ID   CBID_SALTY              Reviewed;         379 AA.
AC   Q05628;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Cobalt-precorrin-5B C(1)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_00787};
DE            EC=2.1.1.195 {ECO:0000255|HAMAP-Rule:MF_00787};
DE   AltName: Full=Cobalt-precorrin-6A synthase {ECO:0000255|HAMAP-Rule:MF_00787};
GN   Name=cbiD {ECO:0000255|HAMAP-Rule:MF_00787}; OrderedLocusNames=STM2032;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=8501034; DOI=10.1128/jb.175.11.3303-3316.1993;
RA   Roth J.R., Lawrence J.G., Rubenfield M., Kieffer-Higgins S., Church G.M.;
RT   "Characterization of the cobalamin (vitamin B12) biosynthetic genes of
RT   Salmonella typhimurium.";
RL   J. Bacteriol. 175:3303-3316(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [3]
RP   FUNCTION.
RX   PubMed=15741157; DOI=10.1074/jbc.m501805200;
RA   Roessner C.A., Williams H.J., Scott A.I.;
RT   "Genetically engineered production of 1-desmethylcobyrinic acid, 1-
RT   desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in
RT   Escherichia coli implies a role for CbiD in C-1 methylation in the
RT   anaerobic pathway to cobalamin.";
RL   J. Biol. Chem. 280:16748-16753(2005).
CC   -!- FUNCTION: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to
CC       form cobalt-precorrin-6A. {ECO:0000255|HAMAP-Rule:MF_00787,
CC       ECO:0000269|PubMed:15741157}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A +
CC         S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:26285, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:60063, ChEBI:CHEBI:60064;
CC         EC=2.1.1.195; Evidence={ECO:0000255|HAMAP-Rule:MF_00787};
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 6/10. {ECO:0000255|HAMAP-Rule:MF_00787}.
CC   -!- SIMILARITY: Belongs to the CbiD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00787}.
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DR   EMBL; L12006; AAA27255.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20936.1; -; Genomic_DNA.
DR   RefSeq; NP_460977.1; NC_003197.2.
DR   RefSeq; WP_001292908.1; NC_003197.2.
DR   AlphaFoldDB; Q05628; -.
DR   SMR; Q05628; -.
DR   STRING; 99287.STM2032; -.
DR   PaxDb; Q05628; -.
DR   EnsemblBacteria; AAL20936; AAL20936; STM2032.
DR   GeneID; 1253553; -.
DR   KEGG; stm:STM2032; -.
DR   PATRIC; fig|99287.12.peg.2154; -.
DR   HOGENOM; CLU_041273_1_0_6; -.
DR   OMA; YHGKLIK; -.
DR   PhylomeDB; Q05628; -.
DR   BioCyc; MetaCyc:MON-13221; -.
DR   BioCyc; SENT99287:STM2032-MON; -.
DR   BRENDA; 2.1.1.195; 2169.
DR   UniPathway; UPA00148; UER00227.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0043780; F:cobalt-precorrin-5B C1-methyltransferase activity; IEA:RHEA.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0046140; P:corrin biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2110.10; -; 1.
DR   HAMAP; MF_00787; CbiD; 1.
DR   InterPro; IPR002748; CbiD.
DR   InterPro; IPR036074; CbiD_sf.
DR   PANTHER; PTHR35863; PTHR35863; 1.
DR   Pfam; PF01888; CbiD; 1.
DR   PIRSF; PIRSF026782; CbiD; 1.
DR   SUPFAM; SSF111342; SSF111342; 1.
DR   TIGRFAMs; TIGR00312; cbiD; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis; Methyltransferase; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..379
FT                   /note="Cobalt-precorrin-5B C(1)-methyltransferase"
FT                   /id="PRO_0000141684"
SQ   SEQUENCE   379 AA;  40800 MW;  3A4CDA8230CB22D4 CRC64;
     MSELSFDAPV WHHGKALRKG YTTGSCATAA AKVAALMVLR QHLIHQVSIV TPSGVTLCLN
     VESPHIEGQQ AIAAIRKDGG DDVDATHGML IFARVTLNDS GEITLTGGEG IGTVTRKGIG
     LPLGSAAINR TPRHTIESAV REAIGPARGA DVEIFAPEGE ARAQKTYNSR LGILGGISII
     GTTGIVTPMS EESWKRSLSL ELEIKRASGL TRVILVPGNH GERFVREQMG VDTQAVVTMS
     NFVGYMIEEA VRLGFCQIVL VGHPGKLIKI AAGIFHTHSH IADARMETLV AHLALLGAPL
     ELLTLVSDCD TTEAAMEHIE AYGFGHIYNH LARRICLRVM QMLRFTKTPP VCDAILFSFD
     NHILGSNRPV DEIAKELQC