YIPF5_RAT
ID YIPF5_RAT Reviewed; 257 AA.
AC Q5XID0;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Protein YIPF5;
DE AltName: Full=YIP1 family member 5;
DE AltName: Full=YPT-interacting protein 1 A;
GN Name=Yipf5 {ECO:0000312|RGD:1359165}; Synonyms=Yip1a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11489904; DOI=10.1074/jbc.m106189200;
RA Tang B.L., Ong Y.S., Huang B., Wei S., Wong E.T., Qi R., Horstmann H.,
RA Hong W.;
RT "A membrane protein enriched in endoplasmic reticulum exit sites interacts
RT with COPII.";
RL J. Biol. Chem. 276:40008-40017(2001).
CC -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and
CC Golgi. In pancreatic beta cells, required to transport proinsulin from
CC endoplasmic reticulum into the Golgi (By similarity).
CC {ECO:0000250|UniProtKB:Q969M3, ECO:0000269|PubMed:11489904}.
CC -!- SUBUNIT: Interacts with the COPII coat components Sec23 (SEC23A and/or
CC SEC23B) and Sec24 (SEC24A and/or SEC24B) (By similarity). Interacts
CC with YIF1A (By similarity). May interact with RAB1A (By similarity).
CC Interacts with YIPF3 and YIPF4 (By similarity).
CC {ECO:0000250|UniProtKB:Q969M3}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:11489904}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:11489904}. Golgi apparatus, cis-Golgi network
CC membrane {ECO:0000269|PubMed:11489904}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:11489904}. Cytoplasmic vesicle, COPII-coated
CC vesicle {ECO:0000269|PubMed:11489904}. Note=Enriched at the endoplasmic
CC reticulum exit sites. Incorporated into COPII coated vesicles.
CC {ECO:0000269|PubMed:11489904}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
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DR EMBL; BC083754; AAH83754.1; -; mRNA.
DR RefSeq; NP_001014172.3; NM_001014150.3.
DR AlphaFoldDB; Q5XID0; -.
DR STRING; 10116.ENSRNOP00000041654; -.
DR jPOST; Q5XID0; -.
DR PRIDE; Q5XID0; -.
DR Ensembl; ENSRNOT00000020385; ENSRNOP00000020385; ENSRNOG00000014564.
DR GeneID; 361315; -.
DR KEGG; rno:361315; -.
DR UCSC; RGD:1359165; rat.
DR CTD; 81555; -.
DR RGD; 1359165; Yipf5.
DR eggNOG; KOG3103; Eukaryota.
DR GeneTree; ENSGT00940000153168; -.
DR HOGENOM; CLU_074741_2_0_1; -.
DR InParanoid; Q5XID0; -.
DR OMA; IGINFDH; -.
DR PRO; PR:Q5XID0; -.
DR Proteomes; UP000002494; Chromosome 18.
DR Bgee; ENSRNOG00000014564; Expressed in pancreas and 20 other tissues.
DR ExpressionAtlas; Q5XID0; baseline and differential.
DR Genevisible; Q5XID0; RN.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; ISO:RGD.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:RGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042175; C:nuclear outer membrane-endoplasmic reticulum membrane network; ISO:RGD.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0030070; P:insulin processing; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IBA:GO_Central.
DR InterPro; IPR045231; Yip1/4-like.
DR PANTHER; PTHR21236; PTHR21236; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..257
FT /note="Protein YIPF5"
FT /id="PRO_0000234332"
FT TOPO_DOM 1..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q969M3"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..173
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..196
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 75..106
FT /note="Interaction with Sec23"
FT /evidence="ECO:0000250"
SQ SEQUENCE 257 AA; 27903 MW; 70F867980D62DD38 CRC64;
MSGFDNLNSG FYQTSYSIDE QSQQSYDYGG SGGPYSKQYA GCEYSQQGRF VPPDMMQPQQ
TYTGQIYQPT QAYPPPTPQT FYGDSFEEEP PLLEELGINF DHIWQKTLTV LHPLRASDGS
IMNETDLAGP VVFCLAFGAT LLLAGKIQFG YVYGISAIGC LGMFCLLNLM SMTGVSFGCV
ASVLGYCLLP MILLSSFAVV FSLQGMVGIL LTATIIGWCS FSASKIFISA LAMDGQQLLV
AYPCALLYGV FALISVF
