YIPF6_HUMAN
ID YIPF6_HUMAN Reviewed; 236 AA.
AC Q96EC8; B4E1U7; G5E997; Q5JP08;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Protein YIPF6;
DE AltName: Full=YIP1 family member 6;
GN Name=YIPF6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT LEU-202.
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH YIPF1 AND YIPF2.
RX PubMed=28286305; DOI=10.1016/j.yexcr.2017.03.011;
RA Soonthornsit J., Sakai N., Sasaki Y., Watanabe R., Osako S., Nakamura N.;
RT "YIPF1, YIPF2, and YIPF6 are medial-/trans-Golgi and trans-Golgi network-
RT localized Yip domain family proteins, which play a role in the Golgi
RT reassembly and glycan synthesis.";
RL Exp. Cell Res. 353:100-108(2017).
RN [8]
RP SUBCELLULAR LOCATION, AND TOPOLOGY.
RX PubMed=27999994; DOI=10.1007/s00418-016-1527-3;
RA Kranjc T., Dempsey E., Cagney G., Nakamura N., Shields D.C., Simpson J.C.;
RT "Functional characterisation of the YIPF protein family in mammalian
RT cells.";
RL Histochem. Cell Biol. 147:439-451(2017).
CC -!- FUNCTION: May be required for stable YIPF1 and YIPF2 protein
CC expression. {ECO:0000269|PubMed:28286305}.
CC -!- SUBUNIT: Predominantly interacts with YIPF1 or YIPF2, but may also form
CC a ternary complex with YIPF1 and YIPF2. This interaction may stabilize
CC YIPF1 and YIPF2. {ECO:0000269|PubMed:28286305}.
CC -!- INTERACTION:
CC Q96EC8; Q9BQE5: APOL2; NbExp=3; IntAct=EBI-751210, EBI-4290634;
CC Q96EC8; P41181: AQP2; NbExp=3; IntAct=EBI-751210, EBI-12701138;
CC Q96EC8; Q13520: AQP6; NbExp=3; IntAct=EBI-751210, EBI-13059134;
CC Q96EC8; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-751210, EBI-11343438;
CC Q96EC8; O15342: ATP6V0E1; NbExp=3; IntAct=EBI-751210, EBI-12935759;
CC Q96EC8; P11912: CD79A; NbExp=3; IntAct=EBI-751210, EBI-7797864;
CC Q96EC8; Q99675: CGRRF1; NbExp=3; IntAct=EBI-751210, EBI-2130213;
CC Q96EC8; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-751210, EBI-1045797;
CC Q96EC8; P34972: CNR2; NbExp=3; IntAct=EBI-751210, EBI-2835940;
CC Q96EC8; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-751210, EBI-18013275;
CC Q96EC8; Q9BUF7-2: CRB3; NbExp=3; IntAct=EBI-751210, EBI-17233035;
CC Q96EC8; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-751210, EBI-6942903;
CC Q96EC8; Q68CJ9: CREB3L3; NbExp=3; IntAct=EBI-751210, EBI-852194;
CC Q96EC8; Q5JRM2: CXorf66; NbExp=3; IntAct=EBI-751210, EBI-12823659;
CC Q96EC8; Q15125: EBP; NbExp=3; IntAct=EBI-751210, EBI-3915253;
CC Q96EC8; P52803: EFNA5; NbExp=3; IntAct=EBI-751210, EBI-1753674;
CC Q96EC8; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-751210, EBI-18535450;
CC Q96EC8; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-751210, EBI-781551;
CC Q96EC8; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-751210, EBI-18304435;
CC Q96EC8; O15552: FFAR2; NbExp=3; IntAct=EBI-751210, EBI-2833872;
CC Q96EC8; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-751210, EBI-3918971;
CC Q96EC8; P36382: GJA5; NbExp=3; IntAct=EBI-751210, EBI-750433;
