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YIHN_ECOLI
ID   YIHN_ECOLI              Reviewed;         421 AA.
AC   P32135; Q2M8H1;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Inner membrane protein YihN {ECO:0000305};
GN   Name=yihN; OrderedLocusNames=b3874, JW3845;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8346018; DOI=10.1093/nar/21.15.3391;
RA   Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome. III. DNA sequence of the region
RT   from 87.2 to 89.2 minutes.";
RL   Nucleic Acids Res. 21:3391-3398(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   TOPOLOGY [LARGE SCALE ANALYSIS], AND SUBCELLULAR LOCATION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
RN   [5]
RP   INDUCTION.
RC   STRAIN=K12 / BW25113;
RX   PubMed=25346166; DOI=10.1080/09168451.2014.972328;
RA   Yamamoto K., Nonaka G., Ozawa T., Takumi K., Ishihama A.;
RT   "Induction of the Escherichia coli yijE gene expression by cystine.";
RL   Biosci. Biotechnol. Biochem. 79:218-222(2015).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- INDUCTION: Down-regulated by cystine. {ECO:0000269|PubMed:25346166}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; L19201; AAB03008.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76871.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77435.1; -; Genomic_DNA.
DR   PIR; S40819; S40819.
DR   RefSeq; NP_418310.1; NC_000913.3.
DR   RefSeq; WP_000956313.1; NZ_SSZK01000026.1.
DR   AlphaFoldDB; P32135; -.
DR   SMR; P32135; -.
DR   BioGRID; 4262634; 192.
DR   DIP; DIP-12495N; -.
DR   IntAct; P32135; 1.
DR   STRING; 511145.b3874; -.
DR   TCDB; 2.A.1.52.1; the major facilitator superfamily (mfs).
DR   PaxDb; P32135; -.
DR   PRIDE; P32135; -.
DR   EnsemblBacteria; AAC76871; AAC76871; b3874.
DR   EnsemblBacteria; BAE77435; BAE77435; BAE77435.
DR   GeneID; 948365; -.
DR   KEGG; ecj:JW3845; -.
DR   KEGG; eco:b3874; -.
DR   PATRIC; fig|1411691.4.peg.2837; -.
DR   EchoBASE; EB1786; -.
DR   eggNOG; COG2271; Bacteria.
DR   HOGENOM; CLU_043790_0_0_6; -.
DR   OMA; IAAPYYL; -.
DR   PhylomeDB; P32135; -.
DR   BioCyc; EcoCyc:YIHN-MON; -.
DR   PRO; PR:P32135; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031224; C:intrinsic component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..421
FT                   /note="Inner membrane protein YihN"
FT                   /id="PRO_0000169676"
FT   TOPO_DOM        1..44
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..73
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        74..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        92..95
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        96..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..220
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        263..288
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        331..354
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        376..385
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        407..421
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000269|PubMed:15919996"
SQ   SEQUENCE   421 AA;  46335 MW;  4FD9FAAA33A8E846 CRC64;
     MLTKKKWALF SLLTLCGGTI YKLPSLKDAF YIPMQEYFHL TNGQIGNAMS VNSFVTTVGF
     FLSIYFADKL PRRYTMSFSL IATGLLGVYL TTMPGYWGIL FVWALFGVTC DMMNWPVLLK
     SVSRLGNSEQ QGRLFGFFET GRGIVDTVVA FSALAVFTWF GSGLLGFKAG IWFYSLIVIA
     VGIIIFFVLN DKEEAPSVEV KKEDGASKNT SMTSVLKDKT IWLIAFNVFF VYAVYCGLTF
     FIPFLKNIYL LPVALVGAYG IINQYCLKMI GGPIGGMISD KILKSPSKYL CYTFIISTAA
     LVLLIMLPHE SMPVYLGMAC TLGFGAIVFT QRAVFFAPIG EAKIAENKTG AAMALGSFIG
     YAPAMFCFSL YGYILDLNPG IIGYKIVFGI MACFAFSGAV VSVMLVKRIS QRKKEMLAAE
     A
 
 
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