YIHP_SALTY
ID YIHP_SALTY Reviewed; 460 AA.
AC Q9L7R5;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Putative 2,3-dihydroxypropane-1-sulfonate exporter;
GN Name=yihP; OrderedLocusNames=STM4018;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RA Krogan N.J., Zhang R., Neuhard J., Kelln R.A.;
RT "Utilization of dihydroorotate as sole pyrimidine source by Salmonella
RT typhimurium.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Could be involved in the export of 2,3-dihydroxypropane-1-
CC sulfonate (DHPS). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the sodium:galactoside symporter (TC 2.A.2)
CC family. {ECO:0000305}.
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DR EMBL; AF220438; AAF27926.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL22857.1; -; Genomic_DNA.
DR RefSeq; NP_462898.1; NC_003197.2.
DR RefSeq; WP_000084251.1; NC_003197.2.
DR AlphaFoldDB; Q9L7R5; -.
DR SMR; Q9L7R5; -.
DR STRING; 99287.STM4018; -.
DR PaxDb; Q9L7R5; -.
DR EnsemblBacteria; AAL22857; AAL22857; STM4018.
DR GeneID; 1255544; -.
DR KEGG; stm:STM4018; -.
DR PATRIC; fig|99287.12.peg.4233; -.
DR HOGENOM; CLU_027408_0_1_6; -.
DR OMA; AYGMGDL; -.
DR PhylomeDB; Q9L7R5; -.
DR BioCyc; SENT99287:STM4018-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008643; P:carbohydrate transport; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR039672; MFS_2.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001927; Na/Gal_symport.
DR InterPro; IPR018043; Na/Gal_symport_CS.
DR PANTHER; PTHR11328; PTHR11328; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00792; gph; 1.
DR PROSITE; PS00872; NA_GALACTOSIDE_SYMP; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..460
FT /note="Putative 2,3-dihydroxypropane-1-sulfonate exporter"
FT /id="PRO_0000170770"
FT TOPO_DOM 1..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..46
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..91
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..122
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..190
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..275
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 351..386
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 408..418
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 440..460
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 460 AA; 50633 MW; 9DE5A0D4B892DF7E CRC64;
MSQTSSNPAT LRLPFKEKLA YGLGDLGSNI LLDIGTLYLL KFYTDVLGLP GTYGGIIFLI
AKFFTAFTDM GTGIMLDSRR KIGPKGKFRP FVLYAAFPVT LLAIANFVGT PFEVTGKTVV
ATMLFMLYGL VFSMMNCSYG AMVPAITKNP DERASLAAWR QGGATLGLLL CTVGFVPVMN
LIEGNAQLSY IFAATLFSLF GLLFMWLCYA GVKERYVEVK PVDSAQKPGL LQSFRAIAGN
RPLFILCIAN LCTLGAFNVK LAIQVYYTQY VLNDPILLSW MGFFSMGCIF IGVFLMPGAV
RRFGKKKVYI GGLLIWVAGD LLNYFFGGGS VSFVAFSCLA FFGSAFVNSL NWALVSDTVE
YGEWRTGVRS EGTVYTGFTF FRKVSQALAG FFPGWMLTQI GYIPNVVQSA GTVEGLRQLI
FIYPCVLAVI TIIAMGCFYN LNEKMYVRIV EEIEARKHTV
