ID   CBIE_SALTY              Reviewed;         201 AA.
AC   P0A2H1; Q05629;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Cobalt-precorrin-7 C(5)-methyltransferase;
DE            EC=2.1.1.289;
DE   AltName: Full=Cobalt-precorrin-6Y C(5)-methyltransferase;
DE            Short=Cobalt-precorrin-6 methyltransferase;
DE            Short=Cobalt-precorrin-6Y methylase;
GN   Name=cbiE; OrderedLocusNames=STM2031;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF N-TERMINUS.
RC   STRAIN=LT2;
RX   PubMed=8501034; DOI=10.1128/jb.175.11.3303-3316.1993;
RA   Roth J.R., Lawrence J.G., Rubenfield M., Kieffer-Higgins S., Church G.M.;
RT   "Characterization of the cobalamin (vitamin B12) biosynthetic genes of
RT   Salmonella typhimurium.";
RL   J. Bacteriol. 175:3303-3316(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-10.
RX   PubMed=1451790; DOI=10.1016/0014-5793(92)80213-z;
RA   Roessner C.A., Warren M.J., Santander P.J., Atshaves B.P., Ozaki S.,
RA   Stolowich N.J., Iida K., Scott A.I.;
RT   "Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis.
RT   Identification of the 11-methyl and 20-methyl transferases of corrin
RT   biosynthesis.";
RL   FEBS Lett. 301:73-78(1992).
RN   [4]
RP   FUNCTION.
RX   PubMed=16198574; DOI=10.1016/j.bmc.2005.08.062;
RA   Santander P.J., Kajiwara Y., Williams H.J., Scott A.I.;
RT   "Structural characterization of novel cobalt corrinoids synthesized by
RT   enzymes of the vitamin B12 anaerobic pathway.";
RL   Bioorg. Med. Chem. 14:724-731(2006).
CC   -!- FUNCTION: Catalyzes the methylation of C-5 in cobalt-precorrin-7 to
CC       form cobalt-precorrin-8. {ECO:0000269|PubMed:16198574}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co-precorrin-7 + S-adenosyl-L-methionine = Co-precorrin-8X +
CC         H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:34591,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:70791, ChEBI:CHEBI:70792; EC=2.1.1.289;
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 8/10.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; L12006; AAA27256.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20935.1; -; Genomic_DNA.
DR   RefSeq; NP_460976.1; NC_003197.2.
DR   RefSeq; WP_000958833.1; NC_003197.2.
DR   AlphaFoldDB; P0A2H1; -.
DR   SMR; P0A2H1; -.
DR   STRING; 99287.STM2031; -.
DR   PaxDb; P0A2H1; -.
DR   EnsemblBacteria; AAL20935; AAL20935; STM2031.
DR   GeneID; 1253552; -.
DR   KEGG; stm:STM2031; -.
DR   PATRIC; fig|99287.12.peg.2153; -.
DR   HOGENOM; CLU_089162_2_0_6; -.
DR   OMA; DPCFSGL; -.
DR   PhylomeDB; P0A2H1; -.
DR   BioCyc; MetaCyc:MON-13225; -.
DR   BioCyc; SENT99287:STM2031-MON; -.
DR   UniPathway; UPA00148; UER00229.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0043777; F:cobalt-precorrin-7 C15-methyltransferase activity; IEA:RHEA.
DR   GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd11644; Precorrin-6Y-MT; 1.
DR   Gene3D; 3.30.950.10; -; 1.
DR   Gene3D; 3.40.1010.10; -; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR012818; CbiE.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF53790; SSF53790; 1.
DR   TIGRFAMs; TIGR02467; CbiE; 1.
PE   1: Evidence at protein level;
KW   Cobalamin biosynthesis; Direct protein sequencing; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..201
FT                   /note="Cobalt-precorrin-7 C(5)-methyltransferase"
FT                   /id="PRO_0000150407"
SQ   SEQUENCE   201 AA;  21778 MW;  24D2F30887703FB1 CRC64;
     MLTVVGMGPA GRHLMTPAAL EAIDHADALA GGKRHLAQFP AFGGERFTLG ADIGALLSWI
     AARRDKGIVV LASGDPLFYG IGTRLVAHFG IEQVRIIPGI SAVQYLCAQA GIDMNDMWLT
     SSHGRCVSFE QLANHRKVAM VTDARCGPRE IARELVARGK GHRLMVIGEN LAMENERIHW
     LPVSAVNADY EMNAVVILDE R