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YIPF1_MOUSE
ID   YIPF1_MOUSE             Reviewed;         306 AA.
AC   Q91VU1; Q3TZU1;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Protein YIPF1;
DE   AltName: Full=YIP1 family member 1;
GN   Name=Yipf1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Corpus striatum, and Spleen;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with YIPF6; this interaction may stabilize YIPF1.
CC       May also form a ternary complex with YIPF2 and YIPF6.
CC       {ECO:0000250|UniProtKB:Q9Y548}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
CC       {ECO:0000250|UniProtKB:Q9Y548}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y548}. Golgi apparatus, trans-Golgi network
CC       membrane {ECO:0000250|UniProtKB:Q9Y548}. Late endosome membrane
CC       {ECO:0000250|UniProtKB:Q9Y548}. Note=Mainly localizes within
CC       medial-/trans-Golgi and trans-Golgi network (TGN), while less so within
CC       cis-Golgi. {ECO:0000250|UniProtKB:Q9Y548}.
CC   -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
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DR   EMBL; AK081205; BAC38163.1; -; mRNA.
DR   EMBL; AK157536; BAE34116.1; -; mRNA.
DR   EMBL; BC009080; AAH09080.1; -; mRNA.
DR   CCDS; CCDS18437.1; -.
DR   RefSeq; NP_663525.1; NM_145550.3.
DR   AlphaFoldDB; Q91VU1; -.
DR   STRING; 10090.ENSMUSP00000075113; -.
DR   GlyGen; Q91VU1; 1 site.
DR   iPTMnet; Q91VU1; -.
DR   PhosphoSitePlus; Q91VU1; -.
DR   MaxQB; Q91VU1; -.
DR   PaxDb; Q91VU1; -.
DR   PRIDE; Q91VU1; -.
DR   ProteomicsDB; 299621; -.
DR   Antibodypedia; 3081; 89 antibodies from 17 providers.
DR   DNASU; 230584; -.
DR   Ensembl; ENSMUST00000075693; ENSMUSP00000075113; ENSMUSG00000057375.
DR   GeneID; 230584; -.
DR   KEGG; mmu:230584; -.
DR   UCSC; uc008tzs.2; mouse.
DR   CTD; 54432; -.
DR   MGI; MGI:1915532; Yipf1.
DR   VEuPathDB; HostDB:ENSMUSG00000057375; -.
DR   eggNOG; KOG3114; Eukaryota.
DR   GeneTree; ENSGT00390000010157; -.
DR   HOGENOM; CLU_059606_1_0_1; -.
DR   InParanoid; Q91VU1; -.
DR   OMA; GVLKWYG; -.
DR   OrthoDB; 1425332at2759; -.
DR   PhylomeDB; Q91VU1; -.
DR   TreeFam; TF313536; -.
DR   BioGRID-ORCS; 230584; 3 hits in 73 CRISPR screens.
DR   ChiTaRS; Yipf1; mouse.
DR   PRO; PR:Q91VU1; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q91VU1; protein.
DR   Bgee; ENSMUSG00000057375; Expressed in choroid plexus of fourth ventricle and 257 other tissues.
DR   ExpressionAtlas; Q91VU1; baseline and differential.
DR   Genevisible; Q91VU1; MM.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR   GO; GO:0005797; C:Golgi medial cisterna; ISS:UniProtKB.
DR   GO; GO:0000138; C:Golgi trans cisterna; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR   GO; GO:0030133; C:transport vesicle; ISO:MGI.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR006977; Yip1_dom.
DR   InterPro; IPR039765; Yip5/YIPF1/YIPF2.
DR   PANTHER; PTHR12822; PTHR12822; 1.
DR   Pfam; PF04893; Yip1; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Glycoprotein; Golgi apparatus; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..306
FT                   /note="Protein YIPF1"
FT                   /id="PRO_0000240869"
FT   TOPO_DOM        1..119
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y548"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141..162
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..200
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..227
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..256
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        278..306
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y548"
FT   REGION          30..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        297
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        120
FT                   /note="L -> F (in Ref. 1; BAE34116)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   306 AA;  34258 MW;  680A5C88F750BA3A CRC64;
     MAAVDDLQFE EFGDGATLLA ANPDATTINI EDPSVSFGHQ PRPPGSVGRE EDEELLGNND
     SDETELLAGQ KRSSPFWTFE YYQTFFDVDT YQVFDRIKGS LLPVPGKNFV RLYIRSNPDL
     YGPFWICATL VFAIAISGNL SNFLIHLGEK TYHYVPEFQK VSIAATVIYA YAWLVPLALW
     GFLLWRNSKV MSMVSYSFLE IVCVYGYSLF IYIPTAVLWI IPQRVVRWVL VMIALGVSGS
     VLVMTFWPAV REDNRRVALA TIVTIVLLHV LLSVGCLAYF FDAPEMDHLP AAITTPNQTV
     TAAKSS
 
 
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