CC Q96EC8; P48165: GJA8; NbExp=3; IntAct=EBI-751210, EBI-17458373;
CC Q96EC8; P08034: GJB1; NbExp=3; IntAct=EBI-751210, EBI-17565645;
CC Q96EC8; Q96P66: GPR101; NbExp=3; IntAct=EBI-751210, EBI-17935713;
CC Q96EC8; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-751210, EBI-13345167;
CC Q96EC8; O15529: GPR42; NbExp=3; IntAct=EBI-751210, EBI-18076404;
CC Q96EC8; Q8TED1: GPX8; NbExp=3; IntAct=EBI-751210, EBI-11721746;
CC Q96EC8; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-751210, EBI-1052304;
CC Q96EC8; Q13651: IL10RA; NbExp=3; IntAct=EBI-751210, EBI-1031656;
CC Q96EC8; Q01638-2: IL1RL1; NbExp=3; IntAct=EBI-751210, EBI-12838366;
CC Q96EC8; Q6UWB1: IL27RA; NbExp=3; IntAct=EBI-751210, EBI-19045531;
CC Q96EC8; Q9P055-4: JKAMP; NbExp=3; IntAct=EBI-751210, EBI-13310605;
CC Q96EC8; P48051: KCNJ6; NbExp=3; IntAct=EBI-751210, EBI-12017638;
CC Q96EC8; O95279: KCNK5; NbExp=3; IntAct=EBI-751210, EBI-3934936;
CC Q96EC8; Q8N386: LRRC25; NbExp=3; IntAct=EBI-751210, EBI-11304917;
CC Q96EC8; Q96PB8: LRRC3B; NbExp=3; IntAct=EBI-751210, EBI-17775622;
CC Q96EC8; Q9HCJ2: LRRC4C; NbExp=3; IntAct=EBI-751210, EBI-3925442;
CC Q96EC8; O95867: LY6G6C; NbExp=3; IntAct=EBI-751210, EBI-9088345;
CC Q96EC8; Q9Y5Y7: LYVE1; NbExp=3; IntAct=EBI-751210, EBI-10329546;
CC Q96EC8; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-751210, EBI-373355;
CC Q96EC8; Q6N075: MFSD5; NbExp=3; IntAct=EBI-751210, EBI-3920969;
CC Q96EC8; Q15546: MMD; NbExp=3; IntAct=EBI-751210, EBI-17873222;
CC Q96EC8; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-751210, EBI-12806656;
CC Q96EC8; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-751210, EBI-3923617;
CC Q96EC8; Q9Y375: NDUFAF1; NbExp=3; IntAct=EBI-751210, EBI-741874;
CC Q96EC8; Q2M2E3: ODF4; NbExp=3; IntAct=EBI-751210, EBI-12382569;
CC Q96EC8; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-751210, EBI-716063;
CC Q96EC8; Q5VY80: RAET1L; NbExp=3; IntAct=EBI-751210, EBI-16364752;
CC Q96EC8; Q86VR2: RETREG3; NbExp=5; IntAct=EBI-751210, EBI-10192441;
CC Q96EC8; Q9UBD6: RHCG; NbExp=3; IntAct=EBI-751210, EBI-15853497;
CC Q96EC8; Q96GF1: RNF185; NbExp=3; IntAct=EBI-751210, EBI-2340249;
CC Q96EC8; Q14973: SLC10A1; NbExp=3; IntAct=EBI-751210, EBI-3923031;
CC Q96EC8; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-751210, EBI-18159983;
CC Q96EC8; Q9Y666-2: SLC12A7; NbExp=3; IntAct=EBI-751210, EBI-12854384;
CC Q96EC8; Q8NDX2-2: SLC17A8; NbExp=3; IntAct=EBI-751210, EBI-17249797;
CC Q96EC8; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-751210, EBI-17595455;
CC Q96EC8; O14863: SLC30A4; NbExp=3; IntAct=EBI-751210, EBI-13918058;
CC Q96EC8; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-751210, EBI-10262251;
CC Q96EC8; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-751210, EBI-17295964;
CC Q96EC8; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-751210, EBI-10314552;
CC Q96EC8; Q9NY26: SLC39A1; NbExp=3; IntAct=EBI-751210, EBI-726491;
CC Q96EC8; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-751210, EBI-12898013;
