YIPF4_HUMAN
ID YIPF4_HUMAN Reviewed; 244 AA.
AC Q9BSR8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Protein YIPF4;
DE AltName: Full=YIP1 family member 4;
GN Name=YIPF4; ORFNames=Nbla11189;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neuroblastoma;
RX PubMed=12880961; DOI=10.1016/s0304-3835(03)00085-5;
RA Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S.,
RA Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S.,
RA Hirato J., Nakagawara A.;
RT "Neuroblastoma oligo-capping cDNA project: toward the understanding of the
RT genesis and biology of neuroblastoma.";
RL Cancer Lett. 197:63-68(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastric mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH YIPF3.
RX PubMed=21757827; DOI=10.1247/csf.11002;
RA Tanimoto K., Suzuki K., Jokitalo E., Sakai N., Sakaguchi T., Tamura D.,
RA Fujii G., Aoki K., Takada S., Ishida R., Tanabe M., Itoh H., Yoneda Y.,
RA Sohda M., Misumi Y., Nakamura N.;
RT "Characterization of YIPF3 and YIPF4, cis-Golgi localizing Yip domain
RT family proteins.";
RL Cell Struct. Funct. 36:171-185(2011).
RN [6]
RP INTERACTION WITH HPV E5 PROTEINS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RX PubMed=26235900; DOI=10.1038/srep12523;
RA Mueller M., Wasson C.W., Bhatia R., Boxall S., Millan D., Goh G.Y.,
RA Haas J., Stonehouse N.J., Macdonald A.;
RT "YIP1 family member 4 (YIPF4) is a novel cellular binding partner of the
RT papillomavirus E5 proteins.";
RL Sci. Rep. 5:12523-12523(2015).
RN [7]
RP SUBCELLULAR LOCATION, TOPOLOGY, AND INTERACTION WITH YIPF3 AND YIPF5.
RX PubMed=27999994; DOI=10.1007/s00418-016-1527-3;
RA Kranjc T., Dempsey E., Cagney G., Nakamura N., Shields D.C., Simpson J.C.;
RT "Functional characterisation of the YIPF protein family in mammalian
RT cells.";
RL Histochem. Cell Biol. 147:439-451(2017).
CC -!- FUNCTION: Involved in the maintenance of the Golgi structure.
CC {ECO:0000269|PubMed:21757827}.
CC -!- SUBUNIT: Interacts with YIPF3 and YIPF5. {ECO:0000269|PubMed:21757827,
CC ECO:0000269|PubMed:27999994}.
CC -!- SUBUNIT: (Microbial infection) Interacts with human papillomavirus
CC (HPV) E5 proteins. {ECO:0000269|PubMed:26235900}.
CC -!- INTERACTION:
CC Q9BSR8; Q13520: AQP6; NbExp=3; IntAct=EBI-751253, EBI-13059134;
CC Q9BSR8; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-751253, EBI-714543;
CC Q9BSR8; P11912: CD79A; NbExp=3; IntAct=EBI-751253, EBI-7797864;
CC Q9BSR8; P34972: CNR2; NbExp=3; IntAct=EBI-751253, EBI-2835940;
CC Q9BSR8; Q15125: EBP; NbExp=3; IntAct=EBI-751253, EBI-3915253;
CC Q9BSR8; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-751253, EBI-781551;
CC Q9BSR8; Q969F0: FATE1; NbExp=6; IntAct=EBI-751253, EBI-743099;
CC Q9BSR8; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-751253, EBI-13345167;
CC Q9BSR8; O15529: GPR42; NbExp=3; IntAct=EBI-751253, EBI-18076404;
CC Q9BSR8; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-751253, EBI-18053395;
CC Q9BSR8; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-751253, EBI-725665;
CC Q9BSR8; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-751253, EBI-373355;
CC Q9BSR8; Q9UHE5: NAT8; NbExp=3; IntAct=EBI-751253, EBI-2863634;
CC Q9BSR8; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-751253, EBI-7545592;
CC Q9BSR8; Q96GF1: RNF185; NbExp=3; IntAct=EBI-751253, EBI-2340249;
CC Q9BSR8; Q99942: RNF5; NbExp=3; IntAct=EBI-751253, EBI-348482;
CC Q9BSR8; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-751253, EBI-17247926;
CC Q9BSR8; Q14973: SLC10A1; NbExp=3; IntAct=EBI-751253, EBI-3923031;
CC Q9BSR8; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-751253, EBI-17595455;
CC Q9BSR8; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-751253, EBI-10262251;
CC Q9BSR8; Q96G79: SLC35A4; NbExp=3; IntAct=EBI-751253, EBI-12363689;
CC Q9BSR8; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-751253, EBI-17295964;
CC Q9BSR8; P30825: SLC7A1; NbExp=4; IntAct=EBI-751253, EBI-4289564;
CC Q9BSR8; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-751253, EBI-5235586;
CC Q9BSR8; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-751253, EBI-12947623;
CC Q9BSR8; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-751253, EBI-8638294;
CC Q9BSR8; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-751253, EBI-12003468;
CC Q9BSR8; Q9NYZ1: TVP23B; NbExp=3; IntAct=EBI-751253, EBI-11343401;
CC Q9BSR8; O95070: YIF1A; NbExp=3; IntAct=EBI-751253, EBI-2799703;
CC Q9BSR8; Q9GZM5: YIPF3; NbExp=10; IntAct=EBI-751253, EBI-743787;
CC Q9BSR8; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-751253, EBI-12837904;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000269|PubMed:21757827, ECO:0000269|PubMed:26235900,
CC ECO:0000269|PubMed:27999994}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:21757827}.
