ID   YIPF5_MACFA             Reviewed;         257 AA.
AC   Q4R5M4;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Protein YIPF5;
DE   AltName: Full=YIP1 family member 5;
GN   Name=YIPF5; ORFNames=QccE-13521;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and
CC       Golgi. In pancreatic beta cells, required to transport proinsulin from
CC       endoplasmic reticulum into the Golgi. {ECO:0000250|UniProtKB:Q969M3}.
CC   -!- SUBUNIT: Interacts with the COPII coat components Sec23 (SEC23A and/or
CC       SEC23B) and Sec24 (SEC24A and/or SEC24B) (By similarity). Interacts
CC       with YIF1A (By similarity). May interact with RAB1A (By similarity).
CC       Interacts with YIPF3 and YIPF4 (By similarity).
CC       {ECO:0000250|UniProtKB:Q969M3}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9EQQ2}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q969M3}. Golgi apparatus, cis-Golgi network
CC       membrane {ECO:0000250|UniProtKB:Q969M3}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q969M3}. Cytoplasmic vesicle, COPII-coated
CC       vesicle {ECO:0000250|UniProtKB:Q5XID0}. Note=Enriched at the
CC       endoplasmic reticulum exit sites (By similarity). Incorporated into
CC       COPII-coated vesicles (By similarity). {ECO:0000250|UniProtKB:Q5XID0,
CC       ECO:0000250|UniProtKB:Q9EQQ2}.
CC   -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
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DR   EMBL; AB169519; BAE01601.1; -; mRNA.
DR   RefSeq; XP_005558175.1; XM_005558118.2.
DR   AlphaFoldDB; Q4R5M4; -.
DR   STRING; 9541.XP_005558174.1; -.
DR   Ensembl; ENSMFAT00000022290; ENSMFAP00000003629; ENSMFAG00000001553.
DR   GeneID; 101866225; -.
DR   KEGG; mcf:101866225; -.
DR   CTD; 81555; -.
DR   VEuPathDB; HostDB:ENSMFAG00000001553; -.
DR   eggNOG; KOG3103; Eukaryota.
DR   GeneTree; ENSGT00940000153168; -.
DR   OMA; IGINFDH; -.
DR   OrthoDB; 1457080at2759; -.
DR   Proteomes; UP000233100; Chromosome 6.
DR   Bgee; ENSMFAG00000001553; Expressed in pituitary gland and 13 other tissues.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:Ensembl.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0030070; P:insulin processing; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR045231; Yip1/4-like.
DR   PANTHER; PTHR21236; PTHR21236; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..257
FT                   /note="Protein YIPF5"
FT                   /id="PRO_0000234329"
FT   TOPO_DOM        1..124
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q969M3"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..173
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        195..196
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          75..106
FT                   /note="Interaction with Sec23"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   257 AA;  27962 MW;  A57788363161042D CRC64;
     MSGFENLNTD FYQTSYSIDD QSQQSYDYGG SGGPYSKQYA GYDYSQQGRF VPPDMMQPQQ
     PYTGQIYQPT QAYTPASPQP FYGNSFEDEP PLLEELGINF DHIWQKTLTV LHPLKVADGS
     IMNETDLAGP MVFCLAFGAT LLLAGKIQFG YVYGISAIGC LGMFCLLNLM SMTGVSFGCV
     ASVLGYCLLP MILLSSFAVI FSLQGMVGII LTAGIIGWCS FSASKIFISA LAMEGQQLLV
     AYPCALLYGV FALISVF