YIP4_SCHPO
ID YIP4_SCHPO Reviewed; 225 AA.
AC Q9P6P8;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Protein YIP4;
DE AltName: Full=YPT-interacting protein 4;
GN ORFNames=SPAC644.13c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27 AND SER-28, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: May be involved in proper membrane localization of Rab
CC GTPases. {ECO:0000250|UniProtKB:P53093}.
CC -!- SUBUNIT: Interacts with the YIP1 family members yip1 and yip5, and with
CC several Rab GTPases. {ECO:0000250|UniProtKB:P53093}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000255}.
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DR EMBL; CU329670; CAB90140.1; -; Genomic_DNA.
DR RefSeq; NP_593881.1; NM_001019311.2.
DR AlphaFoldDB; Q9P6P8; -.
DR BioGRID; 279990; 18.
DR IntAct; Q9P6P8; 2.
DR STRING; 4896.SPAC644.13c.1; -.
DR iPTMnet; Q9P6P8; -.
DR MaxQB; Q9P6P8; -.
DR PaxDb; Q9P6P8; -.
DR PRIDE; Q9P6P8; -.
DR EnsemblFungi; SPAC644.13c.1; SPAC644.13c.1:pep; SPAC644.13c.
DR GeneID; 2543575; -.
DR KEGG; spo:SPAC644.13c; -.
DR PomBase; SPAC644.13c; -.
DR VEuPathDB; FungiDB:SPAC644.13c; -.
DR eggNOG; KOG2946; Eukaryota.
DR HOGENOM; CLU_059592_3_1_1; -.
DR InParanoid; Q9P6P8; -.
DR OMA; IKFYHVL; -.
DR PhylomeDB; Q9P6P8; -.
DR PRO; PR:Q9P6P8; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; ISO:PomBase.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR InterPro; IPR045231; Yip1/4-like.
DR InterPro; IPR006977; Yip1_dom.
DR PANTHER; PTHR21236; PTHR21236; 1.
DR Pfam; PF04893; Yip1; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..225
FT /note="Protein YIP4"
FT /id="PRO_0000259416"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 27
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 28
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 225 AA; 25310 MW; 613776D071E9FC86 CRC64;
MTDIGKHNTE IEQDEMENLL RMDPVRSSLD VESRAIEPDN IAGESIVETR FTGGDSLDEP
IRVTLFNEFR AIGEKLVYVL YPKNAQVLRD WDLWGPLIFS LVIALALALS TDKIERESVF
TVVVALIWFG EAVCSLNIKL LGANISIFQS MCILGYSSFP LMIASIVCAF VPLIFIRIPV
IVAMYAWTLF AAMGVLQNSN LSNKKLLAVY PLFLFYFSLA WIIFL
