YIP5_SCHPO
ID YIP5_SCHPO Reviewed; 249 AA.
AC Q9UTD3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Protein YIP5;
DE AltName: Full=YPT-interacting protein 5;
GN Name=yip5 {ECO:0000250|UniProtKB:P53108}; ORFNames=SPAC227.06;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Possible role in vesicle-mediated transport. May be involved
CC in proper membrane localization of Rab GTPases (By similarity).
CC {ECO:0000250|UniProtKB:P53108}.
CC -!- SUBUNIT: Interacts with the YIP1 family members yip1 and yip4, and
CC several Rab GTPases. The C-terminal cysteines in the Rab GTPase ypt2
CC are essential for the interaction. Interacts with snx3 (By similarity).
CC {ECO:0000250|UniProtKB:P53108}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAB61455.1; -; Genomic_DNA.
DR PIR; T50162; T50162.
DR RefSeq; NP_592960.1; NM_001018360.2.
DR AlphaFoldDB; Q9UTD3; -.
DR BioGRID; 277931; 32.
DR IntAct; Q9UTD3; 1.
DR STRING; 4896.SPAC227.06.1; -.
DR iPTMnet; Q9UTD3; -.
DR MaxQB; Q9UTD3; -.
DR PaxDb; Q9UTD3; -.
DR PRIDE; Q9UTD3; -.
DR EnsemblFungi; SPAC227.06.1; SPAC227.06.1:pep; SPAC227.06.
DR GeneID; 2541426; -.
DR KEGG; spo:SPAC227.06; -.
DR PomBase; SPAC227.06; yip5.
DR VEuPathDB; FungiDB:SPAC227.06; -.
DR eggNOG; KOG3114; Eukaryota.
DR HOGENOM; CLU_059606_2_1_1; -.
DR InParanoid; Q9UTD3; -.
DR OMA; GVLKWYG; -.
DR PhylomeDB; Q9UTD3; -.
DR PRO; PR:Q9UTD3; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; ISO:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; ISO:PomBase.
DR GO; GO:0016192; P:vesicle-mediated transport; ISO:PomBase.
DR InterPro; IPR006977; Yip1_dom.
DR InterPro; IPR039765; Yip5/YIPF1/YIPF2.
DR PANTHER; PTHR12822; PTHR12822; 1.
DR Pfam; PF04893; Yip1; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..249
FT /note="Protein YIP5"
FT /id="PRO_0000259417"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 249 AA; 27932 MW; FAD4EF21883703DC CRC64;
MAHEIEIDSE ADLGRTTFEA EDLYKQRTPI TKPPAPRLQS RRASMQETPW TIKDSFNVET
KDVVQRCIHT LIPTVNFFDV VDDRPDLYGP FWITTTVIQA LFFSNSITEY ARYATGHGTS
GYSIKKLISA ASIIYGYTTI IAVLLWGILV WNKCNPKLLD CLCLYGYANI VWLPVSLATP
PFGLLSTLAS HIVKYVLTGI GLLISIVFLT RNLYPICQQA GSNLCKLLLF GIIVFHCLLA
LSLQLIFFS
