YIPF6_MOUSE
ID YIPF6_MOUSE Reviewed; 236 AA.
AC Q8BR70; Q8C531;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Protein YIPF6;
DE AltName: Full=YIP1 family member 6;
GN Name=Yipf6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Eye, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be required for stable YIPF1 and YIPF2 protein
CC expression. {ECO:0000250|UniProtKB:Q96EC8}.
CC -!- SUBUNIT: Predominantly interacts with YIPF1 or YIPF2, but may also form
CC a ternary complex with YIPF1 and YIPF2. This interaction may stabilize
CC YIPF1 and YIPF2. {ECO:0000250|UniProtKB:Q96EC8}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q96EC8}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q96EC8}. Note=Evenly distributed between
CC cis- and trans-Golgi apparatus. Mainly localizes within medial-/trans-
CC Golgi and trans-Golgi network (TGN), while less so within cis-Golgi.
CC {ECO:0000250|UniProtKB:Q96EC8}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK045453; BAC32377.1; -; mRNA.
DR EMBL; AK079683; BAC37722.1; -; mRNA.
DR EMBL; AK143152; BAE25283.1; -; mRNA.
DR EMBL; BC048712; AAH48712.1; -; mRNA.
DR CCDS; CCDS30296.1; -.
DR RefSeq; NP_997516.1; NM_207633.2.
DR RefSeq; XP_006528401.2; XM_006528338.3.
DR RefSeq; XP_006528402.2; XM_006528339.3.
DR AlphaFoldDB; Q8BR70; -.
DR BioGRID; 219028; 1.
DR STRING; 10090.ENSMUSP00000056039; -.
DR iPTMnet; Q8BR70; -.
DR PhosphoSitePlus; Q8BR70; -.
DR jPOST; Q8BR70; -.
DR MaxQB; Q8BR70; -.
DR PaxDb; Q8BR70; -.
DR PRIDE; Q8BR70; -.
DR ProteomicsDB; 299607; -.
DR Antibodypedia; 554; 55 antibodies from 15 providers.
DR Ensembl; ENSMUST00000054697; ENSMUSP00000056039; ENSMUSG00000047694.
DR Ensembl; ENSMUST00000113811; ENSMUSP00000109442; ENSMUSG00000047694.
DR GeneID; 77929; -.
DR KEGG; mmu:77929; -.
DR UCSC; uc009tvd.1; mouse.
DR CTD; 286451; -.
DR MGI; MGI:1925179; Yipf6.
DR VEuPathDB; HostDB:ENSMUSG00000047694; -.
DR eggNOG; KOG2946; Eukaryota.
DR GeneTree; ENSGT00940000153168; -.
DR HOGENOM; CLU_059592_3_0_1; -.
DR InParanoid; Q8BR70; -.
DR OMA; CVMPLTV; -.
DR OrthoDB; 1287193at2759; -.
DR PhylomeDB; Q8BR70; -.
DR TreeFam; TF314563; -.
DR Reactome; R-MMU-432722; Golgi Associated Vesicle Biogenesis.
DR BioGRID-ORCS; 77929; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Yipf6; mouse.
DR PRO; PR:Q8BR70; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8BR70; protein.
DR Bgee; ENSMUSG00000047694; Expressed in secondary oocyte and 220 other tissues.
DR ExpressionAtlas; Q8BR70; baseline and differential.
DR Genevisible; Q8BR70; MM.
DR GO; GO:0005801; C:cis-Golgi network; IDA:MGI.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IDA:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005797; C:Golgi medial cisterna; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000138; C:Golgi trans cisterna; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; IDA:MGI.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0060576; P:intestinal epithelial cell development; IMP:MGI.
DR InterPro; IPR045231; Yip1/4-like.
DR InterPro; IPR006977; Yip1_dom.
DR PANTHER; PTHR21236; PTHR21236; 1.
DR Pfam; PF04893; Yip1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q96EC8"
FT CHAIN 2..236
FT /note="Protein YIPF6"
FT /id="PRO_0000242669"
FT TOPO_DOM 2..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96EC8"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..116
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..185
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..236
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96EC8"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q96EC8"
FT MOD_RES 7
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4QQU5"
SQ SEQUENCE 236 AA; 26088 MW; FFA5B7FF9F2D555A CRC64;
MAEAEDSPGE QEAAASKPLF AGLSDVSISQ DIPIEGEITI PSRARAQEHD SSTLNESIRR
TIMRDLKAVG RKFMHVLYPR KSNALLRDWD LWGPLILCVT LALMLQKSSI DGKNDGGGPE
FAEVFVIIWF GAVTITLNSK LLGGNISFFQ SLCVLGYCIL PLNIAMLICR LLLLAGQGPI
NFMIRLFVVL LMFAWSVVAS TAFLADSQPP NRKALAVYPV FLFYFVISWM ILTFTP