CC -!- TISSUE SPECIFICITY: Expressed in keratinocytes (at protein level).
CC {ECO:0000269|PubMed:26235900}.
CC -!- DEVELOPMENTAL STAGE: In primary foreskin keratinocytes, down-regulated
CC during calcium-induced differentiation (at protein level). The
CC physiological relevance of this observation is unclear as YIPF4 protein
CC is expressed throughout the epithelial layers in organotypic raft
CC cultures, a cell-culture model of stratified epithelium.
CC {ECO:0000269|PubMed:26235900}.
CC -!- DEVELOPMENTAL STAGE: (Microbial infection) Down-regulation upon
CC calcium-induced keratinocyte differentiation is prevented in the
CC presence of human papillomavirus (HPV), independently of HPV E5 protein
CC (at protein level). The physiological relevance of this observation is
CC unclear. {ECO:0000269|PubMed:26235900}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB072898; BAE45710.1; -; mRNA.
DR EMBL; AK098486; BAC05315.1; -; mRNA.
DR EMBL; BC004875; AAH04875.1; -; mRNA.
DR CCDS; CCDS1781.1; -.
DR RefSeq; NP_115688.1; NM_032312.3.
DR AlphaFoldDB; Q9BSR8; -.
DR BioGRID; 123999; 59.
DR IntAct; Q9BSR8; 53.
DR MINT; Q9BSR8; -.
DR STRING; 9606.ENSP00000238831; -.
DR iPTMnet; Q9BSR8; -.
DR PhosphoSitePlus; Q9BSR8; -.
DR SwissPalm; Q9BSR8; -.
DR BioMuta; YIPF4; -.
DR DMDM; 74733045; -.
DR EPD; Q9BSR8; -.
DR jPOST; Q9BSR8; -.
DR MassIVE; Q9BSR8; -.
DR MaxQB; Q9BSR8; -.
DR PaxDb; Q9BSR8; -.
DR PeptideAtlas; Q9BSR8; -.
DR PRIDE; Q9BSR8; -.
DR ProteomicsDB; 78921; -.
DR Antibodypedia; 14283; 97 antibodies from 24 providers.
DR DNASU; 84272; -.
DR Ensembl; ENST00000238831.9; ENSP00000238831.3; ENSG00000119820.11.
DR GeneID; 84272; -.
DR KEGG; hsa:84272; -.
DR MANE-Select; ENST00000238831.9; ENSP00000238831.3; NM_032312.4; NP_115688.1.
DR UCSC; uc002rok.4; human.
DR CTD; 84272; -.
DR DisGeNET; 84272; -.
DR GeneCards; YIPF4; -.
DR HGNC; HGNC:28145; YIPF4.
DR HPA; ENSG00000119820; Group enriched (brain, choroid plexus).
DR MIM; 617534; gene.
DR neXtProt; NX_Q9BSR8; -.
DR OpenTargets; ENSG00000119820; -.
DR PharmGKB; PA142670547; -.
DR VEuPathDB; HostDB:ENSG00000119820; -.
DR eggNOG; KOG3103; Eukaryota.
DR GeneTree; ENSGT00940000153168; -.
DR HOGENOM; CLU_072083_0_0_1; -.
DR InParanoid; Q9BSR8; -.
DR OMA; TMWFCGG; -.
DR OrthoDB; 1242956at2759; -.
DR PhylomeDB; Q9BSR8; -.
DR TreeFam; TF315055; -.
DR PathwayCommons; Q9BSR8; -.
DR SignaLink; Q9BSR8; -.
DR BioGRID-ORCS; 84272; 11 hits in 1042 CRISPR screens.
DR ChiTaRS; YIPF4; human.
DR GeneWiki; YIPF4; -.
DR GenomeRNAi; 84272; -.
DR Pharos; Q9BSR8; Tdark.
DR PRO; PR:Q9BSR8; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9BSR8; protein.
DR Bgee; ENSG00000119820; Expressed in calcaneal tendon and 183 other tissues.
DR ExpressionAtlas; Q9BSR8; baseline and differential.
DR Genevisible; Q9BSR8; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IBA:GO_Central.
DR InterPro; IPR045231; Yip1/4-like.
DR InterPro; IPR006977; Yip1_dom.
DR PANTHER; PTHR21236; PTHR21236; 1.
DR Pfam; PF04893; Yip1; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Host-virus interaction; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..244
FT /note="Protein YIPF4"
FT /id="PRO_0000242632"
FT TOPO_DOM 1..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:27999994"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..138
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..166
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..195
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..223
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 244 AA; 27083 MW; BEC6F8EA9892F612 CRC64;
MQPPGPPPAY APTNGDFTFV SSADAEDLSG SIASPDVKLN LGGDFIKEST ATTFLRQRGY
GWLLEVEDDD PEDNKPLLEE LDIDLKDIYY KIRCVLMPMP SLGFNRQVVR DNPDFWGPLA
VVLFFSMISL YGQFRVVSWI ITIWIFGSLT IFLLARVLGG EVAYGQVLGV IGYSLLPLIV
IAPVLLVVGS FEVVSTLIKL FGVFWAAYSA ASLLVGEEFK TKKPLLIYPI FLLYIYFLSL
YTGV