CC Q96EC8; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-751210, EBI-5235586;
CC Q96EC8; Q9UHI5: SLC7A8; NbExp=3; IntAct=EBI-751210, EBI-13292283;
CC Q96EC8; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-751210, EBI-17280858;
CC Q96EC8; P27105: STOM; NbExp=3; IntAct=EBI-751210, EBI-1211440;
CC Q96EC8; P57738: TCTA; NbExp=3; IntAct=EBI-751210, EBI-6447595;
CC Q96EC8; Q8WY91: THAP4; NbExp=3; IntAct=EBI-751210, EBI-726691;
CC Q96EC8; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-751210, EBI-2821497;
CC Q96EC8; P17152: TMEM11; NbExp=3; IntAct=EBI-751210, EBI-723946;
CC Q96EC8; Q8N3G9: TMEM130; NbExp=3; IntAct=EBI-751210, EBI-19763514;
CC Q96EC8; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-751210, EBI-8638294;
CC Q96EC8; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-751210, EBI-10982110;
CC Q96EC8; Q6P5X7-2: TMEM71; NbExp=3; IntAct=EBI-751210, EBI-12886878;
CC Q96EC8; Q9Y320: TMX2; NbExp=3; IntAct=EBI-751210, EBI-6447886;
CC Q96EC8; P34981: TRHR; NbExp=3; IntAct=EBI-751210, EBI-18055230;
CC Q96EC8; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-751210, EBI-11988865;
CC Q96EC8; Q9NYZ1: TVP23B; NbExp=6; IntAct=EBI-751210, EBI-11343401;
CC Q96EC8; Q9BZM5: ULBP2; NbExp=3; IntAct=EBI-751210, EBI-3919993;
CC Q96EC8; Q9Y548: YIPF1; NbExp=8; IntAct=EBI-751210, EBI-7850136;
CC Q96EC8; Q9BWQ6: YIPF2; NbExp=9; IntAct=EBI-751210, EBI-751204;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein
CC {ECO:0000305}. Note=Evenly distributed between cis- and trans-Golgi
CC apparatus (PubMed:27999994). Mainly localizes within medial-/trans-
CC Golgi and trans-Golgi network (TGN), while less so within cis-Golgi
CC (PubMed:28286305). {ECO:0000269|PubMed:27999994,
CC ECO:0000269|PubMed:28286305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96EC8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96EC8-2; Sequence=VSP_047121;
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
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DR EMBL; AK303992; BAG64909.1; -; mRNA.
DR EMBL; AL928603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL672138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471132; EAX05376.1; -; Genomic_DNA.
DR EMBL; BC012469; AAH12469.1; -; mRNA.
DR CCDS; CCDS14389.1; -. [Q96EC8-1]
DR CCDS; CCDS56604.1; -. [Q96EC8-2]
DR RefSeq; NP_001182143.1; NM_001195214.1. [Q96EC8-2]
DR RefSeq; NP_776195.2; NM_173834.3. [Q96EC8-1]
DR AlphaFoldDB; Q96EC8; -.
DR BioGRID; 130382; 114.
DR IntAct; Q96EC8; 94.
DR MINT; Q96EC8; -.
DR STRING; 9606.ENSP00000417573; -.
DR GlyGen; Q96EC8; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96EC8; -.
DR PhosphoSitePlus; Q96EC8; -.
DR BioMuta; YIPF6; -.
DR DMDM; 109896316; -.
DR EPD; Q96EC8; -.
DR jPOST; Q96EC8; -.
DR MassIVE; Q96EC8; -.
DR MaxQB; Q96EC8; -.
DR PaxDb; Q96EC8; -.
DR PeptideAtlas; Q96EC8; -.
DR PRIDE; Q96EC8; -.
DR ProteomicsDB; 33874; -.
DR ProteomicsDB; 76395; -. [Q96EC8-1]
DR Antibodypedia; 554; 55 antibodies from 15 providers.
