YIP1_SCHPO
ID YIP1_SCHPO Reviewed; 227 AA.
AC O94348;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Protein transport protein yip1;
GN Name=yip1; ORFNames=SPCC61.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for fusion of ER-derived vesicles with the Golgi
CC during ER-to-Golgi protein transport, probably by mediating correct
CC membrane localization of ypt1. {ECO:0000250}.
CC -!- SUBUNIT: Component of the YIP1-YIF1 complex, composed of at least yif1,
CC yip1 and yos1. The complex interacts with the ER to Golgi SNAREs bos1
CC and sec22. Interacts with the prenylated form of the Rab GTPases ypt1
CC and ypt3 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA22273.1; -; Genomic_DNA.
DR PIR; T41464; T41464.
DR RefSeq; NP_588195.1; NM_001023185.2.
DR AlphaFoldDB; O94348; -.
DR BioGRID; 275648; 3.
DR STRING; 4896.SPCC61.04c.1; -.
DR MaxQB; O94348; -.
DR PaxDb; O94348; -.
DR EnsemblFungi; SPCC61.04c.1; SPCC61.04c.1:pep; SPCC61.04c.
DR GeneID; 2539076; -.
DR KEGG; spo:SPCC61.04c; -.
DR PomBase; SPCC61.04c; -.
DR VEuPathDB; FungiDB:SPCC61.04c; -.
DR eggNOG; KOG3103; Eukaryota.
DR HOGENOM; CLU_074741_4_2_1; -.
DR InParanoid; O94348; -.
DR OMA; IGINFDH; -.
DR PhylomeDB; O94348; -.
DR PRO; PR:O94348; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:PomBase.
DR GO; GO:0000139; C:Golgi membrane; ISO:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; ISM:PomBase.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISO:PomBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; ISO:PomBase.
DR InterPro; IPR045231; Yip1/4-like.
DR InterPro; IPR006977; Yip1_dom.
DR PANTHER; PTHR21236; PTHR21236; 1.
DR Pfam; PF04893; Yip1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..227
FT /note="Protein transport protein yip1"
FT /id="PRO_0000232732"
FT TOPO_DOM 1..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..178
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..205
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 227 AA; 25390 MW; B3D135FED3D4E232 CRC64;
MAYYNNPANL QYYDYSYTAD NSFNTQSRAA GFYDEPLHEP LSQGWLAAFS TSGYPGEPSL
LEELEINFGH IKQKTTHVLN PFKHVDVHIM DDTDMAGPIL FCLLFSTFLS LHGRSHFGYI
YGIALLGSLS LHFVLRLMSA KNLFFTRTVS VLGYSLLPLV VIAFFKNIFT FNGIAGYALA
ALACIWCTYA ASAMFVGILQ VNNMRFLVAY PIALFYGVFA VITVFSK
