YIPF2_MOUSE
ID YIPF2_MOUSE Reviewed; 312 AA.
AC Q99LP8; Q99LF3;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein YIPF2;
DE AltName: Full=YIP1 family member 2;
GN Name=Yipf2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, and Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with YIPF6; this interaction may stabilize YIPF2.
CC May also form a ternary complex with YIPF1 and YIPF6.
CC {ECO:0000250|UniProtKB:Q9BWQ6}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000250|UniProtKB:Q9BWQ6}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9BWQ6}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000250|UniProtKB:Q9BWQ6}. Late endosome membrane
CC {ECO:0000250|UniProtKB:Q9BWQ6}. Note=Mainly localizes within
CC medial-/trans-Golgi and trans-Golgi network (TGN), while less so within
CC cis-Golgi. {ECO:0000250|UniProtKB:Q9BWQ6}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
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DR EMBL; AK033705; BAC28437.1; -; mRNA.
DR EMBL; AK133631; BAE21759.1; -; mRNA.
DR EMBL; BC002282; AAH02282.1; -; mRNA.
DR EMBL; BC003289; AAH03289.1; -; mRNA.
DR CCDS; CCDS22907.1; -.
DR RefSeq; NP_001192086.1; NM_001205157.1.
DR RefSeq; NP_001192087.1; NM_001205158.1.
DR RefSeq; NP_612176.1; NM_138303.2.
DR RefSeq; XP_011240919.1; XM_011242617.1.
DR RefSeq; XP_011240920.1; XM_011242618.2.
DR RefSeq; XP_017169160.1; XM_017313671.1.
DR AlphaFoldDB; Q99LP8; -.
DR STRING; 10090.ENSMUSP00000034700; -.
DR iPTMnet; Q99LP8; -.
DR PhosphoSitePlus; Q99LP8; -.
DR MaxQB; Q99LP8; -.
DR PaxDb; Q99LP8; -.
DR PRIDE; Q99LP8; -.
DR ProteomicsDB; 299606; -.
DR Antibodypedia; 13058; 27 antibodies from 15 providers.
DR Ensembl; ENSMUST00000034700; ENSMUSP00000034700; ENSMUSG00000032182.
DR Ensembl; ENSMUST00000078572; ENSMUSP00000077649; ENSMUSG00000032182.
DR Ensembl; ENSMUST00000180365; ENSMUSP00000136463; ENSMUSG00000032182.
DR GeneID; 74766; -.
DR KEGG; mmu:74766; -.
DR UCSC; uc009olx.2; mouse.
DR CTD; 78992; -.
DR MGI; MGI:1922016; Yipf2.
DR VEuPathDB; HostDB:ENSMUSG00000032182; -.
DR eggNOG; KOG3114; Eukaryota.
DR GeneTree; ENSGT00390000010157; -.
DR HOGENOM; CLU_059606_1_1_1; -.
DR InParanoid; Q99LP8; -.
DR OMA; AIGCKMY; -.
DR OrthoDB; 1425332at2759; -.
DR PhylomeDB; Q99LP8; -.
DR TreeFam; TF313536; -.
DR BioGRID-ORCS; 74766; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Yipf2; mouse.
DR PRO; PR:Q99LP8; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q99LP8; protein.
DR Bgee; ENSMUSG00000032182; Expressed in rostral migratory stream and 243 other tissues.
DR ExpressionAtlas; Q99LP8; baseline and differential.
DR Genevisible; Q99LP8; MM.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005797; C:Golgi medial cisterna; ISS:UniProtKB.
DR GO; GO:0000138; C:Golgi trans cisterna; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR GO; GO:0030133; C:transport vesicle; ISO:MGI.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR006977; Yip1_dom.
DR InterPro; IPR039765; Yip5/YIPF1/YIPF2.
DR PANTHER; PTHR12822; PTHR12822; 1.
DR Pfam; PF04893; Yip1; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Endosome; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9BWQ6"
FT CHAIN 2..312
FT /note="Protein YIPF2"
FT /id="PRO_0000241455"
FT TOPO_DOM 2..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9BWQ6"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..160
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..228
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..312
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q9BWQ6"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9BWQ6"
FT CONFLICT 227
FT /note="L -> F (in Ref. 2; AAH03289)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 34900 MW; 36448819FF529F7D CRC64;
MAAADELAFH EFEEATNLLA ETPDAATTSQ SDELTSREHV AVVVGSGIGY GAEVGEEEDD
KTSLLQEEKP QPRFWTFDYY QSFFDVDTSQ VLDRIKGSLL PHPGHNFVRH HLRNRPDLYG
PFWICATLAF VLAVTGNLTL VLAQRRDPSI HYSPQFHKVT IAGITIYCYA WLVPLALWGF
LRWRQGTRER MGLYTFLETV CVYGYSLFVF IPTVVLWLIP VQWIQWLFGA LGLALSAAGL
VFTLWPVVRE DTRLVAAALL STVVLLHALL ALGCKLYFFQ PLPLDHVVPA PQATPPSPNV
LLPSSIQPMT TS
