YIPF4_MOUSE
ID YIPF4_MOUSE Reviewed; 246 AA.
AC Q8C407; Q99KZ9;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein YIPF4;
DE AltName: Full=YIP1 family member 4;
GN Name=Yipf4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Mammary gland, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in the maintenance of the Golgi structure.
CC {ECO:0000250|UniProtKB:Q9BSR8}.
CC -!- SUBUNIT: Interacts with YIPF3 and YIPF5.
CC {ECO:0000250|UniProtKB:Q9BSR8}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000250|UniProtKB:Q9BSR8}; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C407-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C407-2; Sequence=VSP_019457;
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
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DR EMBL; AK083301; BAC38852.1; -; mRNA.
DR EMBL; AK159227; BAE34913.1; -; mRNA.
DR EMBL; AK166347; BAE38721.1; -; mRNA.
DR EMBL; BC003936; AAH03936.1; -; mRNA.
DR CCDS; CCDS28971.1; -. [Q8C407-1]
DR RefSeq; NP_080693.2; NM_026417.4. [Q8C407-1]
DR AlphaFoldDB; Q8C407; -.
DR BioGRID; 212491; 2.
DR IntAct; Q8C407; 2.
DR STRING; 10090.ENSMUSP00000024873; -.
DR iPTMnet; Q8C407; -.
DR PhosphoSitePlus; Q8C407; -.
DR EPD; Q8C407; -.
DR jPOST; Q8C407; -.
DR MaxQB; Q8C407; -.
DR PaxDb; Q8C407; -.
DR PeptideAtlas; Q8C407; -.
DR PRIDE; Q8C407; -.
DR ProteomicsDB; 299627; -. [Q8C407-1]
DR ProteomicsDB; 299628; -. [Q8C407-2]
DR TopDownProteomics; Q8C407-1; -. [Q8C407-1]
DR Antibodypedia; 14283; 97 antibodies from 24 providers.
DR DNASU; 67864; -.
DR Ensembl; ENSMUST00000024873; ENSMUSP00000024873; ENSMUSG00000024072. [Q8C407-1]
DR GeneID; 67864; -.
DR KEGG; mmu:67864; -.
DR UCSC; uc008dod.2; mouse. [Q8C407-1]
DR UCSC; uc012axg.2; mouse. [Q8C407-2]
DR CTD; 84272; -.
DR MGI; MGI:1915114; Yipf4.
DR VEuPathDB; HostDB:ENSMUSG00000024072; -.
DR eggNOG; KOG3103; Eukaryota.
DR GeneTree; ENSGT00940000153168; -.
DR HOGENOM; CLU_072083_0_0_1; -.
DR InParanoid; Q8C407; -.
DR OMA; TMWFCGG; -.
DR OrthoDB; 1242956at2759; -.
DR PhylomeDB; Q8C407; -.
DR TreeFam; TF315055; -.
DR BioGRID-ORCS; 67864; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Yipf4; mouse.
DR PRO; PR:Q8C407; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8C407; protein.
DR Bgee; ENSMUSG00000024072; Expressed in seminal vesicle and 257 other tissues.
DR ExpressionAtlas; Q8C407; baseline and differential.
DR Genevisible; Q8C407; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IBA:GO_Central.
DR InterPro; IPR045231; Yip1/4-like.
DR InterPro; IPR006977; Yip1_dom.
DR PANTHER; PTHR21236; PTHR21236; 1.
DR Pfam; PF04893; Yip1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..246
FT /note="Protein YIPF4"
FT /id="PRO_0000242633"
FT TOPO_DOM 1..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9BSR8"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..140
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..197
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..27
FT /note="MQPPGPPPAYAPANGDFTFVSSADAED -> MKKQVDFDIDMEIPGDEPLRP
FT QHLKSRGREIPELKASLDYTVIKFSACRGYILKPCLNKVEKKFQFKDEH (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019457"
SQ SEQUENCE 246 AA; 27283 MW; CE59292A71ED818F CRC64;
MQPPGPPPAY APANGDFTFV SSADAEDLSG SIAAPDVKLN LGVSGDFIKE STATTFLRQR
GYGWLLEVED EDPEDNKPLL EELDIDLKDI YYKIRCVLMP MPSLGFNRQV VRDNPDFWGP
LAVVLFFSMI SLYGQFRVVS WIITIWIFGS LTIFLLARVL GGEVAYGQVL GVIGYSLLPL
IVIAPILLVV GSFEMVSTLI KLFGVFWAAY SAASLLVGEE FKTKKPLLIY PIFLLYIYFL
SLYTGV
