YIJE_ECOLI
ID YIJE_ECOLI Reviewed; 301 AA.
AC P0ABT8; P32667; Q2M8N9;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Probable cystine transporter YijE {ECO:0000305};
GN Name=yijE; OrderedLocusNames=b3943, JW5557;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8265357; DOI=10.1093/nar/21.23.5408;
RA Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.;
RT "Analysis of the Escherichia coli genome. IV. DNA sequence of the region
RT from 89.2 to 92.8 minutes.";
RL Nucleic Acids Res. 21:5408-5417(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS], AND SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [5]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=K12 / BW25113;
RX PubMed=25346166; DOI=10.1080/09168451.2014.972328;
RA Yamamoto K., Nonaka G., Ozawa T., Takumi K., Ishihama A.;
RT "Induction of the Escherichia coli yijE gene expression by cystine.";
RL Biosci. Biotechnol. Biochem. 79:218-222(2015).
CC -!- FUNCTION: Involved in response to cystine. Overexpression confers
CC tolerance to excess cystine. {ECO:0000269|PubMed:25346166}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- INDUCTION: Up-regulated by cystine. {ECO:0000269|PubMed:25346166}.
CC -!- DISRUPTION PHENOTYPE: Deletion increases the sensitivity to cystine.
CC {ECO:0000269|PubMed:25346166}.
CC -!- SIMILARITY: Belongs to the EamA transporter family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC43049.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U00006; AAC43049.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC76925.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE77367.1; -; Genomic_DNA.
DR PIR; I78664; I78664.
DR RefSeq; NP_418378.4; NC_000913.3.
DR RefSeq; WP_001271242.1; NZ_SSZK01000014.1.
DR AlphaFoldDB; P0ABT8; -.
DR SMR; P0ABT8; -.
DR BioGRID; 4261103; 89.
DR STRING; 511145.b3943; -.
DR PaxDb; P0ABT8; -.
DR PRIDE; P0ABT8; -.
DR EnsemblBacteria; AAC76925; AAC76925; b3943.
DR EnsemblBacteria; BAE77367; BAE77367; BAE77367.
DR GeneID; 948445; -.
DR KEGG; ecj:JW5557; -.
DR KEGG; eco:b3943; -.
DR PATRIC; fig|1411691.4.peg.2761; -.
DR EchoBASE; EB1847; -.
DR eggNOG; COG0697; Bacteria.
DR HOGENOM; CLU_033863_5_0_6; -.
DR InParanoid; P0ABT8; -.
DR OMA; TLNMVYL; -.
DR PhylomeDB; P0ABT8; -.
DR BioCyc; EcoCyc:EG11902-MON; -.
DR BioCyc; MetaCyc:EG11902-MON; -.
DR PRO; PR:P0ABT8; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0000099; F:sulfur amino acid transmembrane transporter activity; IMP:EcoCyc.
DR GO; GO:0000101; P:sulfur amino acid transport; IEP:EcoCyc.
DR InterPro; IPR000620; EamA_dom.
DR Pfam; PF00892; EamA; 2.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..301
FT /note="Probable cystine transporter YijE"
FT /id="PRO_0000108175"
FT TOPO_DOM 1..8
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..38
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..98
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..150
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..185
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..218
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..268
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:15919996"
FT DOMAIN 13..141
FT /note="EamA 1"
FT /evidence="ECO:0000255"
FT DOMAIN 152..289
FT /note="EamA 2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 301 AA; 32866 MW; 1A822058FDA28696 CRC64;
MSAAGKSNPL AISGLVVLTL IWSYSWIFMK QVTSYIGAFD FTALRCIFGA LVLFIVLLLR
GRGMRPTPFK YTLAIALLQT CGMVGLAQWA LVSGGAGKVA ILSYTMPFWV VIFAALFLGE
RLRRGQYFAI LIAAFGLFLV LQPWQLDFSS MKSAMLAILS GVSWGASAIV AKRLYARHPR
VDLLSLTSWQ MLYAALVMSV VALLVPQREI DWQPTVFWAL AYSAILATAL AWSLWLFVLK
NLPASIASLS TLAVPVCGVL FSWWLLGENP GAVEGSGIVL IVLALALVSR KKKEAVSVKR
I
