YIPF5_BOVIN
ID YIPF5_BOVIN Reviewed; 257 AA.
AC Q5E9E8; A1L5B9;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein YIPF5;
DE AltName: Full=YIP1 family member 5;
GN Name=YIPF5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and
CC Golgi. In pancreatic beta cells, required to transport proinsulin from
CC endoplasmic reticulum into the Golgi. {ECO:0000250|UniProtKB:Q969M3}.
CC -!- SUBUNIT: Interacts with the COPII coat components Sec23 (SEC23A and/or
CC SEC23B) and Sec24 (SEC24A and/or SEC24B) (By similarity). Interacts
CC with YIF1A (By similarity). May interact with RAB1A (By similarity).
CC Interacts with YIPF3 and YIPF4 (By similarity).
CC {ECO:0000250|UniProtKB:Q969M3}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9EQQ2}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q969M3}. Golgi apparatus, cis-Golgi network
CC membrane {ECO:0000250|UniProtKB:Q969M3}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q969M3}. Cytoplasmic vesicle, COPII-coated
CC vesicle {ECO:0000250|UniProtKB:Q5XID0}. Note=Enriched at the
CC endoplasmic reticulum exit sites (By similarity). Incorporated into
CC COPII-coated vesicles (By similarity). {ECO:0000250|UniProtKB:Q5XID0,
CC ECO:0000250|UniProtKB:Q9EQQ2}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
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DR EMBL; BT020972; AAX08989.1; -; mRNA.
DR EMBL; BT029906; ABM06152.1; -; mRNA.
DR EMBL; BC102241; AAI02242.1; -; mRNA.
DR RefSeq; NP_001029715.1; NM_001034543.1.
DR RefSeq; XP_010805715.1; XM_010807413.2.
DR AlphaFoldDB; Q5E9E8; -.
DR STRING; 9913.ENSBTAP00000016956; -.
DR PaxDb; Q5E9E8; -.
DR PRIDE; Q5E9E8; -.
DR Ensembl; ENSBTAT00000016956; ENSBTAP00000016956; ENSBTAG00000012758.
DR GeneID; 521829; -.
DR KEGG; bta:521829; -.
DR CTD; 81555; -.
DR VEuPathDB; HostDB:ENSBTAG00000012758; -.
DR VGNC; VGNC:37027; YIPF5.
DR eggNOG; KOG3103; Eukaryota.
DR GeneTree; ENSGT00940000153168; -.
DR HOGENOM; CLU_074741_2_0_1; -.
DR InParanoid; Q5E9E8; -.
DR OMA; IGINFDH; -.
DR OrthoDB; 1457080at2759; -.
DR TreeFam; TF313100; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000012758; Expressed in caput epididymis and 105 other tissues.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042175; C:nuclear outer membrane-endoplasmic reticulum membrane network; ISS:AgBase.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0030070; P:insulin processing; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IBA:GO_Central.
DR InterPro; IPR045231; Yip1/4-like.
DR PANTHER; PTHR21236; PTHR21236; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..257
FT /note="Protein YIPF5"
FT /id="PRO_0000234327"
FT TOPO_DOM 1..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q969M3"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..173
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..196
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 75..106
FT /note="Interaction with Sec23"
FT /evidence="ECO:0000250"
SQ SEQUENCE 257 AA; 28016 MW; C9EBB968D6BD3432 CRC64;
MSGFDNLNTD FYQTSYSIDD QSQQSYDYGG SGGPYSKQYA GYDYSHQGRF VPADMMQPQQ
PYTGQIFQPT QTYTPTTPQP FYGNNFEDEP PLLEELGINF DHIWQKTLTV LHPLKVADGS
IMNETDLAGP MVFCLAFGAT LLLAGKIQFG YVYGISAIGC LGMFCLLNLM SMTGVSFGCV
ASVLGYCLLP MILLSSFAVI FSLQGMVGII LTAGIIGWCS FSASKIFISA LAMEGQQLLV
AYPCALLYGV FALISVF
