YIF1_SCHPO
ID YIF1_SCHPO Reviewed; 293 AA.
AC P87148;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein transport protein yif1;
DE AltName: Full=Heavy metal resistance factor 1;
DE AltName: Full=YIP1-interacting factor 1;
GN Name=hrf1 {ECO:0000312|PomBase:SPBC25H2.06c};
GN Synonyms=yif1 {ECO:0000250|UniProtKB:P53845}; ORFNames=SPBC25H2.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for fusion of ER-derived vesicles with the Golgi
CC during ER-to-Golgi protein transport. May be involved in proper
CC membrane localization of Rab GTPases (By similarity).
CC {ECO:0000250|UniProtKB:P53845}.
CC -!- SUBUNIT: Component of the yip1-yif1 complex, composed of at least yif1,
CC yip1 and yos1. The complex interacts with the ER to Golgi SNAREs bos1
CC and sec22 (By similarity). {ECO:0000250|UniProtKB:P53845}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P53845}; Multi-pass membrane protein
CC {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P53845};
CC Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-
CC coated vesicle {ECO:0000250|UniProtKB:P53845}.
CC -!- SIMILARITY: Belongs to the YIF1 family. {ECO:0000255}.
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DR EMBL; CU329671; CAB08782.1; -; Genomic_DNA.
DR PIR; T40001; T40001.
DR RefSeq; NP_596360.1; NM_001022281.2.
DR AlphaFoldDB; P87148; -.
DR BioGRID; 276885; 3.
DR STRING; 4896.SPBC25H2.06c.1; -.
DR iPTMnet; P87148; -.
DR MaxQB; P87148; -.
DR PaxDb; P87148; -.
DR PRIDE; P87148; -.
DR EnsemblFungi; SPBC25H2.06c.1; SPBC25H2.06c.1:pep; SPBC25H2.06c.
DR GeneID; 2540356; -.
DR KEGG; spo:SPBC25H2.06c; -.
DR PomBase; SPBC25H2.06c; hrf1.
DR VEuPathDB; FungiDB:SPBC25H2.06c; -.
DR eggNOG; KOG3094; Eukaryota.
DR HOGENOM; CLU_047877_2_0_1; -.
DR InParanoid; P87148; -.
DR OMA; FMWLLTR; -.
DR PhylomeDB; P87148; -.
DR PRO; PR:P87148; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; ISO:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:PomBase.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; ISO:PomBase.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISO:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; NAS:PomBase.
DR InterPro; IPR005578; Yif1_fam.
DR PANTHER; PTHR14083; PTHR14083; 1.
DR Pfam; PF03878; YIF1; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..293
FT /note="Protein transport protein yif1"
FT /id="PRO_0000253961"
FT TOPO_DOM 1..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..175
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..226
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 293 AA; 33045 MW; 93A4A51E78C87CEA CRC64;
MPPKLYHPQP THAIPVSNMR VNTRYEPTAG FSGTSVPSVQ AANPSAYLPN SATAQMGFQL
GKNAVNAGQE YVEQNFGKWL STTRLHHYFT VTNSYVVAKL LLIIFPWRRR SWARKLRRSE
INGSAEGYCP PAEDLNSPDM YIPLMAFTTH ILLLCALAGL QDDFQPELFG LRASKACAVV
LVEFLATRLG CYLLNISSQS QVLDLLAFSG YKFVGLILTS LSKLFEMPWV TRFVFLYMYL
ATAFFLLRSL KYAVLPESTM AINATITSHQ RSRRIYFLFF IAASQILFMY VLS
