YIPF1_HUMAN
ID YIPF1_HUMAN Reviewed; 306 AA.
AC Q9Y548; B2RCM7; D3DQ40; Q9NWJ1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Protein YIPF1;
DE AltName: Full=YIP1 family member 1;
GN Name=YIPF1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Adipose tissue, and Synovium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH YIPF2 AND YIPF6.
RX PubMed=28286305; DOI=10.1016/j.yexcr.2017.03.011;
RA Soonthornsit J., Sakai N., Sasaki Y., Watanabe R., Osako S., Nakamura N.;
RT "YIPF1, YIPF2, and YIPF6 are medial-/trans-Golgi and trans-Golgi network-
RT localized Yip domain family proteins, which play a role in the Golgi
RT reassembly and glycan synthesis.";
RL Exp. Cell Res. 353:100-108(2017).
RN [6]
RP SUBCELLULAR LOCATION, AND TOPOLOGY.
RX PubMed=27999994; DOI=10.1007/s00418-016-1527-3;
RA Kranjc T., Dempsey E., Cagney G., Nakamura N., Shields D.C., Simpson J.C.;
RT "Functional characterisation of the YIPF protein family in mammalian
RT cells.";
RL Histochem. Cell Biol. 147:439-451(2017).
CC -!- SUBUNIT: Interacts with YIPF6; this interaction may stabilize YIPF1.
CC May also form a ternary complex with YIPF2 and YIPF6.
CC {ECO:0000269|PubMed:28286305}.
CC -!- INTERACTION:
CC Q9Y548; Q8NCL9: APCDD1L; NbExp=3; IntAct=EBI-7850136, EBI-12904424;
CC Q9Y548; Q13520: AQP6; NbExp=3; IntAct=EBI-7850136, EBI-13059134;
CC Q9Y548; P07307-3: ASGR2; NbExp=3; IntAct=EBI-7850136, EBI-12808270;
CC Q9Y548; O00501: CLDN5; NbExp=3; IntAct=EBI-7850136, EBI-18400628;
CC Q9Y548; Q8TAZ6: CMTM2; NbExp=3; IntAct=EBI-7850136, EBI-2339374;
CC Q9Y548; P34972: CNR2; NbExp=3; IntAct=EBI-7850136, EBI-2835940;
CC Q9Y548; Q15125: EBP; NbExp=3; IntAct=EBI-7850136, EBI-3915253;
CC Q9Y548; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-7850136, EBI-781551;
CC Q9Y548; O14843: FFAR3; NbExp=3; IntAct=EBI-7850136, EBI-17762181;
CC Q9Y548; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-7850136, EBI-13345167;
CC Q9Y548; O15529: GPR42; NbExp=3; IntAct=EBI-7850136, EBI-18076404;
CC Q9Y548; Q9NZD1: GPRC5D; NbExp=3; IntAct=EBI-7850136, EBI-13067820;
CC Q9Y548; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-7850136, EBI-1055254;
CC Q9Y548; P48051: KCNJ6; NbExp=3; IntAct=EBI-7850136, EBI-12017638;
CC Q9Y548; O15243: LEPROT; NbExp=3; IntAct=EBI-7850136, EBI-15672507;
CC Q9Y548; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-7850136, EBI-373355;
CC Q9Y548; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-7850136, EBI-10192441;
CC Q9Y548; Q99942: RNF5; NbExp=3; IntAct=EBI-7850136, EBI-348482;
CC Q9Y548; Q96PQ1: SIGLEC12; NbExp=3; IntAct=EBI-7850136, EBI-17640454;
CC Q9Y548; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-7850136, EBI-18159983;
CC Q9Y548; Q2M3R5: SLC35G1; NbExp=3; IntAct=EBI-7850136, EBI-13311257;
CC Q9Y548; Q9UHI5: SLC7A8; NbExp=3; IntAct=EBI-7850136, EBI-13292283;
CC Q9Y548; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-7850136, EBI-6268651;
CC Q9Y548; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-7850136, EBI-12947623;
CC Q9Y548; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-7850136, EBI-8638294;
CC Q9Y548; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-7850136, EBI-10314986;
CC Q9Y548; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-7850136, EBI-11724433;
CC Q9Y548; Q9Y320: TMX2; NbExp=3; IntAct=EBI-7850136, EBI-6447886;
CC Q9Y548; Q9NYZ1: TVP23B; NbExp=3; IntAct=EBI-7850136, EBI-11343401;
CC Q9Y548; Q3ZAQ7: VMA21; NbExp=3; IntAct=EBI-7850136, EBI-1055364;
CC Q9Y548; Q96EC8: YIPF6; NbExp=8; IntAct=EBI-7850136, EBI-751210;
CC Q9Y548; Q9NXF8-2: ZDHHC7; NbExp=3; IntAct=EBI-7850136, EBI-12948063;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein
CC {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000269|PubMed:27999994, ECO:0000269|PubMed:28286305}. Late
CC endosome membrane {ECO:0000269|PubMed:27999994}. Note=Mainly localizes
CC within medial-/trans-Golgi and trans-Golgi network (TGN), while less so
CC within cis-Golgi. {ECO:0000269|PubMed:27999994,
CC ECO:0000269|PubMed:28286305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y548-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y548-2; Sequence=VSP_019437;
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH09674.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK000823; BAA91389.1; -; mRNA.
DR EMBL; AK315183; BAG37624.1; -; mRNA.
DR EMBL; AL713668; CAD28474.1; -; mRNA.
