YIPF3_MOUSE
ID YIPF3_MOUSE Reviewed; 347 AA.
AC Q3UDR8; Q8C998; Q8K5D1; Q8VCS2;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein YIPF3;
DE AltName: Full=Killer lineage protein 1;
DE AltName: Full=YIP1 family member 3;
DE Contains:
DE RecName: Full=Protein YIPF3, N-terminally processed;
GN Name=Yipf3; Synonyms=D17Wsu94e, Klip1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 1-12, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 25-193, AND TISSUE SPECIFICITY.
RX PubMed=12490290; DOI=10.1006/bcmd.2002.0563;
RA Prost S., LeDiscorde M., Haddad R., Gluckman J.-C., Canque B.,
RA Kirszenbaum M.;
RT "Characterization of a novel hematopoietic marker expressed from early
RT embryonic hematopoietic stem cells to adult mature lineages.";
RL Blood Cells Mol. Dis. 29:236-248(2002).
CC -!- FUNCTION: Involved in the maintenance of the Golgi structure. May play
CC a role in hematopoiesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with YIPF4 and YIPF5.
CC {ECO:0000250|UniProtKB:Q9GZM5}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein. Golgi apparatus, cis-Golgi network membrane {ECO:0000250};
CC Multi-pass membrane protein. Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by splenocytes (at protein level).
CC {ECO:0000269|PubMed:12490290}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC31317.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK149957; BAE29193.1; -; mRNA.
DR EMBL; AK042644; BAC31317.1; ALT_INIT; mRNA.
DR EMBL; BC019384; AAH19384.1; -; mRNA.
DR EMBL; AF197931; AAM21162.1; -; mRNA.
DR CCDS; CCDS28823.1; -.
DR RefSeq; NP_663328.2; NM_145353.2.
DR AlphaFoldDB; Q3UDR8; -.
DR BioGRID; 205747; 4.
DR STRING; 10090.ENSMUSP00000092897; -.
DR GlyGen; Q3UDR8; 1 site.
DR iPTMnet; Q3UDR8; -.
DR PhosphoSitePlus; Q3UDR8; -.
DR EPD; Q3UDR8; -.
DR MaxQB; Q3UDR8; -.
DR PaxDb; Q3UDR8; -.
DR PeptideAtlas; Q3UDR8; -.
DR PRIDE; Q3UDR8; -.
DR ProteomicsDB; 299622; -.
DR Antibodypedia; 3101; 118 antibodies from 23 providers.
DR DNASU; 28064; -.
DR Ensembl; ENSMUST00000095263; ENSMUSP00000092897; ENSMUSG00000071074.
DR GeneID; 28064; -.
DR KEGG; mmu:28064; -.
DR UCSC; uc008csd.2; mouse.
DR CTD; 25844; -.
DR MGI; MGI:106280; Yipf3.
DR VEuPathDB; HostDB:ENSMUSG00000071074; -.
DR eggNOG; KOG3114; Eukaryota.
DR GeneTree; ENSGT00940000153766; -.
DR HOGENOM; CLU_068070_0_0_1; -.
DR InParanoid; Q3UDR8; -.
DR OMA; HCIVLFV; -.
DR OrthoDB; 1332379at2759; -.
DR PhylomeDB; Q3UDR8; -.
DR TreeFam; TF314073; -.
DR BioGRID-ORCS; 28064; 3 hits in 76 CRISPR screens.
DR ChiTaRS; Yipf3; mouse.
DR PRO; PR:Q3UDR8; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q3UDR8; protein.
DR Bgee; ENSMUSG00000071074; Expressed in right kidney and 243 other tissues.
DR ExpressionAtlas; Q3UDR8; baseline and differential.
DR Genevisible; Q3UDR8; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030133; C:transport vesicle; ISO:MGI.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR InterPro; IPR026637; YIPF3.
DR PANTHER; PTHR15627:SF14; PTHR15627:SF14; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell membrane; Cytoplasm; Differentiation;
KW Direct protein sequencing; Glycoprotein; Golgi apparatus; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..347
FT /note="Protein YIPF3"
FT /id="PRO_0000244447"
FT INIT_MET 1
FT /note="Removed; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9GZM5"
FT CHAIN 2..347
FT /note="Protein YIPF3, N-terminally processed"
FT /id="PRO_0000424523"
FT TOPO_DOM 2..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9GZM5"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..184
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..211
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 212..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..237
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 238..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..347
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q9GZM5"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine; in Protein YIPF3, N-terminally
FT processed"
FT /evidence="ECO:0000250|UniProtKB:Q9GZM5"
FT CARBOHYD 334
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 333
FT /note="I -> V (in Ref. 2; AAH19384)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 347 AA; 37998 MW; BE3CFD310CD52739 CRC64;
MATPAAPASG VRNGAGPEWG GFEENIQGGG SAVIDMENMD DTSGSSFEDM GELHQRLREE
EVDADAAAAE EEDGEFLGMK GFKGQLSRQV ADQMWQAGKR QASRAFSLYA NIDILRPYFD
VEPAQVRSRL LESMIPIKMV NFPQKVAGEL YGPLMLVFTL VAILLHGMKT SDTIIREGTL
MGTAIGTCFG YWLGVSSFIY FLAYLCNAQI TMLQMLALLG YGLFGHCIVL FITYNIHLHA
LFYLFWLLVG GLSTLRMVAV LVSRTVGPTQ RLLLCGTLAA LHMLFLLYLH FAYHKVVEGI
LDTLEGPNIP PMQRVPRDIP AVLPAARLPV AVINATAKAI AVTLQSH
