ID   CBIE_SALTI              Reviewed;         201 AA.
AC   P0A2H2; Q05629;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Cobalt-precorrin-7 C(5)-methyltransferase;
DE            EC=2.1.1.289;
DE   AltName: Full=Cobalt-precorrin-6Y C(5)-methyltransferase;
DE            Short=Cobalt-precorrin-6 methyltransferase;
DE            Short=Cobalt-precorrin-6Y methylase;
GN   Name=cbiE; OrderedLocusNames=STY2236, t0843;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Catalyzes the methylation of C-5 in cobalt-precorrin-7 to
CC       form cobalt-precorrin-8.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co-precorrin-7 + S-adenosyl-L-methionine = Co-precorrin-8X +
CC         H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:34591,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:70791, ChEBI:CHEBI:70792; EC=2.1.1.289;
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 8/10.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AL513382; CAD02392.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO68530.1; -; Genomic_DNA.
DR   RefSeq; NP_456582.1; NC_003198.1.
DR   RefSeq; WP_000958833.1; NZ_WSUR01000002.1.
DR   AlphaFoldDB; P0A2H2; -.
DR   SMR; P0A2H2; -.
DR   STRING; 220341.16503263; -.
DR   EnsemblBacteria; AAO68530; AAO68530; t0843.
DR   KEGG; stt:t0843; -.
DR   KEGG; sty:STY2236; -.
DR   PATRIC; fig|220341.7.peg.2255; -.
DR   eggNOG; COG2241; Bacteria.
DR   HOGENOM; CLU_089162_2_0_6; -.
DR   OMA; DPCFSGL; -.
DR   UniPathway; UPA00148; UER00229.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0043777; F:cobalt-precorrin-7 C15-methyltransferase activity; IEA:RHEA.
DR   GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd11644; Precorrin-6Y-MT; 1.
DR   Gene3D; 3.30.950.10; -; 1.
DR   Gene3D; 3.40.1010.10; -; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR012818; CbiE.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF53790; SSF53790; 1.
DR   TIGRFAMs; TIGR02467; CbiE; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis; Methyltransferase; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..201
FT                   /note="Cobalt-precorrin-7 C(5)-methyltransferase"
FT                   /id="PRO_0000150406"
SQ   SEQUENCE   201 AA;  21778 MW;  24D2F30887703FB1 CRC64;
     MLTVVGMGPA GRHLMTPAAL EAIDHADALA GGKRHLAQFP AFGGERFTLG ADIGALLSWI
     AARRDKGIVV LASGDPLFYG IGTRLVAHFG IEQVRIIPGI SAVQYLCAQA GIDMNDMWLT
     SSHGRCVSFE QLANHRKVAM VTDARCGPRE IARELVARGK GHRLMVIGEN LAMENERIHW
     LPVSAVNADY EMNAVVILDE R