YIP5_YEAST
ID YIP5_YEAST Reviewed; 310 AA.
AC P53108; D6VTZ0;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Protein YIP5;
DE AltName: Full=YPT-interacting protein 5;
GN Name=YIP5; OrderedLocusNames=YGL161C; ORFNames=G1832;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8585324; DOI=10.1002/yea.320111409;
RA James C.M., Indge K.J., Oliver S.G.;
RT "DNA sequence analysis of a 35 kb segment from Saccharomyces cerevisiae
RT chromosome VII reveals 19 open reading frames including RAD54, ACE1/CUP2,
RT PMR1, RCK1, AMS1 and CAL1/CDC43.";
RL Yeast 11:1413-1419(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP INTERACTION WITH SEC4; YIP1; YPT1; YPT7; YPT10; YPT11; YPT31; YPT32 AND
RP YPT52.
RX PubMed=11943201; DOI=10.1016/s0014-5793(02)02442-0;
RA Calero M., Winand N.J., Collins R.N.;
RT "Identification of the novel proteins Yip4p and Yip5p as Rab GTPase
RT interacting factors.";
RL FEBS Lett. 515:89-98(2002).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP INTERACTION WITH SNX3.
RX PubMed=15263065; DOI=10.1074/mcp.m400081-mcp200;
RA Vollert C.S., Uetz P.;
RT "The phox homology (PX) domain protein interaction network in yeast.";
RL Mol. Cell. Proteomics 3:1053-1064(2004).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH TVP18; TVP23 AND YIP4.
RX PubMed=17178117; DOI=10.1016/j.yexcr.2006.11.008;
RA Inadome H., Noda Y., Kamimura Y., Adachi H., Yoda K.;
RT "Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-
RT containing Golgi/endosome compartments of Saccharomyces cerevisiae.";
RL Exp. Cell Res. 313:688-697(2007).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: Possible role in vesicle-mediated transport. May be involved
CC in proper membrane localization of Rab GTPases.
CC {ECO:0000269|PubMed:17178117}.
CC -!- SUBUNIT: Interacts with SNX3, TVP18, TVP23, YIP1 and YIP4. Interacts
CC with SEC4; The C-terminal cysteines in the Rab GTPase SEC4 are
CC essential for the interaction. Interacts with YPT1, YPT6, YPT7, YPT10,
CC YPT11, YPT31, YPT32 and YPT52; These proteins are all Rab GTPases.
CC {ECO:0000269|PubMed:11943201, ECO:0000269|PubMed:15263065,
CC ECO:0000269|PubMed:17178117}.
CC -!- INTERACTION:
CC P53108; P39940: RSP5; NbExp=2; IntAct=EBI-24051, EBI-16219;
CC P53108; P53093: YIP4; NbExp=3; IntAct=EBI-24051, EBI-24124;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 937 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
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DR EMBL; Z48618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z72683; CAA96873.1; -; Genomic_DNA.
DR EMBL; AY557828; AAS56154.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA07951.1; -; Genomic_DNA.
DR PIR; S60425; S60425.
DR RefSeq; NP_011354.3; NM_001181026.3.
DR AlphaFoldDB; P53108; -.
DR BioGRID; 33092; 71.
DR DIP; DIP-1728N; -.
DR IntAct; P53108; 24.
DR MINT; P53108; -.
DR STRING; 4932.YGL161C; -.
DR TCDB; 9.B.135.2.9; the membrane trafficking yip (yip) family.
DR iPTMnet; P53108; -.
DR MaxQB; P53108; -.
DR PaxDb; P53108; -.
DR PRIDE; P53108; -.
DR EnsemblFungi; YGL161C_mRNA; YGL161C; YGL161C.
DR GeneID; 852715; -.
DR KEGG; sce:YGL161C; -.
DR SGD; S000003129; YIP5.
DR VEuPathDB; FungiDB:YGL161C; -.
DR eggNOG; KOG3114; Eukaryota.
DR HOGENOM; CLU_061845_0_0_1; -.
DR InParanoid; P53108; -.
DR OMA; CITITIG; -.
DR BioCyc; YEAST:G3O-30650-MON; -.
DR PRO; PR:P53108; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53108; protein.
DR GO; GO:0005794; C:Golgi apparatus; IDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IPI:SGD.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR006977; Yip1_dom.
DR InterPro; IPR039765; Yip5/YIPF1/YIPF2.
DR PANTHER; PTHR12822; PTHR12822; 1.
DR Pfam; PF04893; Yip1; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..310
FT /note="Protein YIP5"
FT /id="PRO_0000202730"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
SQ SEQUENCE 310 AA; 34843 MW; 2F1477F616FCD602 CRC64;
MPSNNSSFLD IDDDLEGVDD FGNEPNPFDD ATVPDSPNMN NSTAGKGSEF YNTTGSKAES
APLQGQMDPP AYDQVIGQND NDGLGRNGLR PGLINYYSKY FQIDLTQFKK RLSAVLTFRN
DHNSESNEDN TDLYGAVWIT ATVVMINFTM SRGLNFIISD VIEGVKTGED IDRASQFKKL
LHSIWLFYGY TFGVPFITMQ VLNRDEHSER NRSFKSVPEL ISVYGYANLI WIPVCVILNI
LDMSKRLRTV QAIQWAIVAL GWAQSSYFLN SQISSNNNTE TQSNGKFSLS IIVVVALHTL
FCLLFRFIIF
