YIF1B_RAT
ID YIF1B_RAT Reviewed; 259 AA.
AC Q6PEC3;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Protein YIF1B;
DE AltName: Full=YIP1-interacting factor homolog B;
GN Name=Yif1b {ECO:0000312|RGD:735199};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-126 (ISOFORM 1).
RG Amgen EST program;
RT "Amgen rat EST program.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP TISSUE SPECIFICITY, INTERACTION WITH HTR1A, SUBCELLULAR LOCATION, AND
RP FUNCTION.
RX PubMed=18685031; DOI=10.1523/jneurosci.4487-07.2008;
RA Carrel D., Masson J., Al Awabdh S., Capra C.B., Lenkei Z., Hamon M.,
RA Emerit M.B., Darmon M.;
RT "Targeting of the 5-HT1A serotonin receptor to neuronal dendrites is
RT mediated by Yif1B.";
RL J. Neurosci. 28:8063-8073(2008).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=26077767; DOI=10.1111/tra.12306;
RA Alterio J., Masson J., Diaz J., Chachlaki K., Salman H., Areias J.,
RA Al Awabdh S., Emerit M.B., Darmon M.;
RT "Yif1B Is Involved in the Anterograde Traffic Pathway and the Golgi
RT Architecture.";
RL Traffic 16:978-993(2015).
CC -!- FUNCTION: Functions in endoplasmic reticulum to Golgi vesicle-mediated
CC transport and regulates the proper organization of the endoplasmic
CC reticulum and the Golgi (By similarity). Plays a key role in targeting
CC to neuronal dendrites receptors such as HTR1A (PubMed:18685031). Plays
CC also a role in primary cilium and sperm flagellum assembly probably
CC through protein transport to these compartments (By similarity).
CC {ECO:0000250|UniProtKB:Q9CX30, ECO:0000269|PubMed:18685031}.
CC -!- SUBUNIT: Interacts with HTR1A (via C-terminus) (PubMed:18685031).
CC Interacts with ABCB9 (via TMD0); this interaction allows (but is not
CC essential) the ER-to-Golgi trafficking and strongly depends on a salt
CC bridge within TMD0 (By similarity). {ECO:0000250|UniProtKB:Q5BJH7,
CC ECO:0000269|PubMed:18685031}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:26077767}; Multi-pass membrane protein
CC {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:26077767};
CC Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000269|PubMed:18685031,
CC ECO:0000269|PubMed:26077767}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Shuttles between the endoplasmic reticulum, the
CC intermediate compartment and the Golgi apparatus.
CC {ECO:0000269|PubMed:26077767}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PEC3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PEC3-2; Sequence=VSP_028657;
CC -!- TISSUE SPECIFICITY: Highly expressed in brain. Expressed in heart,
CC kidney, and lung and lower levels in spleen, muscle, and intestine (at
CC protein level) (PubMed:18685031). Expressed in serotoninergic neurons
CC (at protein level) (PubMed:18685031). {ECO:0000269|PubMed:18685031}.
CC -!- SIMILARITY: Belongs to the YIF1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH58153.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC058153; AAH58153.1; ALT_INIT; mRNA.
DR EMBL; CB797587; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001014810.1; NM_001014810.1.
DR RefSeq; NP_942029.2; NM_198734.2.
DR AlphaFoldDB; Q6PEC3; -.
DR IntAct; Q6PEC3; 2.
DR MINT; Q6PEC3; -.
DR PRIDE; Q6PEC3; -.
DR Ensembl; ENSRNOT00000044145; ENSRNOP00000045414; ENSRNOG00000055286. [Q6PEC3-1]
DR GeneID; 292768; -.
DR KEGG; rno:292768; -.
DR UCSC; RGD:735199; rat. [Q6PEC3-1]
DR CTD; 90522; -.
DR RGD; 735199; Yif1b.
DR GeneTree; ENSGT00390000009423; -.
DR HOGENOM; CLU_047877_1_1_1; -.
DR InParanoid; Q6PEC3; -.
DR OrthoDB; 1256839at2759; -.
DR PhylomeDB; Q6PEC3; -.
DR PRO; PR:Q6PEC3; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000020616; Expressed in thymus and 19 other tissues.
DR ExpressionAtlas; Q6PEC3; baseline.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; ISO:RGD.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0006612; P:protein targeting to membrane; ISS:UniProtKB.
DR GO; GO:0120316; P:sperm flagellum assembly; ISS:UniProtKB.
DR InterPro; IPR005578; Yif1_fam.
DR PANTHER; PTHR14083; PTHR14083; 2.
DR Pfam; PF03878; YIF1; 2.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Endoplasmic reticulum; Golgi apparatus;
KW Membrane; Phosphoprotein; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..259
FT /note="Protein YIF1B"
FT /id="PRO_0000307260"
FT TOPO_DOM 9..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..186
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9CX30"
FT MOD_RES 12
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9CX30"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5BJH7"
FT VAR_SEQ 1..19
FT /note="MHATGLAAPAGTPRLRKWP -> MPRPGRGRIAA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028657"
SQ SEQUENCE 259 AA; 28418 MW; C918AA2E90B9B204 CRC64;
MHATGLAAPA GTPRLRKWPS KRRVPVSQPG MADPHQFFDD TSSAPSRGYG GQPSPGSLGY
PTSSSEAAFL AAPMSNMAMA YGSSLAAQGK ELVDKNIDRF IPVSKLKYYF AVDTVYVGKK
LGLLVFPYLH QDWEVQYQQD TPVAPRFDIN APDLYIPAMA FITYILVAGL ALGTQDRMIG
GVLTGLLFGK IGYYLVLAWC CVSIFVFMIR TLRLKILAQA AAEGVPVRGA RNQLRMYLTM
AVAAAQPVLM YWLTFHLVR
