YIF1A_MOUSE
ID YIF1A_MOUSE Reviewed; 293 AA.
AC Q91XB7; Q9CWB2;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Protein YIF1A;
DE AltName: Full=YIP1-interacting factor homolog A;
GN Name=Yif1a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Kidney, Lung, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Possible role in transport between endoplasmic reticulum and
CC Golgi. {ECO:0000250|UniProtKB:O95070}.
CC -!- SUBUNIT: Interacts with YIPF5. {ECO:0000250|UniProtKB:O95070}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:O95070}; Multi-pass membrane protein
CC {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O95070};
CC Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000250|UniProtKB:O95070};
CC Multi-pass membrane protein {ECO:0000255}. Note=Cycles between the
CC endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate
CC compartment. {ECO:0000250|UniProtKB:O95070}.
CC -!- SIMILARITY: Belongs to the YIF1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB21972.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK002259; BAB21972.2; ALT_INIT; mRNA.
DR EMBL; AK077329; BAC36754.1; -; mRNA.
DR EMBL; AK160409; BAE35776.1; -; mRNA.
DR EMBL; BC011117; AAH11117.1; -; mRNA.
DR CCDS; CCDS29450.1; -.
DR RefSeq; NP_080829.1; NM_026553.4.
DR AlphaFoldDB; Q91XB7; -.
DR BioGRID; 212650; 3.
DR IntAct; Q91XB7; 2.
DR MINT; Q91XB7; -.
DR STRING; 10090.ENSMUSP00000025811; -.
DR iPTMnet; Q91XB7; -.
DR PhosphoSitePlus; Q91XB7; -.
DR EPD; Q91XB7; -.
DR MaxQB; Q91XB7; -.
DR PaxDb; Q91XB7; -.
DR PeptideAtlas; Q91XB7; -.
DR PRIDE; Q91XB7; -.
DR ProteomicsDB; 275330; -.
DR Antibodypedia; 3107; 41 antibodies from 14 providers.
DR DNASU; 68090; -.
DR Ensembl; ENSMUST00000025811; ENSMUSP00000025811; ENSMUSG00000024875.
DR GeneID; 68090; -.
DR KEGG; mmu:68090; -.
DR UCSC; uc008gcd.2; mouse.
DR CTD; 10897; -.
DR MGI; MGI:1915340; Yif1a.
DR VEuPathDB; HostDB:ENSMUSG00000024875; -.
DR eggNOG; KOG3094; Eukaryota.
DR GeneTree; ENSGT00390000009423; -.
DR HOGENOM; CLU_047877_1_1_1; -.
DR InParanoid; Q91XB7; -.
DR OMA; SHYFQVS; -.
DR OrthoDB; 1256839at2759; -.
DR PhylomeDB; Q91XB7; -.
DR TreeFam; TF314528; -.
DR BioGRID-ORCS; 68090; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Yif1a; mouse.
DR PRO; PR:Q91XB7; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q91XB7; protein.
DR Bgee; ENSMUSG00000024875; Expressed in internal carotid artery and 257 other tissues.
DR ExpressionAtlas; Q91XB7; baseline and differential.
DR Genevisible; Q91XB7; MM.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISO:MGI.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR005578; Yif1_fam.
DR PANTHER; PTHR14083; PTHR14083; 1.
DR Pfam; PF03878; YIF1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW Membrane; Phosphoprotein; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O95070"
FT CHAIN 2..293
FT /note="Protein YIF1A"
FT /id="PRO_0000233276"
FT TOPO_DOM 2..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..174
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 204..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..229
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 230..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:O95070"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O95070"
SQ SEQUENCE 293 AA; 32134 MW; C8FB798A9A235577 CRC64;
MAYHSAYGVH GSKHRTRAAP DPPPLFDDTS GGYSSQLGGY PAPGADVAFS VNNLLGDPVA
NMAMAYGTSI ASQGKDIVHK ELHRFVSVNK LKYFFAVDTA YVAKKLGLLV FPYTHQNWKM
QYSHDVPLPP RKDLNAPDLY IPTMAFITYV LLAGMALGIQ QRFSPEVLGL CASTALVWVF
MEVLALLLGL YLATVRSELS TFHLLAYSGY KYVGMILSVL TGLLFGSDGY YVALAWTSSA
LMYFIVRSLR TAASGPDSMG GPAPRQRLQL YLTLGAAAFQ PLIIYWLTFH LVR
