YIL2_SCHPO
ID YIL2_SCHPO Reviewed; 374 AA.
AC Q9P3B1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Putative Rho GTPase-activating protein C1565.02c;
GN ORFNames=SPAC1565.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329670; CAB99269.1; -; Genomic_DNA.
DR RefSeq; NP_593281.1; NM_001018711.2.
DR PDB; 7E0W; X-ray; 2.80 A; A/B/C/D=2-156.
DR PDBsum; 7E0W; -.
DR AlphaFoldDB; Q9P3B1; -.
DR SMR; Q9P3B1; -.
DR STRING; 4896.SPAC1565.02c.1; -.
DR MaxQB; Q9P3B1; -.
DR PaxDb; Q9P3B1; -.
DR EnsemblFungi; SPAC1565.02c.1; SPAC1565.02c.1:pep; SPAC1565.02c.
DR GeneID; 2541571; -.
DR KEGG; spo:SPAC1565.02c; -.
DR PomBase; SPAC1565.02c; -.
DR VEuPathDB; FungiDB:SPAC1565.02c; -.
DR eggNOG; KOG4406; Eukaryota.
DR HOGENOM; CLU_738010_0_0_1; -.
DR InParanoid; Q9P3B1; -.
DR OMA; PFISIKF; -.
DR PhylomeDB; Q9P3B1; -.
DR Reactome; R-SPO-8980692; RHOA GTPase cycle.
DR Reactome; R-SPO-9013026; RHOB GTPase cycle.
DR Reactome; R-SPO-9013106; RHOC GTPase cycle.
DR Reactome; R-SPO-9013148; CDC42 GTPase cycle.
DR Reactome; R-SPO-9013405; RHOD GTPase cycle.
DR Reactome; R-SPO-9035034; RHOF GTPase cycle.
DR PRO; PR:Q9P3B1; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005938; C:cell cortex; IEA:UniProt.
DR GO; GO:0032153; C:cell division site; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0005096; F:GTPase activator activity; ISM:PomBase.
DR GO; GO:0120014; F:phospholipid transfer activity; ISM:PomBase.
DR GO; GO:0120010; P:intermembrane phospholipid transfer; ISM:PomBase.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 1.10.555.10; -; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Golgi apparatus; GTPase activation; Reference proteome.
FT CHAIN 1..374
FT /note="Putative Rho GTPase-activating protein C1565.02c"
FT /id="PRO_0000314093"
FT DOMAIN 170..352
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT HELIX 2..8
FT /evidence="ECO:0007829|PDB:7E0W"
FT STRAND 9..14
FT /evidence="ECO:0007829|PDB:7E0W"
FT STRAND 20..25
FT /evidence="ECO:0007829|PDB:7E0W"
FT HELIX 26..32
FT /evidence="ECO:0007829|PDB:7E0W"
FT HELIX 40..51
FT /evidence="ECO:0007829|PDB:7E0W"
FT STRAND 58..63
FT /evidence="ECO:0007829|PDB:7E0W"
FT HELIX 73..81
FT /evidence="ECO:0007829|PDB:7E0W"
FT HELIX 85..89
FT /evidence="ECO:0007829|PDB:7E0W"
FT STRAND 90..97
FT /evidence="ECO:0007829|PDB:7E0W"
FT HELIX 102..113
FT /evidence="ECO:0007829|PDB:7E0W"
FT HELIX 117..120
FT /evidence="ECO:0007829|PDB:7E0W"
FT STRAND 122..127
FT /evidence="ECO:0007829|PDB:7E0W"
FT HELIX 128..131
FT /evidence="ECO:0007829|PDB:7E0W"
FT TURN 132..134
FT /evidence="ECO:0007829|PDB:7E0W"
FT HELIX 137..139
FT /evidence="ECO:0007829|PDB:7E0W"
FT HELIX 144..146
FT /evidence="ECO:0007829|PDB:7E0W"
SQ SEQUENCE 374 AA; 43109 MW; F21DBA690457E2F5 CRC64;
MEHDLERLCF IGGYDNDNDK VIVVVTKNLE LFKKYDDINL IKEAYNHVHK LIQKDERYTA
VFFAHDSTVF SYLGLSLKAY YGMDYYLHKN VKAVYVIHTD WMSKVAIRTL LSIASPKFTR
KFRYLNSISD LNKYIPLSHL KLPPIVYEFD RNVEPAIFPS NPSATSNFIF PVQQWTRPPD
ALVEGMQVVS KSLQTEGLFR KSCSRKHLDI VIELYDNGCM VDLEAFGPIA ACSLIKHLFR
SLPSPLFSAE FLNGLTDHMD SGIDYAVSLQ KLIDASMDKN SQKLARLIFS LLYQITQHEQ
ENMMNAQNLA LCIGPSFSKA DNIAELMSMK DKEYNPYCYF LEYAILHWNT LFANEENWDS
YIPQDPTLLL PKTP