DR DNASU; 286451; -.
DR Ensembl; ENST00000374622.3; ENSP00000363751.2; ENSG00000181704.12. [Q96EC8-2]
DR Ensembl; ENST00000462683.6; ENSP00000417573.1; ENSG00000181704.12. [Q96EC8-1]
DR GeneID; 286451; -.
DR KEGG; hsa:286451; -.
DR MANE-Select; ENST00000462683.6; ENSP00000417573.1; NM_173834.4; NP_776195.2.
DR UCSC; uc004dwz.4; human. [Q96EC8-1]
DR CTD; 286451; -.
DR DisGeNET; 286451; -.
DR GeneCards; YIPF6; -.
DR HGNC; HGNC:28304; YIPF6.
DR HPA; ENSG00000181704; Low tissue specificity.
DR MIM; 300996; gene.
DR neXtProt; NX_Q96EC8; -.
DR OpenTargets; ENSG00000181704; -.
DR PharmGKB; PA142670549; -.
DR VEuPathDB; HostDB:ENSG00000181704; -.
DR eggNOG; KOG2946; Eukaryota.
DR GeneTree; ENSGT00940000153168; -.
DR HOGENOM; CLU_059592_3_0_1; -.
DR InParanoid; Q96EC8; -.
DR OMA; CVMPLTV; -.
DR OrthoDB; 1287193at2759; -.
DR PhylomeDB; Q96EC8; -.
DR TreeFam; TF314563; -.
DR PathwayCommons; Q96EC8; -.
DR Reactome; R-HSA-432722; Golgi Associated Vesicle Biogenesis.
DR SignaLink; Q96EC8; -.
DR BioGRID-ORCS; 286451; 18 hits in 706 CRISPR screens.
DR ChiTaRS; YIPF6; human.
DR GeneWiki; YIPF6; -.
DR GenomeRNAi; 286451; -.
DR Pharos; Q96EC8; Tdark.
DR PRO; PR:Q96EC8; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q96EC8; protein.
DR Bgee; ENSG00000181704; Expressed in secondary oocyte and 217 other tissues.
DR ExpressionAtlas; Q96EC8; baseline and differential.
DR Genevisible; Q96EC8; HS.
DR GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
DR GO; GO:0005797; C:Golgi medial cisterna; IDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000138; C:Golgi trans cisterna; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0060576; P:intestinal epithelial cell development; IEA:Ensembl.
DR InterPro; IPR045231; Yip1/4-like.
DR InterPro; IPR006977; Yip1_dom.
DR PANTHER; PTHR21236; PTHR21236; 1.
DR Pfam; PF04893; Yip1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Golgi apparatus; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22223895,
FT ECO:0007744|PubMed:22814378"
FT CHAIN 2..236
FT /note="Protein YIPF6"
FT /id="PRO_0000242668"
FT TOPO_DOM 2..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:27999994"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..115
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..184
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..212
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..236
FT /note="Lumenal"
FT /evidence="ECO:0000305|PubMed:27999994"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:22223895,
FT ECO:0007744|PubMed:22814378"
FT MOD_RES 7
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4QQU5"
FT VAR_SEQ 20..62
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047121"
FT VARIANT 202
FT /note="F -> L (in dbSNP:rs17850921)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026855"
FT CONFLICT 95
FT /note="L -> S (in Ref. 1; BAG64909)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 236 AA; 26256 MW; 2BAF422A0EF286AD CRC64;
MAEAEESPGD PGTASPRPLF AGLSDISISQ DIPVEGEITI PMRSRIREFD SSTLNESVRN
TIMRDLKAVG KKFMHVLYPR KSNTLLRDWD LWGPLILCVT LALMLQRDSA DSEKDGGPQF
AEVFVIVWFG AVTITLNSKL LGGNISFFQS LCVLGYCILP LTVAMLICRL VLLADPGPVN
FMVRLFVVIV MFAWSIVAST AFLADSQPPN RRALAVYPVF LFYFVISWMI LTFTPQ
