ID   YIF1B_DANRE             Reviewed;         304 AA.
AC   Q5U3G6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein YIF1B;
DE   AltName: Full=YIP1-interacting factor homolog B;
GN   Name=yif1b; ORFNames=zgc:103562;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions in endoplasmic reticulum to Golgi vesicle-mediated
CC       transport and regulates the proper organization of the endoplasmic
CC       reticulum and the Golgi (By similarity). Plays a key role in targeting
CC       to neuronal dendrites receptors such as HTR1A (By similarity). Plays
CC       also a role in primary cilium and sperm flagellum assembly probably
CC       through protein transport to these compartments (By similarity).
CC       {ECO:0000250|UniProtKB:Q6PEC3, ECO:0000250|UniProtKB:Q9CX30}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q5BJH7}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5BJH7};
CC       Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000250|UniProtKB:Q5BJH7};
CC       Multi-pass membrane protein {ECO:0000255}. Note=Shuttles between the
CC       endoplasmic reticulum, the intermediate compartment and the Golgi
CC       apparatus. {ECO:0000250|UniProtKB:Q5BJH7}.
CC   -!- SIMILARITY: Belongs to the YIF1 family. {ECO:0000305}.
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DR   EMBL; BC085552; AAH85552.2; -; mRNA.
DR   RefSeq; NP_001007335.2; NM_001007334.1.
DR   AlphaFoldDB; Q5U3G6; -.
DR   STRING; 7955.ENSDARP00000059284; -.
DR   PaxDb; Q5U3G6; -.
DR   GeneID; 492462; -.
DR   KEGG; dre:492462; -.
DR   CTD; 90522; -.
DR   ZFIN; ZDB-GENE-041114-16; yif1b.
DR   eggNOG; KOG3094; Eukaryota.
DR   InParanoid; Q5U3G6; -.
DR   OrthoDB; 1256839at2759; -.
DR   PhylomeDB; Q5U3G6; -.
DR   PRO; PR:Q5U3G6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0120316; P:sperm flagellum assembly; ISS:UniProtKB.
DR   InterPro; IPR005578; Yif1_fam.
DR   PANTHER; PTHR14083; PTHR14083; 1.
DR   Pfam; PF03878; YIF1; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..304
FT                   /note="Protein YIF1B"
FT                   /id="PRO_0000307261"
FT   TOPO_DOM        1..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..182
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..212
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..236
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..282
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        304
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          21..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   304 AA;  34029 MW;  80D23F2CDD54D19E CRC64;
     MMEYPNQSGF RQRKLLPQVR MRGSAMEPSD PTQLFDDTSS GVNKHEPGRV GKSPDVFSGQ
     NLLSDPMSNL AMAYGSSLAS HGKEMMDKNL DRFIPISKLK YYFAVDTVYV GKKLGLLVFP
     YMHDNWEVNY QQDTPVAPRF DINAPDLYIP VMGFITYVLV AGLALGTQNR FSPEILGIQA
     SSALVWLIIE VLAVLLSLYL VTVNTDLTTI DLVAFSGYKY VGMIVGVVAG LLFGRTGYYL
     ALLWFCASIF VFTIRTLRLK ILSEAAAEGR LVRGTKNQLR MYLTMAIAAA QPVFMYWLTF
     HLVR