DR EMBL; CH471059; EAX06727.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX06728.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX06729.1; -; Genomic_DNA.
DR EMBL; BC009674; AAH09674.1; ALT_INIT; mRNA.
DR EMBL; BC064590; AAH64590.1; -; mRNA.
DR CCDS; CCDS584.1; -. [Q9Y548-1]
DR RefSeq; NP_061855.1; NM_018982.4. [Q9Y548-1]
DR RefSeq; XP_016856988.1; XM_017001499.1.
DR AlphaFoldDB; Q9Y548; -.
DR BioGRID; 119948; 41.
DR IntAct; Q9Y548; 35.
DR MINT; Q9Y548; -.
DR STRING; 9606.ENSP00000072644; -.
DR TCDB; 9.B.135.2.3; the membrane trafficking yip (yip) family.
DR GlyGen; Q9Y548; 1 site.
DR iPTMnet; Q9Y548; -.
DR PhosphoSitePlus; Q9Y548; -.
DR BioMuta; YIPF1; -.
DR DMDM; 74735280; -.
DR EPD; Q9Y548; -.
DR jPOST; Q9Y548; -.
DR MassIVE; Q9Y548; -.
DR MaxQB; Q9Y548; -.
DR PaxDb; Q9Y548; -.
DR PeptideAtlas; Q9Y548; -.
DR PRIDE; Q9Y548; -.
DR ProteomicsDB; 86289; -. [Q9Y548-1]
DR Antibodypedia; 3081; 89 antibodies from 17 providers.
DR DNASU; 54432; -.
DR Ensembl; ENST00000072644.7; ENSP00000072644.1; ENSG00000058799.15. [Q9Y548-1]
DR Ensembl; ENST00000371399.5; ENSP00000360452.1; ENSG00000058799.15. [Q9Y548-2]
DR Ensembl; ENST00000464950.6; ENSP00000432266.1; ENSG00000058799.15. [Q9Y548-1]
DR GeneID; 54432; -.
DR KEGG; hsa:54432; -.
DR MANE-Select; ENST00000072644.7; ENSP00000072644.1; NM_018982.5; NP_061855.1.
DR UCSC; uc001cvu.4; human. [Q9Y548-1]
DR CTD; 54432; -.
DR DisGeNET; 54432; -.
DR GeneCards; YIPF1; -.
DR HGNC; HGNC:25231; YIPF1.
DR HPA; ENSG00000058799; Low tissue specificity.
DR MIM; 617521; gene.
DR neXtProt; NX_Q9Y548; -.
DR OpenTargets; ENSG00000058799; -.
DR PharmGKB; PA142670555; -.
DR VEuPathDB; HostDB:ENSG00000058799; -.
DR eggNOG; KOG3114; Eukaryota.
DR GeneTree; ENSGT00390000010157; -.
DR HOGENOM; CLU_059606_1_0_1; -.
DR InParanoid; Q9Y548; -.
DR OMA; GVLKWYG; -.
DR OrthoDB; 1425332at2759; -.
DR PhylomeDB; Q9Y548; -.
DR TreeFam; TF313536; -.
DR PathwayCommons; Q9Y548; -.
DR SignaLink; Q9Y548; -.
DR BioGRID-ORCS; 54432; 8 hits in 1076 CRISPR screens.
DR ChiTaRS; YIPF1; human.
DR GeneWiki; YIPF1; -.
DR GenomeRNAi; 54432; -.
DR Pharos; Q9Y548; Tbio.
DR PRO; PR:Q9Y548; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9Y548; protein.
DR Bgee; ENSG00000058799; Expressed in islet of Langerhans and 198 other tissues.
DR Genevisible; Q9Y548; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0005797; C:Golgi medial cisterna; IDA:UniProtKB.
DR GO; GO:0000138; C:Golgi trans cisterna; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
DR GO; GO:0030133; C:transport vesicle; IDA:LIFEdb.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR006977; Yip1_dom.
DR InterPro; IPR039765; Yip5/YIPF1/YIPF2.
DR PANTHER; PTHR12822; PTHR12822; 1.
DR Pfam; PF04893; Yip1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endosome; Glycoprotein; Golgi apparatus; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..306
FT /note="Protein YIPF1"
FT /id="PRO_0000240868"
FT TOPO_DOM 1..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:27999994"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..162
FT /note="Lumenal"
FT /evidence="ECO:0000269|PubMed:27999994"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:27999994"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..227
FT /note="Lumenal"
FT /evidence="ECO:0000269|PubMed:27999994"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:27999994"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..306
FT /note="Lumenal"
FT /evidence="ECO:0000305|PubMed:27999994"
FT REGION 14..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 297
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..183
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_019437"
FT CONFLICT 109
FT /note="F -> L (in Ref. 4; AAH09674)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 306 AA; 34277 MW; FC147CD5F9CAF467 CRC64;
MAAVDDLQFE EFGNAATSLT ANPDATTVNI EDPGETPKHQ PGSPRGSGRE EDDELLGNDD
SDKTELLAGQ KKSSPFWTFE YYQTFFDVDT YQVFDRIKGS LLPIPGKNFV RLYIRSNPDL
YGPFWICATL VFAIAISGNL SNFLIHLGEK TYHYVPEFRK VSIAATIIYA YAWLVPLALW
GFLMWRNSKV MNIVSYSFLE IVCVYGYSLF IYIPTAILWI IPQKAVRWIL VMIALGISGS
LLAMTFWPAV REDNRRVALA TIVTIVLLHM LLSVGCLAYF FDAPEMDHLP TTTATPNQTV
AAAKSS
