ID   YIKA_SCHPO              Reviewed;         301 AA.
AC   Q8TFH4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Putative ribosomal RNA methyltransferase PB17E12.10c;
DE            EC=2.1.1.-;
DE   AltName: Full=rRNA (uridine-2'-O-)-methyltransferase;
GN   ORFNames=SPAPB17E12.10c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O-
CC         methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:54152, Rhea:RHEA-COMP:13812, Rhea:RHEA-COMP:13814,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65315, ChEBI:CHEBI:74478;
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase RlmE family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU329670; CAD27503.1; -; Genomic_DNA.
DR   RefSeq; NP_001018225.1; NM_001018705.2.
DR   AlphaFoldDB; Q8TFH4; -.
DR   BioGRID; 280511; 1.
DR   STRING; 4896.SPAPB17E12.10c.1; -.
DR   PaxDb; Q8TFH4; -.
DR   EnsemblFungi; SPAPB17E12.10c.1; SPAPB17E12.10c.1:pep; SPAPB17E12.10c.
DR   GeneID; 3361435; -.
DR   KEGG; spo:SPAPB17E12.10c; -.
DR   PomBase; SPAPB17E12.10c; -.
DR   VEuPathDB; FungiDB:SPAPB17E12.10c; -.
DR   eggNOG; KOG4589; Eukaryota.
DR   HOGENOM; CLU_921835_0_0_1; -.
DR   InParanoid; Q8TFH4; -.
DR   OMA; MVQGFEF; -.
DR   PhylomeDB; Q8TFH4; -.
DR   PRO; PR:Q8TFH4; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005739; C:mitochondrion; ISS:PomBase.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0008650; F:rRNA (uridine-2'-O-)-methyltransferase activity; ISS:PomBase.
DR   GO; GO:0000959; P:mitochondrial RNA metabolic process; IC:PomBase.
DR   GO; GO:0001510; P:RNA methylation; IBA:GO_Central.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF01728; FtsJ; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; rRNA processing;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..301
FT                   /note="Putative ribosomal RNA methyltransferase
FT                   PB17E12.10c"
FT                   /id="PRO_0000317209"
FT   ACT_SITE        247
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         87
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         89
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         107
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         186
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   301 AA;  34069 MW;  CD158F4937BDC6C2 CRC64;
     MSMRIWSRSS SAYSAIARSS SWFNNSLFSS CLLRFYSNPP KKTKKNTLIS LRKSAETANE
     KFIEKINKEH QLFKPGQIVV DLGCAPGIWS TIAARHVGLF GRVIACDIIP CRLPENSSMI
     QGNILSMEIQ LEIAKAAIRS RNSFFRNQQD HNSASIPYLQ SVFEEERDTK EKAKIEDLSA
     DVIMSDLGPP FPMVQGFEFW ISKLPYLAMQ TNEHLAVKDE LDSLYLAQAA LLFAIKALKP
     DGIFLCKVLE SSHLRSFAED LSMCFKCVKK IQFKTKIKDE LYAVYFCSGK QLSCHSKLLN
     I