrium and 172 other tissues.
DR ExpressionAtlas; O95070; baseline and differential.
DR Genevisible; O95070; HS.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR005578; Yif1_fam.
DR PANTHER; PTHR14083; PTHR14083; 1.
DR Pfam; PF03878; YIF1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW Membrane; Phosphoprotein; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:21406692"
FT CHAIN 2..293
FT /note="Protein YIF1A"
FT /id="PRO_0000233275"
FT TOPO_DOM 2..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..174
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 204..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..229
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 230..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT CONFLICT 144
FT /note="M -> K (in Ref. 2; CAG32991 and 4; AAH01299/
FT AAH09892)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 293 AA; 32011 MW; AFD61379A56085EA CRC64;
MAYHSGYGAH GSKHRARAAP DPPPLFDDTS GGYSSQPGGY PATGADVAFS VNHLLGDPMA
NVAMAYGSSI ASHGKDMVHK ELHRFVSVSK LKYFFAVDTA YVAKKLGLLV FPYTHQNWEV
QYSRDAPLPP RQDLNAPDLY IPTMAFITYV LLAGMALGIQ KRFSPEVLGL CASTALVWVV
MEVLALLLGL YLATVRSDLS TFHLLAYSGY KYVGMILSVL TGLLFGSDGY YVALAWTSSA
LMYFIVRSLR TAALGPDSMG GPVPRQRLQL YLTLGAAAFQ PLIIYWLTFH LVR
