YIP4_YEAST
ID YIP4_YEAST Reviewed; 235 AA.
AC P53093; D6VTV5;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2006, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Protein YIP4;
DE AltName: Full=YPT-interacting protein 4;
GN Name=YIP4; OrderedLocusNames=YGL198W; ORFNames=G1304;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=9046087;
RX DOI=10.1002/(sici)1097-0061(199701)13:1<55::aid-yea48>3.0.co;2-9;
RA Coglievina M., Klima R., Bertani I., Delneri D., Zaccaria P., Bruschi C.V.;
RT "Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII
RT from Saccharomyces cerevisiae.";
RL Yeast 13:55-64(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP INTERACTION WITH SEC4; YIP1; YIP5; YPT1; YPT6; YPT7; YPT10; YPT11; YPT31;
RP YPT32 AND YPT52.
RX PubMed=11943201; DOI=10.1016/s0014-5793(02)02442-0;
RA Calero M., Winand N.J., Collins R.N.;
RT "Identification of the novel proteins Yip4p and Yip5p as Rab GTPase
RT interacting factors.";
RL FEBS Lett. 515:89-98(2002).
RN [5]
RP IDENTIFICATION OF FRAMESHIFTS.
RX PubMed=12748633; DOI=10.1038/nature01644;
RA Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.;
RT "Sequencing and comparison of yeast species to identify genes and
RT regulatory elements.";
RL Nature 423:241-254(2003).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH TVP18; TVP23 AND YIP5.
RX PubMed=17178117; DOI=10.1016/j.yexcr.2006.11.008;
RA Inadome H., Noda Y., Kamimura Y., Adachi H., Yoda K.;
RT "Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-
RT containing Golgi/endosome compartments of Saccharomyces cerevisiae.";
RL Exp. Cell Res. 313:688-697(2007).
CC -!- FUNCTION: May be involved in proper membrane localization of Rab
CC GTPases. {ECO:0000269|PubMed:17178117}.
CC -!- SUBUNIT: Interacts with TVP18, TVP23, YIP1 and YIP5. Interacts with
CC SEC4, YPT1, YPT6, YPT7, YPT10, YPT11, YPT31, YPT32 and YPT52; These
CC proteins are all Rab GTPases. {ECO:0000269|PubMed:11943201,
CC ECO:0000269|PubMed:17178117}.
CC -!- INTERACTION:
CC P53093; P07560: SEC4; NbExp=2; IntAct=EBI-24124, EBI-16858;
CC P53093; P53845: YIF1; NbExp=2; IntAct=EBI-24124, EBI-28230;
CC P53093; P53093: YIP4; NbExp=2; IntAct=EBI-24124, EBI-24124;
CC P53093; P53108: YIP5; NbExp=3; IntAct=EBI-24124, EBI-24051;
CC P53093; P01123: YPT1; NbExp=2; IntAct=EBI-24124, EBI-29496;
CC P53093; P38146: YPT10; NbExp=2; IntAct=EBI-24124, EBI-29357;
CC P53093; P48559: YPT11; NbExp=2; IntAct=EBI-24124, EBI-29362;
CC P53093; P38555: YPT31; NbExp=2; IntAct=EBI-24124, EBI-29379;
CC P53093; P51996: YPT32; NbExp=2; IntAct=EBI-24124, EBI-29384;
CC P53093; P38815: YPT35; NbExp=2; IntAct=EBI-24124, EBI-24665;
CC P53093; P36018: YPT52; NbExp=2; IntAct=EBI-24124, EBI-29407;
CC P53093; Q99260: YPT6; NbExp=2; IntAct=EBI-24124, EBI-29503;
CC P53093; P32939: YPT7; NbExp=2; IntAct=EBI-24124, EBI-29509;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:17178117}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:17178117}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA62946.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA96911.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X91837; CAA62946.1; ALT_FRAME; Genomic_DNA.
DR EMBL; Z72721; CAA96911.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BK006941; DAA07916.1; -; Genomic_DNA.
DR PIR; S62047; S62047.
DR RefSeq; NP_011317.2; NM_001181063.1.
DR AlphaFoldDB; P53093; -.
DR BioGRID; 33059; 83.
DR DIP; DIP-1823N; -.
DR IntAct; P53093; 22.
DR MINT; P53093; -.
DR STRING; 4932.YGL198W; -.
DR TCDB; 9.B.135.1.6; the membrane trafficking yip (yip) family.
DR iPTMnet; P53093; -.
DR PaxDb; P53093; -.
DR PRIDE; P53093; -.
DR EnsemblFungi; YGL198W_mRNA; YGL198W; YGL198W.
DR GeneID; 852676; -.
DR KEGG; sce:YGL198W; -.
DR SGD; S000003166; YIP4.
DR VEuPathDB; FungiDB:YGL198W; -.
DR eggNOG; KOG2946; Eukaryota.
DR GeneTree; ENSGT00940000153168; -.
DR HOGENOM; CLU_1166411_0_0_1; -.
DR InParanoid; P53093; -.
DR OMA; IKFYHVL; -.
DR BioCyc; YEAST:G3O-30679-MON; -.
DR PRO; PR:P53093; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53093; protein.
DR GO; GO:0005794; C:Golgi apparatus; IDA:SGD.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; ISM:SGD.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0031267; F:small GTPase binding; IPI:SGD.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR045231; Yip1/4-like.
DR PANTHER; PTHR21236; PTHR21236; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..235
FT /note="Protein YIP4"
FT /id="PRO_0000202721"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 235 AA; 25995 MW; 642B53FDCCDEA86A CRC64;
MSYGREDTTI EPDFIEPDAP LAASGGVADN IGGTMQNSGS RGTLDETVLQ TLKRDVVEIN
SRLKQVVYPH FPSFFSPSDD GIGAADNDIS ANCDLWAPLA FIILYSLFVS HARSLFSSLF
VSSWFILLVM ALHLRLTKPH QRVSLISYIS ISGYCLFPQV LNALVSQILL PLAYHIGKQN
RWIVRVLSLV KLVVMALCLM WSVAAVSWVT KSKTIIEIYP LALCLFGMAW LSTIL
