YIM1_YEAST
ID YIM1_YEAST Reviewed; 365 AA.
AC P28625; D6VZX3;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 2.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Protein YIM1;
GN Name=YIM1; OrderedLocusNames=YMR152W; ORFNames=YM8520.01, YM9375.22;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1886606; DOI=10.1007/bf00282462;
RA Behrens M., Michaelis G., Pratje E.;
RT "Mitochondrial inner membrane protease 1 of Saccharomyces cerevisiae shows
RT sequence similarity to the Escherichia coli leader peptidase.";
RL Mol. Gen. Genet. 228:167-176(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=10515935; DOI=10.1128/jb.181.20.6441-6448.1999;
RA Athenstaedt K., Zweytick D., Jandrositz A., Kohlwein S.D., Daum G.;
RT "Identification and characterization of major lipid particle proteins of
RT the yeast Saccharomyces cerevisiae.";
RL J. Bacteriol. 181:6441-6448(1999).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=12077312; DOI=10.1073/pnas.132275199;
RA Birrell G.W., Brown J.A., Wu H.I., Giaever G., Chu A.M., Davis R.W.,
RA Brown J.M.;
RT "Transcriptional response of Saccharomyces cerevisiae to DNA-damaging
RT agents does not identify the genes that protect against these agents.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:8778-8783(2002).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
CC -!- SUBCELLULAR LOCATION: Lipid droplet. Mitochondrion.
CC -!- DISRUPTION PHENOTYPE: Displays sensitivity to DNA damaging agents.
CC {ECO:0000269|PubMed:12077312}.
CC -!- MISCELLANEOUS: Present with 6540 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the YIM1 family. {ECO:0000305}.
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DR EMBL; S55518; AAB19702.1; -; Genomic_DNA.
DR EMBL; Z47071; CAA87367.1; -; Genomic_DNA.
DR EMBL; Z49705; CAA89788.1; -; Genomic_DNA.
DR EMBL; AY558419; AAS56745.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA10047.1; -; Genomic_DNA.
DR PIR; S50409; S50409.
DR RefSeq; NP_013872.1; NM_001182654.1.
DR AlphaFoldDB; P28625; -.
DR SMR; P28625; -.
DR BioGRID; 35327; 59.
DR DIP; DIP-4467N; -.
DR IntAct; P28625; 3.
DR MINT; P28625; -.
DR STRING; 4932.YMR152W; -.
DR iPTMnet; P28625; -.
DR MaxQB; P28625; -.
DR PaxDb; P28625; -.
DR PRIDE; P28625; -.
DR EnsemblFungi; YMR152W_mRNA; YMR152W; YMR152W.
DR GeneID; 855183; -.
DR KEGG; sce:YMR152W; -.
DR SGD; S000004760; YIM1.
DR VEuPathDB; FungiDB:YMR152W; -.
DR eggNOG; KOG1198; Eukaryota.
DR GeneTree; ENSGT00880000138028; -.
DR HOGENOM; CLU_026673_3_3_1; -.
DR InParanoid; P28625; -.
DR OMA; GPLTYFT; -.
DR BioCyc; YEAST:G3O-32842-MON; -.
DR PRO; PR:P28625; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; P28625; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0005811; C:lipid droplet; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0018455; F:alcohol dehydrogenase [NAD(P)+] activity; IDA:SGD.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:SGD.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR SUPFAM; SSF50129; SSF50129; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Lipid droplet; Mitochondrion; Reference proteome.
FT CHAIN 1..365
FT /note="Protein YIM1"
FT /id="PRO_0000203310"
FT CONFLICT 121
FT /note="V -> I (in Ref. 1; AAB19702)"
FT /evidence="ECO:0000305"
FT CONFLICT 234
FT /note="S -> I (in Ref. 1; AAB19702)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="D -> N (in Ref. 1; AAB19702)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="L -> S (in Ref. 1; AAB19702)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 365 AA; 41637 MW; 88F6453D9E918A16 CRC64;
MSDEIVTNKS VTYVNNTTPV TITSSELDLR SCYQDDEVVI EVHAAALNPI DFITHQLCNS
YIFGKYPKTY SRDYSGVIIK AGKDVDNRWK VGDKVNGMYS HIYGERGTLT HYLILNPAKD
VPITHMVEVP KDENDPYDDF VYAAAWPLTF GTAFSTLYDF KKDWTSDSKV LVIGASTSVS
YAFVHIAKNY FNIGTVVGIC SKNSIERNKK LGYDYLVPYD EGSIVENVKK LKQSVLENDK
FDMIFDSVGN HDFFPVIDQF LKPKAKNSFY VTIAGNNKAD YKNISWRDFV SLSSILKAIN
PFKKYNWRFG HPYPPNNFIE VGNEMIKKGT YKPPIDSVYE FDQYKEAIDR LMSNRAKGKV
VVKMK
