YIFK_ECOLI
ID YIFK_ECOLI Reviewed; 461 AA.
AC P27837; P76756; Q2M8A4; Q6BEZ8;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 4.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Probable transport protein YifK;
GN Name=yifK; OrderedLocusNames=b3795, JW5595;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=1379743; DOI=10.1126/science.1379743;
RA Daniels D.L., Plunkett G. III, Burland V.D., Blattner F.R.;
RT "Analysis of the Escherichia coli genome: DNA sequence of the region from
RT 84.5 to 86.5 minutes.";
RL Science 257:771-778(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO 68
RP AND 74-75.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP SEQUENCE REVISION TO 68 AND 346-349.
RX PubMed=16397293; DOI=10.1093/nar/gkj405;
RA Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R.,
RA Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T.,
RA Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H.,
RA Thomson N.R., Wishart D., Wanner B.L.;
RT "Escherichia coli K-12: a cooperatively developed annotation snapshot
RT -- 2005.";
RL Nucleic Acids Res. 34:1-9(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Probable amino-acid or metabolite transport protein.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M87049; AAA67595.1; -; Genomic_DNA.
DR EMBL; U00096; AAT48216.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77502.1; -; Genomic_DNA.
DR PIR; H65183; H65183.
DR RefSeq; WP_000774731.1; NZ_STEB01000021.1.
DR RefSeq; YP_026258.1; NC_000913.3.
DR AlphaFoldDB; P27837; -.
DR SMR; P27837; -.
DR BioGRID; 4261339; 151.
DR STRING; 511145.b3795; -.
DR TCDB; 2.A.3.1.15; the amino acid-polyamine-organocation (apc) family.
DR PaxDb; P27837; -.
DR PRIDE; P27837; -.
DR EnsemblBacteria; AAT48216; AAT48216; b3795.
DR EnsemblBacteria; BAE77502; BAE77502; BAE77502.
DR GeneID; 66672301; -.
DR GeneID; 945400; -.
DR KEGG; ecj:JW5595; -.
DR KEGG; eco:b3795; -.
DR PATRIC; fig|1411691.4.peg.2910; -.
DR EchoBASE; EB1428; -.
DR eggNOG; COG1113; Bacteria.
DR HOGENOM; CLU_007946_9_3_6; -.
DR InParanoid; P27837; -.
DR OMA; CIAYMNV; -.
DR PhylomeDB; P27837; -.
DR BioCyc; EcoCyc:YIFK-MON; -.
DR PRO; PR:P27837; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004840; Amoino_acid_permease_CS.
DR Pfam; PF00324; AA_permease; 1.
DR PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..461
FT /note="Probable transport protein YifK"
FT /id="PRO_0000054218"
FT TOPO_DOM 1..16
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..39
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..96
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..122
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..200
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..277
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..332
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 354..359
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 381..400
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 422..429
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 451..461
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 74..75
FT /note="GS -> VA (in Ref. 1; AAA67595)"
FT /evidence="ECO:0000305"
FT CONFLICT 346..349
FT /note="GSCL -> AHAW (in Ref. 1; AAA67595)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 461 AA; 50399 MW; 62EE13158BC8EE3A CRC64;
MADNKPELQR GLEARHIELI ALGGTIGVGL FMGAASTLKW AGPSVLLAYI IAGLFVFFIM
RSMGEMLFLE PVTGSFAVYA HRYMSPFFGY LTAWSYWFMW MAVGISEITA IGVYVQFWFP
EMAQWIPALI AVALVALANL AAVRLYGEIE FWFAMIKVTT IIVMIVIGLG VIFFGFGNGG
QSIGFSNLTE HGGFFAGGWK GFLTALCIVV ASYQGVELIG ITAGEAKNPQ VTLRSAVGKV
LWRILIFYVG AIFVIVTIFP WNEIGSNGSP FVLTFAKIGI TAAAGIINFV VLTAALSGCN
SGMYSCGRML YALAKNRQLP AAMAKVSRHG VPVAGVAVSI AILLIGSCLN YIIPNPQRVF
VYVYSASVLP GMVPWFVILI SQLRFRRAHK AAIASHPFRS ILFPWANYVT MAFLICVLIG
MYFNEDTRMS LFVGIIFMLA VTAIYKVFGL NRHGKAHKLE E
